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Oncogenic Viral Protein Interactions with p53 Family Proteins

Klin Onkol 2019; 32(Suppl 3): 72-77. DOI: 10.14735/amko20193S72.
Keywords: viry – virové proteiny – p53 – p63 – p73 – tumorigeneze
Authors: Brychtová Veronika, Hrabal Václav, Vojtěšek Bořivoj

Cooperation of Genomic, Transcriptomics and Proteomic Methods in the Detection of Mutated Proteins

Klin Onkol 2019; 32(Suppl 3): 78-85. DOI: 10.14735/amko20193S78.
Keywords: genomics – transcriptomics – proteomics – bioinformatics – software development
Authors: Zavadil Kokáš Filip, Faktor Jakub, Vojtěšek Bořivoj

Recommendations for Preventive Care for Women with Rare Genetic Cause of Breast and Ovarian Cancer

Klin Onkol 2019; 32(Suppl 2): 6-13. DOI: 10.14735/amko2019S6.
Keywords: genes – BRCA1 – BRCA2 – genetic testing – prophylactic mastectomy – salpingo-oophorectomy – high-throughput nucleotide sequencing
Authors: Foretová Lenka, Navrátilová Marie, Svoboda Marek, Vašíčková Petra, Sťahlová Hrabincová Eva, Házová Jana, Kleiblová Petra, Kleibl Zdeněk, Macháčková Eva, Palácová Markéta, Petráková Katarína

Risks of Solid Tumors in Heterozygous Carriers of Recessive Syndromes

Klin Onkol 2019; 32(Suppl 2): 14-23. DOI: 10.14735/amko2019S14.
Keywords: hereditary cancer syndromes – autozomal recessive inheritance – heterozygote – mutation – risk of cancer – predictive testing
Authors: Koudová Monika, Puchmajerová Alena

DICER1 Syndrome

Klin Onkol 2019; 32(Suppl 2): 23-27. DOI: 10.14735/amko2019S23.
Keywords: genetic testing – hereditary cancer syndromes – DICER1 – pleuropulmonary blastoma – cystic nephroma
Authors: Hořínová Věra, Drábová Klára, Nosková Hana, Bajčiová Viera, Šoukalová Jana, Černá Leona, Hůrková Věra, Slabý Ondřej, Štěrba Jaroslav

Breast Cancer in BRCA1/2 Mutation Carriers – Do We Treat It Differently? Focus on Systemic Therapy for BRCA1/2 Associated Breast Cancer

Klin Onkol 2019; 32(Suppl 2): 24-30. DOI: 10.14735/amko2019S24.
Keywords: breast cancer – BRCA1/2 mutation – genomic tests – platinum salts – PARP inhibitors
Authors: Palácová Markéta

Effectiveness of Neoadjuvant Therapy with Platinum-Based Agents for Patients with BRCA1 and BRCA2 Germline Mutations – A Retrospective Analysis of Breast Cancer Patients Treated at MMCI Brno

Klin Onkol 2019; 32(Suppl 2): 31-35. DOI: 10.14735/amko2019S31.
Keywords: breast cancer – genes, BRCA1 – genes, BRCA2 – neoadjuvant therapy – cisplatin – carboplatin – pathologic complete response
Authors: Holánek Miloš, Bílek Ondřej, Nenutil Rudolf, Kazda Tomáš, Selingerová Iveta, Zvaríková Mária, Palácová Markéta, Vyzula Rostislav, Petráková Katarína

Germline CHEK2 Gene Mutations in Hereditary Breast Cancer Predisposition – Mutation Types and their Biological and Clinical Relevance

Klin Onkol 2019; 32(Suppl 2): 36-50. DOI: 10.14735/amko2019S36.
Keywords: breast cancer – CHEK2 – hereditary mutations – variants of unknown significance – functional analysis
Authors: Kleiblová Petra, Stolařová Lenka, Křížová Kateřina, Lhota Filip, Hojný Jan, Zemánková Petra, Havránek Ondřej, Vočka Michal, Černá Marta, Lhotová Klára, Borecká Marianna, Janatová Markéta, Soukupová Jana, Ševčík Jan, Zimovjanová Martina, Kotlas Jaroslav, Panczak Aleš, Veselá Kamila, Červenková Jana, Schneiderová Michaela, Burócziová Monika, Burdová Kamila, Stránecký Viktor, Foretová Lenka, Macháčková Eva, Tavandzis Spiros, Kmoch Stanislav, Macůrek Libor, Kleibl Zdeněk

Twenty Years of BRCA1 and BRCA2 Molecular Analysis at MMCI – Current Developments for the Classification of Variants

Klin Onkol 2019; 32(Suppl 2): 51-71. DOI: 10.14735/amko2019S51.
Keywords: breast cancer – ovarian cancer – BRCA1 gene – BRCA2 gene – germline mutation
Authors: Macháčková Eva, Claes Kathleen, Miková Miroslava, Házová Jana, Sťahlová Hrabincová Eva, Vašíčková Petra, Trbušek Martin, Navrátilová Marie, Svoboda Marek, Foretová Lenka

Contribution of Massive Parallel Sequencing to Diagnosis of Hereditary Ovarian Cancer in the Czech Republic

Klin Onkol 2019; 32(Suppl 2): 72-78. DOI: 10.14735/amko2019S72.
Keywords: ovarian neoplasms – cancer genes – mutation – massively-parallel sequencing – next generation sequencing – gene panel
Authors: Soukupová Jana, Lhotová Klára, Zemánková Petra, Vočka Michal, Janatová Markéta, Stolařová Lenka, Borecká Marianna, Kleiblová Petra, Macháčková Eva, Foretová Lenka, Koudová Monika, Lhota Filip, Tavandzis Spiros, Zikán Michal, Stránecký Viktor, Veselá Kamila, Panczak Aleš, Kotlas Jaroslav, Kleibl Zdeněk

Genetic Causes of Rare Pediatric Ovarian Tumors

Klin Onkol 2019; 32(Suppl 2): 79-91. DOI: 10.14735/amko2019S79.
Keywords: ovarian neoplasms – child – adolescent – hereditary cancer syndromes
Authors: Plevová Pavlína, Geržová Hedvika

Gastrointestinal Polyposes and Lynch Syndrome – a Pathologist’s Perspective

Klin Onkol 2019; 32(Suppl 2): 92-96. DOI: 10.14735/amko2019S92.
Keywords: colorectal carcinoma – Lynch syndrome – gastrointestinal polyposes
Authors: Pokorová Šárka, Fabián Pavel

An Update on Inherited Colon Cancer and Gastrointestinal Polyposis

Klin Onkol 2019; 32(Suppl 2): 97-108. DOI: 10.14735/amko2019S97.
Keywords: colonic polyps – colorectal neoplasms – stomach – polyps – genes – secondary prevention
Authors: Plevová Pavlína

GAPPS – Gastric Adenocarcinoma and Proximal Polyposis of the Stomach Syndrome in 8 Families Tested at Masaryk Memorial Cancer Institute – Prevention and Prophylactic Gastrectomies

Klin Onkol 2019; 32(Suppl 2): 109-117. DOI: 10.14735/amko2019S109.
Keywords: polyposis – gastric – hereditary – gastric cancer – gastrectomy
Authors: Foretová Lenka, Navrátilová Marie, Svoboda Marek, Grell Peter, Němec Libor, Sirotek Lukáš, Obermannová Radka, Novotný Ivo, Šachlová Milana, Fabián Pavel, Kroupa Radek, Vašíčková Petra, Házová Jana, Sťahlová Hrabincová Eva, Macháčková Eva

BAP1 Syndrome – Predisposition to Malignant Mesothelioma, Skin and Uveal Melanoma, Renal and Other Cancers

Klin Onkol 2019; 32(Suppl 2): 118-122. DOI: 10.14735/amko2019S118.
Keywords: genes – melanoma – mesothelioma – kidney neoplasms – genetic testing
Authors: Foretová Lenka, Navrátilová Marie, Svoboda Marek, Házová Jana, Vašíčková Petra, Sťahlová Hrabincová Eva, Fabián Pavel, Schneiderová Monika, Macháčková Eva