E-mail: pospisilova.sarka@fnbrno.cz
Sekce ČOS: Sekce preventivní onkologie
Odborné práce publikované na Linkos.cz
Přehled odborných textů publikovaných autorem na portálu Linkos.cz. Jsou zde uvedeny knihy a brožury, články v Klinické onkologii, tuzemská abstrakta z databáze abstrakt a další texty. Rejstřík není v žádném případě úplným autorským rejstříkem, protože jsou zde uvedeny pouze texty zveřejněné na portálu Linkos.cz.
Publikované knihy
Publikovaná abstrakta
- 13Q DELETION IS PREDOMINANT CYTOGENETIC ABERRATION NEWLY AQUIRED DURING CHRONIC LYMPHOCYTIC LEUKEMIA COURSE IRRESPECTIVE OF DISEASE ACTIVITY AND TREATMENT STATUS
- A Complementary Role of High Throughput Sequencing and Multiparameter Cytometry for Minimal Residual Disease (MRD) Detection in Chronic Lymphocytic Leukemia (CLL):an European Research Initiative (ERIC) Study
- A MULTICENTER, PHASE IV OBSERVATIONAL SAFETY STUDY OF OFATUMUMAB IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL): A EUROPEAN RESEARCH INITIATIVE ON CLL (ERIC) STUDY
- A Multicenter, Phase IV Observational Study Of Ofatumumab In Chronic Lymphocytic Leukemia (CLL): A European Research Initiative On CLL (ERIC) Study
- A Reappraisal of the Biological and Clinical Implications of Chromosomal Translocations in Chronic Lymphocytic Leukemia
- A Systematic Search Into The Role Of IGHV Gene Replacement In Shaping The Immunoglobulin Repertoire Of Chronic Lymphocytic Leukemia
- ADDITIONAL TRISOMIES AMONGST PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA CARRYING TRISOMY 12: THE PARTNER CHROMOSOME MAKES A DIFFERENCE
- ANALYSIS OF MERKEL CELL POLYOMAVIRUS PROGNOSTIC SIGNIFICANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA
- ANALYSIS OF POTENTIALLY BICLONAL CLL PATIENTS WITH TWO OR THREE PRODUCTIVE IGH REARRANGEMENTS
- Analýza genové exprese u folikulárního lymfomu pomocí oligonukleotidových microarrays
- ASSESSMENT OF P53 FUNCTIONALITY IN CHRONIC LYMPHOCYTIC LEUKEMIA BY DIFFERENT ASSAYS; AN ERIC-WIDE APPROACH
- Assessment of p53 Functionality in Chronic Lymphocytic Leukemia by Different Assays; An Eric-Wide Approach
- ATM INACTIVATION DISTURBS ATM-P53 PATHWAY IN RESPONSE TO DNA DAMAGE INDUCED BY DOXORUBICIN BUT NOT FLUDARABINE IN CLL CELLS
- ATM Mutations in Major Stereotyped CLL Subsets: Enrichment in Subset #2 is Associated with Unfavourable Outcome
- B CELL RECEPTOR STEREOTYPY MAKES A CLINICAL DIFFERENCE IN CLL: REVELATIONS FROM A MULTI-INSTITUTIONAL SERIES OF 4615 CASES
- BIOLOGICAL AND CLINICAL RELEVANCE OF MIRNAS INDUCED IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) CELLS DURING ADMINISTRATION OF THERAPY IN VIVO AND IN VITRO
- Clinical Impact of Stereotyped Antigen Receptors in Chronic Lymphocytic Leukemia
- CLL-SPECIFIC RESEQUENCING MICROARRAY AS A TOOL FOR CLL RESEARCH AND DIAGNOSTICS
- Clonal Evolution and Therapy Related Selection Of TP53 Mutations In Chronic Lymphocytic Leukemia Patients
- Clonal Evolution of Malignant Populations In Potentially Biclonal Chronic Lymphocytic Leukemia Patients
- Clustering Adult ACUTE Lymphoblastic Leukemia (ALL) Philadelphia Negative (Ph-) By Whole Exome Sequencing (WES) Analysis
- DEEP SEQUENCING IDENTIFIES TP53 MUTATIONS BEFORE THEIR CLONAL SELECTION BY THERAPY IN CHRONIC LYMPHOCYTIC LEUKEMIA
- Defects of ATM Gene Involving Mutation Lead to Complete Elimination of ATM Function in Chronic Lymphocytic Leukemia
- DEFINITION AND VALIDATION OF NOVEL PROGNOSTIC MARKERS IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA
- Detail Characterization of 22q11 Deletion and Mir-650 Role in CLL Patients
- DETAILED MUTATIONAL ANALYSIS OF TP53 GENE REVEALS HIGH INCIDENCE OF ADDITIONAL MINOR PROPORTION MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
- DETECTION OF MINIMAL RESIDUAL DISEASE IN PATIENT WITH CHRONIC LYMPHOCYTIC LEUKEMIA USING BOTH FOUR-COLOR AND EIGHT-COLOR FLOW CYTOMETRY AND QUANTITATIVE REAL TIME PCR APPROACH
- Differential Distribution Of Recurrent Gene Mutations In Subsets Of Chronic Lymphocytic Leukemia Patients With Stereotyped B-Cell Receptors: Results From A Multicenter Project Of The European Research Initiative On CLL In A Series Of 2482 Cases
- DISSECTING RESISTANCE MECHANISMS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING WHOLE-EXOME SEQUENCING: IMPACT OF RECURRENT RPS15 MUTATIONS ON P53 DYSREGULATION
- DISTINCT FREQUENCY AND PROFILES OF TP53 GENE MUTATIONS IN CLL SUBGROUPS WITH DISTINCT ANTIGEN RECEPTORS: EVIDENCE FOR ANTIGEN-DRIVEN SELECTION OF GENOMIC ABERRATIONS
- DNA čipy (microarrays) a jejich využití v onkologické diagnostice
- EGR2 Mutations in Chronic Lymphocytic Leukemia: A New Bad Player
- EVALUATION OF TP53 MUTATIONS IN CHRONIC LYMPHOCYTIC LEUKEMIA USING RESEQUENCING MICROARRAY PLATFORMS
- FOCUSED MICROARRAY FOR LYMPHOMA DIAGNOSTICS
- Gene-Expression Profile of Steroid-Refractory Acute Graft-Versus-Host Disease
- Gene-Expression Profiling of Graft-Versus-Host Disease by Oligonucleotide Microarrays
- GENOMIC COPY NUMBER ALTERATIONS IN HIGH-RISK CLL PATIENTS HARBORING TP53 DEFECTS: INSIGHTS FROM CONSECUTIVE INVESTIGATIONS
- High Expression of Activation-Induced Cytidine Deaminase and in Vivo Class Switch Recombination in Mantle Cell Lymphoma: Further Support for Antigen Involvement in Lymphomagenesis
- High Expression of LAG3, LPL and ZAP-70 Genes in B-CLL Strongly Correlates with Unmutated IgVH and Early Therapy Requirement
- HIGH LEVEL OF COBLL1, A NOVEL ROR1 BINDING PARTNER, IDENTIFIES CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS WITH MUTATED IGHV
- High-Throughput Profiling of the T-Cell Receptor Gene Repertoire Supports Antigen Drive in the Pathogenesis of Chronic Idiopathic Neutropenia
- High-Throughput T-Cell Receptor Gene Repertoire Profiling in Chronic Lymphocytic Leukemia Reveals a Molecular Signature of Antigen Selection
- HIGH-THROUGHPUT T-CELL RECEPTOR GENE REPERTOIRE PROFILING IN CHRONIC LYMPHOCYTIC LEUKEMIA SUBSET #4: FURTHER EVIDENCE OF ANTIGENIC STIMULATION
- HIGHER-ORDER IMMUNOGLOBULIN SEQUENCE RELATIONS FOR MAJOR SUBSETS OF CHRONIC LYMPHOCYTIC LEUKEMIA: UNIQUENESS VERSUS EQUIVALENCE
- Human Embryonic Stem Cells: Stable or Vulnerable?
- CHARACTERIZATION OF 22Q11 DELETION IN CLL PATIENTS
- CHARACTERIZATION OF P53 AND ATM ABNORMALITIES IN B-CLL PATIENTS
- Charting Unique Signatures of Somatic Hypermutation Amongst Chronic Lymphocytic Leukemia Patients Expressing IGHV4-34 Clonotypic B Cell Receptors
- Chimerism Status as a Possible Marker of Incipient Disease Relapse in Patients with AML.
- CHLORAMBUCIL (CHL) AND FLUDARABINE (F) AS A NEW PRE-TRANSPLANT CONDITIONING FOR PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA (CLL): RESULTS OF IN VITRO AND IN VIVO EXPERIMENTS
- Chronic Lymphocytic Leukemia with Stereotyped IGHV4-59/IGKV3-20 B Cell Receptors: Another Manifestation of Hepatitis C Virus-Associated B Cell Lymphoproliferation?
- IMMUNOGLOBULIN HEAVY VARIABLE GENES AND ALLELES: NEW ENTITIES, NEW NAMES AND IMPLICATIONS FOR RESEARCH AND PROGNOSTICATION IN CLL
- INCORPORATION OF NEXT-GENERATION SEQUENCING INTO ATM GENE ANALYSIS IN PATIENTS WITH CLL AND MCL
- Inhibition of Chk1 Kinase Sensitizes Leukemia and Lymphoma Cell Lines with TP53 Mutations to Chemotherapy
- Interactions with the Microenvironment Protect Lymphoma B-Cells From Rituximab Induced Apoptosis and Could Represent a Therapeutic Target
- Microenvironmental Interactions up-Regulate CD20 Expression in CLL B Cells through the CXCR4/SDF-1 Axis: Implications for CD20-Targeting Antibodies and the Use of BCR-Inhibitors in Combination
- Microrna-34a As a Marker for Fludarabine Resistance and Impairment of p53-Pathway in Chronic Lymphocytic Leukemia
- MICRORNA-34A IS SIGNIFICANTLY DOWN-REGULATED IN B-CLL PATIENTS WITH P53 ABNORMALITIES
- MICRORNAS EXPRESSION PATTERN IN AGGRESSIVE SUBTYPE OF CHRONIC LYMPHOCYTIC LEUKEMIA
- MISSENSE MUTATIONS LOCATED IN STRUCTURAL P53 DNA-BINDING MOTIFS ARE ASSOCIATED WITH EXTREMELY POOR SURVIVAL IN CHRONIC LYMPHOCYTIC LEUKEMIA
- Molekulárně-biologické přístupy mutační analýzy genu TP53 u onkologických pacientů.
- MONITORING OF MINIMAL RESIDUAL DISEASE IN MANTLE CELL LYMPHOMA
- MONITORING OF THE STATUS OF BOTH P53 ALLELES IN PATIENTS WITH B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA - RELEVANCE TO PROGNOSIS AND TREATMENT
- MUTATION STATUS OF ATM GENE IN CLL PATIENTS HARBORING DELETION 11Q OR TP53 DEFECT
- Mutational Analysis of Mir-29 Family Members in Chronic Lymphocytic Leukemia
- Mutational Analysis of TP53 Gene in Chronic Lymphocytic Leukemia: Comparison of Different Methodological Approaches
- MUTATIONS IN THE TP53 GENE SHOW FEATURES OF SOMATIC HYPERMUTATION PROCESS WITH PROMINENT DIFFERENCE BETWEEN IGHV MUTATED AND UNMUTATED CHRONIC LYMPHOCYTIC LEUKEMIA
- NEW PROGNOSTIC MARKERS OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) IN THE EVERYDAY HEMATOLOGICAL PRACTICE. A MULTICENTER ANALYSIS
- Next Generation Sequence Immunoprofiling of the T-Cell Repertoire in Chronic Lymphocytic Leukemia Supports Selection By Shared Antigenic Elements
- NOD/SCID GAMMA XENOGRAFT MODEL OF B-CELL MALIGNANCIES USING TP53- AND/OR ATM-DEFICIENT CELL LINES
- NOD/SCID IL2RGAMMA(-/-) XENOGRAFT MODEL FOR CHRONIC LYMPHOCYTIC LEUKEMIA
- NON-HODGKIN LYMPHOMA SUBTYPES CLASSIFICATION USING FOCUSED MICROARRAY
- NOT ALL IGHV3-21 CLL ARE EQUAL: SUBSET #2 DISPLAYS A DISTINCTIVE CLINICOBIOLOGICAL PROFILE WITH REMARKABLE SIMILARITIES TO SUBSET #169, ITS CLOSE IMMUNOGENETIC RELATIVE
- Novel Gene Mutations In Chronic Lymphocytic Leukemia: Prevalence and Clinical Implications In A Series Of 3185 Cases - Initial Results From The European Research Initiative On CLL
- Ofatumumab Added To Dexamethasone In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia. Results From a Phase II Study Of The Czech Leukemia Study Group For Life
- P53 Inactivation and Genomic Aberrations in Relation to Imatinib Resistance in Chronic Myeloid Leukemia
- PCR DETECTION OF NON-MTC T(11;14) TRANSLOCATIONS IN MANTLE CELL LYMPHOMA
- Personalized Modeling of Disease Evolution in CLL: Does Statistical Significance Translate into Predictive Accuracy?
- PRESENCE OF HETEROZYGOUS ATM DELETION MAY NOT BE CRITICAL FOR THE RESPONSE OF CLL CELLS TO FLUDARABINE
- PROGNOSIS OF RELAPSED CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AFTER COMBINED FLUDARABINE, CYCLOPHOSPHAMIDE AND RITUXIMAB (FCR) TREATMENT
- Prognostic Impact of NOTCH1 Hotspot Mutation in TP53-Mutated Patients with Chronic Lymphocytic Leukemia
- PROGNOSTICKÝ VÝZNAM HOT SPOT MUTACE GENU NOTCH1 U PACIENTŮ S CHRONICKOU LYMFOCYTÁRNÍ LEUKEMIÍ A SOUVISLOST S MOLEKULÁRNĚ BIOLOGICKÝMI MARKERY ONEMOCNĚNÍ
- Prognostický význam mutačního stavu genu TP53 u pacientů s B-buněčnou chronickou lymfocytární leukémií – význam monitorováni obou alel.
- Přítomnost heterozygotní delece ATM nedeterminuje odpověď CLL buněk na fludarabin
- REACTIVATION OF SELECTED P53 MUTANTS IN B-CELL TUMOR CELL LINES USING TARGETED SMALL MOLECULES
- REARRANGEMENT OF LAMBDA IMMUNOGLOBULIN LIGHT CHAIN IN CLL IS COUPLED WITH MIRNA-650 EXPRESSION
- Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-κB Deregulation in Aggressive Chronic Lymphocytic Leukemia
- REFINING PROGNOSIS OF CHRONIC LYMPHOCYTIC LEUKEMIA WITH SOMATICALLY HYPERMUTATED B-CELL RECEPTORS: A NOVEL PROGNOSTIC INDEX ON BEHALF OF THE EUROPEAN RESEARCH INITIATIVE ON CLL (ERIC)
- RELATIONSHIP BETWEEN THERAPY AND CLONAL EVOLUTION OF TP53 ABNORMALITIES IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
- Rituximab Sensitizes B-CLL Cells with Inactivated p53 to Fludarabine.
- RITUXIMAB SENSITIZES SOME B-CLL SAMPLES TO FLUDARABINE AND CHLORAMBUCIL IN VITRO, REGARDLESS OF P53/ATM STATUS
- Role of p53 Gene Mutation Type in B-CLL Prognosis
- ROLE OF WNT-5A AND NON-CANONICAL WNT SIGNALING IN CHRONIC LYMPHOCYTIC LEUKEMIA
- SENSITIZATION OF LEUKEMIC CELLS TO FLUDARABINE BY MONOCLONAL ANTIBODY RITUXIMAB - IDENTIFICATION OF RESPONSIBLE GENES
- Sequence Variations in miRNA Genes Are Common and May Affect Their Expression in Patients with Chronic Lymphocytic Leukemia
- SF3B1 Mutations Frequently Occur With Both ATM Mutations and TP53 Mutations In CLL Patients
- SF3B1 MUTATIONS IN CLL ARE ASSOCIATED WITH A DEFECTIVE DNA DAMAGE RESPONSE
- SF3B1 MUTATIONS IN CLL ARE FUNCTIONALLY EQUIVALENT TO ATM GENE ALTERATIONS AND CAUSE DEFECTIVE PUMA AND P21 UPREGULATION IN RESPONSE TO DNA DAMAGE
- Single Cell Analysis of IG Genes in CLL: Cases with Multiple IGH Rearrangements Are Constituted of Several Independent Clones Even When Indistinguishable By Flow Cytometry
- Single Cell Analysis Proves the Coexistence of NOTCH1 and TP53 Mutations within the Same Cancer Cells in Patients with Chronic Lymphocytic Leukemia
- Sledování exprese vybraných genů u pacientů s B-buněčnou chronickou lymfocytární leukémií – záchyt změny leukemického klonu vlivem terapie
- SROVNÁNÍ NEJČASTĚJI VYUŽÍVANÝCH METOD DETEKCE HOT SPOT MUTACE GENU NOTCH1 U PACIENTŮ S CHRONICKOU LYMFOCYTÁRNÍ LEUKEMIÍ
- STUDIUM FUNKCE SESTŘIHOVÝCH VARIANT AKTIVACÍ INDUKOVANÉ DEAMINÁZY U B BUNĚČNÝCH MALIGNIT
- STUDIUM KLONÁLNÍ KOMPOZICE CHRONICKÉ LYMFOCYTÁRNÍ LEUKEMIE S VÍCEČETNÝMI IMUNOGLOBULINOVÝMI PŘESTAVBAMI NA ÚROVNI JEDNOTLIVÝCH BUNĚK
- STUDIUM SELEKCE NEPŘÍZNIVÝCH GENOMICKÝCH ABNORMALIT V RELAPSU CHRONICKÉ LYMFOCYTÁRNÍ LEUKEMIE
- Subset-Specific Spectra of Recurrent Gene Mutations in Chronic Lymphocytic Leukemia with Stereotyped B-Cell Receptors
- SYNTHETIC LETHALITY IN P53 MUTATED B-CELL MALIGNANCIES: CHK-1 INHIBITION AND DNA-PK INHIBITION EFFECT IN CELL LINES AND PRIMARY CLL CELLS
- T(14;18) IN FOLLICULAR LYMPHOMA: A REAL- TIME (PCR) FOR A REAL LIFE….?
- T315I MUTATIONS ARE CLUSTERED WITH ADVANCED PHASES CONTRARY TO OTHER ABERRATIONS IN CML PATIENTS RESISTANT TO TKI THERAPY
- TARGETED NEXT-GENERATION SEQUENCING FOR MUTATIONAL SCREENING IN CHRONIC LYMPHOCYTIC LEUKEMIA: A HIGH-THROUGHPUT YET TAILORED APPROACH WILL FACILITATE IMPLEMENTATION WITHIN A CLINICAL SETTING
- The Composition of the B Cell Receptor Repertoire In 7428 Cases of Chronic Lymphocytic Leukemia: One Third Stereotyped, Two Thirds Heterogeneous - What Does This Mean?
- THE EXPRESSION OF A SINGLE MICRORNA - MIR-34A – IS A RELIABLE MARKER FOR IMPAIRMENT OF P53-PATHWAY IN CHRONIC LYMPHOCYTIC LEUKEMIA
- THE IMPACT OF SPECIFIC MUTATIONS IN TP53 GENE ON THE RESULTS OF ALEMTUZUMAB THERAPY IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS
- The Interlaboratory Robustness Of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses Of Hematological Malignancies Performed In 8,867 Cases By An International Network Involving 27 Laboratories
- The Mystery of FDG-PET Avidity In Follicular Lymphoma. Does Microenvironment Play the Key Role?
- The Regulation, Targets and Clinical Relevance of Microrna Mir-650 in Chronic Lymphocytic Leukemia (CLL)
- The Target Genes and Prognostic Significance of Mir-150 in Chronic Lymphocytic Leukemia
- TP53 Abnormalities in Chronic Lymphocytic Leukemia Exhibit a Disease Specific Profile: Meta-Analysis of 270 Mutations
- TP53 MUTATIONS BUT NOT ATM MUTATIONS ASSOCIATE WITH HIGHER IN VITRO RESISTANCE OF CLL CELLS TO RITUXIMAB
- Tp63 Contributes to the Apoptosis Resistant Phenotype in Aggressive Chronic Lymphocytic Leukemia
- Tracing the Ontogeny of IgG-Switched CLL: High-Throughput Immunogenetic Evidence
- TRANSLOCATION IS A FREQUENT MECHANISM FOR 17P DELETION IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
- TUMOR DYNAMICS OF CHRONIC LYMPHOCYTIC LEUKEMIA CASES WITH MULTIPLE PRODUCTIVE IGHV-IGHD-IGHJ REARRANGEMENTS
- Unique Versus Common: Disease-Biased Immunoglobulin Gene Repertoires Along with Public Antigen Receptor Stereotypes in Marginal Zone B-Cell Lymphoproliferations
- UPREGULATED COBLL1 IN CHRONIC LYMPHOCYTIC LEUKAEMIA (CLL) PATIENTS WITH UNMUTATED IGHV IDENTIFIES A COHORT WITH INFERIOR PROGNOSIS
- VYHLEDÁVÁNÍ A SLEDOVÁNÍ KLONŮ S MUTACÍ TP53 V CHRONICKÉ FÁZI MYELOPROLIFERATIVNÍCH NEOPLAZIÍ (MPN)
- Využití DNA microarrays v diagnostice lymfocytárních leukémií.
- Využití long-oligonucleotide arrayCGH v diagnostice leukémií.
- VYUŽITÍ NGS PŘI DIAGNOSTICE DĚDIČNÉ NÁDOROVÉ PREDISPOZICE
- Využití RNA interference při regulaci genové exprese antionkogenu p53
- Využití RNA interference při regulaci genové exprese antionkogenu p53
- WHAT CAN WE CURRENTLY LEARN FROM NEW PROGNOSTIC MARKERS OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) IN THE EVERYDAY HAEMATOLOGICAL PRACTICE?
- WHAT DO WE KNOW ABOUT THE REAL INCIDENCE OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND WHERE AND HOW ARE THE PATIENTS WITH CLL TREATED?
Články v Klinické onkologii
- Cytogenetické vyšetření lymfocytů periferní krve po stimulaci IL-2 a CpG oligonukleotidem DSP30 u pacientů s chronickou lymfocytární leukemií
- Encyklopedie subsetů CLL – unikátní bioinformatický nástroj a databáze pro analýzu subsetů stereotypních B buněčných receptorů u CLL
- Genetická diagnostika familiárních onemocnění krvetvorby
- Chromotripse – rozsáhlé chromozomové přestavby a jejich význam u onkologických onemocnění
- Identifikace rodiny s nosičstvím germinální delece genu SUFU na podkladě diagnózy desmoplastického meduloblastomu u batolete
- Molekulárně biologická diagnostika mutací genu KRAS a BRAF u pacientů s kolorektálním karcinomem – zkušenosti laboratorního pracoviště
- Molekulární prognostické markery chronické lymfocytární leukemie a jejich klinický význam
- Od genomu k proteomu využití proteinových čipů v onkologii
- Odběr a zpracování vzorků pro expresní DNA čipy
- Protein p21 WAF1 a jeho úloha v regulaci buněčného cyklu
- Proteomická analýza nádorových buněk
