Prof.MUDr. Jan Trka, Ph.D.

Publikovaná abstrakta

• Acute Leukaemias with TEL/ABL Fusion: a Subgroup with Poor Prognosis and Prenatal Origin
• Association of Asparagine Synthetase Expression and Sensitivity to L-Asparaginase in Cell Lines and Primary Pediatric Acute Lymphoblastic Leukemia Samples
• B Precursor ALL Subset with Aberrant CD2 Expression and a Specific Predisposition to Early Monocytic Transdifferentiation
• Backtracking Of The Genetic Events Preceding Acute Leukemia Diagnosis
• Biology of Childhood Acute Hybrid Leukemias in a Population-Based Study (Czech Pediatric Hematology Working Group).
• C20orf94 deletion Is Strongly Associated with TEL/AML1 Rearrangement and Links Illegitimate V(D)J Recombination with Gender Bias In Childhood Acute Lymphoblastic Leukemia
• Clinical Relevance of Complex Chromosomal Aberrations in Bone Marrow Cells of 107 Children with ETV6/RUNX1 Positive Acute Lymphoblastic Leukemia (ALL).
• Collaboration between Activating Mutations in JAK2 and Trisomy 21 in the Acute Lymphoblastic Leukemias of Down Syndrome (DS).
• COMPOSITION OF BONE MARROW SUBPOPULATIONS ANALYZED BY FLOW CYTOMETRY REVEALS DIFFERENCES BETWEEN PEDIATRIC APLASTIC ANEMIA AND REFRACTORY CYTOPENIA
• Defect in B Cell Production Driven By GATA2 Mutation Results in Their Absolute Reduction and Mature Phenotype in Pediatric Patients
• DIVERSE ASPARAGINE SYNTHETASE EXPRESSION IN LYMPHOID BLASTS IS NOT RELEVANT TO THE SENSITIVITY TO L-ASPARAGINASE
• DNA Methylation Profiling of Pediatric AML Reveals That Hypomethylation of MN1 Is Characteristic of Inv(16) AML and a Driver of MN1 Overexpression
• Druhá celostátní léčebná studie AML-BFM 98 zvýšila úspěšnost v dosažení remise i celkové přežití dětí s akutní myeloidní leukémií v České republice
• Effective Response Metric (ERM-D8) Using Time-Series Gene Expression Profiling at Diagnosis and Day 8 of Remission-Induction Therapy Is a Novel Early Prognostic Marker to Predict Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) — a Malaysia-Singapore ALL Study
• Epigenetic Changes in CEBPα Gene and Xenotransplantation Model of B Cell Precursor Acute Lymphoblastic Leukemia Switching to Monocytoid Lineage During the Early Phase of the Treatment
• Epigenetic Status Of CEBPA Promoter and Expression Of CEBPα Correlates With Molecular Genetic Subtype and CD2 Aberrant Expression In B Cell Precursor ALL
• Epor Over-Expression In TEL-AML1 Positive ALL: Critical Roles for DNA Methylation, GATA-2 or MicroRNAs?
• ETV6 Aberrations Are a Recurrent Event in Pediatric Acute Myeloid Leukemia with Poor Clinical Outcome
• ETV6/RUNX1 DIRECTLY DYSREGULATES GENES WITH RUNX1 BINDING SITE VIA MECHANISM REVERSIBLE BY HISTONE DEACETYLASE INHIBITORS
• ETV6/RUNX1 Dysregulates Genes with RUNX1 Binding Site Via Mechanism Reversible by Histone Deacetylase Inhibitors
• EVI1 Overexpression in Pediatric Acute Myeloid Leukemia Associated with Unfavorable Subtypes
• Exprese genu Wilmsova tumoru 1 (WT1) u testikulárních germinálních nádorů (TGCT)
• Expression of LAT and PAG Adaptor Molecules in Blasts of Childhood Acute Lymphoblastic Leukaemias and in Normal B- and T-Precursors
• Expression of Transmembrane Adaptors Is Specific in Distinct Childhood Acute Lymphoblastic Leukaemia Subgroups and Indicates Early Treatment Response in T-ALL.
• Expression Pattern of WT1 Isoforms in Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Severe Aplastic Anemia (SAA)
• EXPRESSION PATTERN OF WT1 ISOFORMS IN PATIENTS WITH CHILDHOOD AML
• Expression Profile of Selected HOX Genes in Different Childhood ALL Subtypes
• FREQUENCY AND CLINICAL IMPLICATIONS OF ADDITIONAL CHROMOSOMAL ABERRATIONS IN ETV6/RUNX1 POSITIVE CHILDHOOD ALL
• GENOMIC VS. GENE EXPRESSION-BASED METHODS IN THE DETECTION OF IKAROS (IKZF1) ALTERATIONS AND EVALUATION OF THEIR PROGNOSTIC IMPACT IN CHILDHOOD ALL
• HIGH GATA2 EXPRESSION IS A POOR PROGNOSTIC MARKER IN PEDIATRIC ACUTE MYELOID LEUKEMIA
• HOX Genes Expression Pattern Is Related to Phenotypical and Genotypical Subgroups but Not to Treatment Response in Pediatric ALL
• Changes Identified by Flow Cytometry and WT1 Expression in Consecutive Bone Marrow Samples in Refractory Cytopenia of Childhood and Aplastic Anemia Before Start of the Therapy
• Characterization of CEBPA Mutations and Promoter Hypermethylation in Pediatric Acute Myeloid Leukemia
• Characterization of Leukemias with ETV6-ABL1 Fusion
• IKZF1 DELETION STATUS DISCRIMINATES FOR OUTCOME IN IMATINIB-TREATED BCR-ABL1-POSITIVE CHILDHOOD ALL
• IKZF1 deletions in Pediatric Acute Myeloid Leukemia
• ILLEGITIMATE V(D)J - MEDIATED RECOMBINATION IS LINKED TO GENDER BIAS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
• IMMUNOGLOBULIN AND T CELL RECEPTOR REARRANGEMENTS IDENTIFICATION REVEALS POTENTIALLY NEW SUBGROUP WITHIN PEDIATRIC ACUTE BIPHENOTYPIC LEUKEMIAS
• IN UTERO ORIGINS OF CHILDHOOD LEUKAEMIA
• INTERNATIONAL MULTI-LABORATORY NEXT-GENERATION SEQUENCING FOR MRD ANALYSIS IN ALL. A PILOT STUDY BY THE EUROCLONALITY-NGS CONSORTIUM
• Inv(11)(q21q23) Fuses MLL to the NOTCH Co-Activator Mastermind-Like 2 in Secondary T Cell Acute Lymphoblastic Leukemia
• L-Asparaginase Causes Metabolic Reprogramming in ALL Cells
• L-Asparaginase More Effectively Targets Leukemic Cells with Low Glycolytic Activity
• L-Asparaginase Strongly Affects Bioenergetics in Leukemic Cells
• Leukemic Pattern Of HOX Gene Expression Is Driven By Genetic Aberrations Through Epigenetic Modifiers
• Library Preparation Is the Major Factor Affecting Differences in Results of Immunoglobulin Gene Rearrangements Detection on Two Major Next-Generation Sequencing Platforms
• Limited Reliability of Ig/TCR Based MRD Monitoring in BCR/ABL-Positive Childhood ALL: Comparison to Quantitative Fusion Transcript Detection
• Low Levels of Mir-151-5p and Mir-451 Predict Relapse in Pediatric B-Lineage Acute Lymphoblastic Leukemia
• Microrna-106b~25 Cluster Is Involved in Relapsed MLL-Rearranged Pediatric AML
• MINIMAL RESIDUAL DISEASE ANALYSIS IN NON-MRD BASED TREATMENT PROTOCOL FOR CHILDHOOD ALL: LOW RISK FEATURES TOGETHER WITH FAST MORPHOLOGICAL RESPONSE FAIL TO IDENTIFY SLOW-RESPONDERS WITHIN THE ALL IC-BFM 2002 STANDARD RISK GROUP
• MINIMAL RESIDUAL DISEASE IN PERIPHERAL BLOOD AT DAY 15 PREDICTS PROGNOSIS OF CHILDHOOD B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA AND REFINES RISK STRATIFICATION BASED ON BONE MARROW
• MINIMAL RESIDUAL DISEASE STRATIFICATION BY NEXT GENERATION SEQUENCING PROFILING OF IMMUNOGLOBULIN GENE REARRANGEMENTS AS AN ALTERNATIVE TO CLASSICAL QPCR-BASED TECHNIQUE IN CHILDHOOD ALL
• MLL Translocation in a Multipotent Progenitor Causing Acute Lymphoblastic Leukaemia Two-Step Model of the Disease
• MLL TRANSLOCATION IN A MULTIPOTENT PROGENITOR CAUSING ACUTE LYMPHOBLASTIC LEUKAEMIA - TWO-STEP MODEL OF THE DISEASE
• Modeling Resistance To Tyrosine Kinase Inhibitors In TEL/ABL-Positive Acute Lymphoblastic Leukemia
• MODELING RESISTANCE TO TYROSINE KINASE INHIBITORS IN TEL/ABL+ ACUTE LYMPHOBLASTIC LEUKEMIA
• Molecular Background of BCP-ALL Cases with an Early Switch to Monocytic Lineage
• MRD Monitoring Reveals a Specific Biology of BCR/ABL-Positive ALL
• MRD Monitoring Using Minor-BCR-ABL1 Genomic Breakpoint in Childhood ALL Identifies a Subgroup with Distinct Biology and a Very Poor Prognosis
• Multilevel Molecular Profiling to Dissect Resistance to Tyrosine Kinase Inhibitors in TEL/ABL Positive Acute Lymphoblastic Leukemia
• New Targets in Cytometric Investigation of Acute Leukemia Selected From Gene Profiling Studies
• Next Generation Amplicon Sequencing of Immunoglobulin Heavy Chain Gene Rearrangaments for Minimal Residual Disease (MRD) Stratification in Childhood Acute Lymphoblastic Leukemia (ALL): A Comparison with Classical qPCR-Based Technique
• NTAL Potentiates Glucocorticosteroid-Induced Apoptosis in T-ALL – in Vivo Observations and Experimental Model
• NUP98/JARID1A Is a New Recurrent Genetic Abnormality in Pediatric Acute Megakaryoblastic Leukemia with a Distinct HOX-Gene Expression Pattern
• Observational Study Alternating R-CHOP21 and R-Cytarabine (3+3 Cycles) for Patients with Newly Diagnosed Mantle Cell Lymphoma Not Eligible for High-Dose Therapy: A Czech Lymphoma Study Group Trial Preliminary Results
• PERIPHERAL BLOOD INVOLVEMENT PROVIDES AN IMPORTANT PROGNOSTIC INFORMATION DURING EARLY TIME POINTS OF CHILDHOOD ALL TREATMENT
• Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells
• Prediction of Relapse By microRNA Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia
• Prognosis of ProB ALL in Children
• Prognostic Impact of Ikaros (IKZF1) Gene Alterations In Childhood ALL Treated with ALL IC-BFM 2002 Protocol: A Comparison of Gene Expression and Genomic-Based Methods
• Prognostic Impact of Peripheral Blood Involvement during Early Time Points of Childhood ALL Treatment
• Prognostic Relevance of Recurrent Genetic Aberrations in Pediatric Acute Megakaryoblastic Leukemia
• Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study
• Prognóza proB ALL
• Přesmyk z lymfoidní do myeloidní linie během prednisonové předfáze u dětí léčených podle protokolu ALL IC BFM2002
• Relative Expression of Ikaros Isoforms Has a Prognostic Impact in Phildelphia-Negative Childhood Acute Lymphoblastic Leukemia
• Repeated Bone Marrow Aspiration At the End of Induction Therapy: Implications for Treatment Stratification in Paediatric Acute Lymphoblastic Leukaemia
• Results of the Randomized I-BFM-SG Trial „Acute Lymphoblastic Leukemia Intercontinental-BFM 2002“ in 5060 Children Diagnosed in 15 Countries on 3 Continents
• Retrospektivní analýza imunofenotypu subpopulací v kostní dřeni u dětí s myelodysplastickým syndromem a aplastickou anémií
• RNAI MEDITED SILENCING REVEALS TEL/AML1 IS DISPENSABLE FOR LEUKEMIC CLONE SURVIVAL
• Silencing of TEL/AML1 In Definitive Leukemic Cells Does Not Impair Cell Survival
• Standardized 4 Color Flow Cytometric Minimal Residual Disease Detection Failed To Overcome Regeneration Problems but Identifies Early Blast Clearence Predictive of Molecular Remission after Induction in Childhood B Lineage Leukemia
• Targeted Therapy of AML1/ETO-Positive AML Cells in Experimental Model
• Telomere Length and Telomerase Complex Mutations in Pediatric Acute Myeloid Leukemia
• The Central Region of TEL (ETV6) Is Dispensable for the TEL/AML1 (ETV6/RUNX1) Leukemogenesis
• THE MECHANISM UNDERLYING BIOLOGICAL EFFECT OF VALPROIC ACID IN TARGETED THERAPY OF AML1/ETO POSITIVE CELLS
• THE PREDICTIVE STRENGTH OF NEXT GENERATION SEQUENCING MINIMAL RESIDUAL DISEASE DETECTION FOR RELAPSE COMPARED WITH CURRENT METHODS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
• THE PREVALENCE OF GATA-2 MUTATION AMONG PEDIATRIC PATIENTS WITH MYELODYSPLASTIC SYNDROME IN CZECH REPUBLIC
• The Role of Histone Demethylases in the Transcription Regulation of HOX Genes in PML-RARa+ AML Patients
• TRACKING OF THE PRELEUKEMIC PERIOD IN SECONDARY ACUTE LEUKEMIAS REVEALS MULTIPOTENT PROGENITOR AS A TARGET OF MLL REARRANGEMENTS
• Treatment with Valproic Acid Restores Differentiation in AML1/ETO-Positive Leukaemic Cells.
• USE OF BCR/ABL GENOMIC BREAKPOINT FOR MRD MONITORING IN CHILDHOOD ALL AND ITS COMPARISON WITH OTHER STANDARD METHODS
• Validation of MRD Quantification By Flow Cytometry for Pediatric BCP ALL Relapsed Patients Treated on the Intreall Protocol
• Wilms’ Tumor 1 Gene Mutations in Childhood Acute Myeloid Leukemia: A New Prognostic factor with Implications for MRD Detection
• Wilms’ tumor gene 1 (WT1) aberrations in testicular germ cell tumors (TGCTs).
• WT1 Expression at the Diagnosis of Childhood AML Has No Prognostic Value but Corresponds with the Biological Characteristics of Leukemic Cells - Results From European Multicenter Study
• WT1 EXPRESSION IN PERIPHERAL BLOOD HAS NO PROGNOSTIC VALUE BUT CAN PROVIDE MORE USEFUL INFORMATION ON MRD COMPARED TO BM IN CHILDREN WITH AML