Doc.RNDr. Vladimír Divoký, Ph.D.

Publikovaná abstrakta

• A CASE REPORT WITH E6A2 BCR-ABL FUSION TRANSCRIPT WITH MARKED BASOPHILIA AND HIGH ACTIVATION OF SRC KINASES DOWNSTREAM BCR-ABL
• Antioxidant Status of Red Blood Cells Is a Modifying Factor of Clinical Manifestation of Unstable Hemoglobin Variant Hana [22 63 (E7) His-Asn)]
• Bcr-Abl-Independent Activation of Src Kinases Associated with Development of Dasatinib Resistance in a CML Patient
• Cdk2 Kinase Activity Is Not Abrogated after DNA Damage in Mouse Embryonic Stem Cells.
• CONSEQUENCES OF DMT1 MUTATION ON ERYTHROPOIESIS
• Decreased Rate of beta-GlobinL1 Allele Transcription Due to Intronic LINE-1 Insertion In the beta-Globin gene Is Associated with beta-globinL1 Promoter and Enhancer Hypermethylation Which Is Not Reverted by Decitabine
• Divalent Metal Transporter 1 (DMT1) Regulates EPO Receptor Gene Expression Via GATA-1
• DMT1-Mutant Erythrocytes Have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress
• DNA Damage Response Is a Barrier in the Mixed Lineage Leukemia Development
• Erythropoiesis and Iron Metabolism In Diamond-Blackfan Anemia
• Erythropoietin-Driven Signaling Complements the Survival Defect of DMT1-Mutant Erythroid Cells
• Evidence for An Anti-Cancer Barrier in a Mixed Lineage Leukemia Mouse Model in Vivo
• EVIDENCE FOR AN ANTI-CANCER BARRIER IN A MIXED LINEAGE LEUKEMIA MOUSE MODEL IN VIVO
• FIVE NEW CASES OF HEXOKINASE DEFICIENCY: BIOCHEMICAL AND MOLECULAR CHARACTERIZATION OF A NOVEL SPLICE SITE MUTATION AND 2 NOVEL MISSENSE MUTATIONS IN HK1.
• Histone γ-H2AX as a possible biomarker in Barrett´s Esophagus disease progression
• In mouse embryonic stem cells, Cdk2 does not localize to the nucleus but its activity contributes to a very short G1 phase
• INCREASED AND PROLONGED STAT5 ACTIVATION DETECTED FOR A JAK2 E846D GERMLINE MUTATION IN THE SPECIFIC CONTEXT OF EPO RECEPTOR
• INTRONIC LINE-1 INSERTION IN THE BETA-GLOBIN GENE CAUSES BETA-THALASSEMIA DUE TO ABERRANT SPLICING, NONSENSE-MEDIATED DECAY AND DECREASED RATE OF BETA-GLOBIN L1 ALLELE TRANSCRIPTION
• Iron Chelation Reinforces DNA Damage Response and Leads to G2/M Checkpoint Activation and Autophagy in Myeloid Bone Marrow Cells of Preleukemia Mouse Model
• JAK2 E846D Germline Mutation Associated with Erythrocytosis Causes Increased and Prolonged Epo-Induced Activation of STAT5
• JAK2 Genotyping (Real-Time Allelic Discrimination) Reveals Rare JAK2 V617F-Positive Erythroid Colonies in Pediatric Patients with Essential Thrombocythemia.
• Léčba dasatinibem u nemocných s CML rezistentních na imatinib: test sensitivity leukemických buněk pacientů na inhibitory kináz in vitro a in vivo.
• MODIFICATION OF PHENOTYPE OF UNSTABLE HEMOGLOBINOPATHY (HEMOGLOBIN HANA ALPHA2BETA2 63 (E7) HIS-ASN)]) BY PARTIAL GLUTATHIONE REDUCTASE DEFICIENCY
• MOLECULAR CHARACTERIZATION OF BETA-THALASSEMIA AND HEMOGLOBIN VARIANTS IN THE CZECH AND SLOVAK POPULATIONS: AN UPDATE
• Mutation Of The Divalent Metal Transporter (Dmt1) Gene Results In Inefficient Induction Of The Erythroid Transcriptional Program Due To Latter Onset Of GATA-1 and Epor Expression
• New Mutation in ALAS2 as the Cause of X-Linked Sideroblastic Anemia Responsive to Pyridoxine: Comparison of ALAS2-Defective and DMT1-Defective BFU-E Growth
• Number of PD-1+/CD8+ Cells in Peripheral Blood of Patients with Lymphoma Reflects Tumor Burden, Lymphoma Subtype, Disease Phase and Is Significantly Higher Compared to Healthy Volunteers
• Oxidative Stress and Increased Destruction of Red Blood Cells Contribute to the Pathophysiology of Anemia Caused By DMT1 Deficiency
• Polycythemia of Mice with Human Gain-of-Function EPOR (mtHEPOR) Is Transiently Corrected in Perinatal Life in Association with Low Epo and Increased Erythrocyte Phosphatidylserine Exposure
• Programmed Death-1 Ligand Is Uniformly Expressed On Primary Mediastinal Diffuse Large B-Cell Lymphoma Cells with No Influence On Patient Survival
• Přídatné chromosomové změny u pacientů s CML léčených preparátem Glivec
• RUNX1 and NF-E2 Transcriptional Upregulation Is Not Specific For Myeloproliferative Neoplasms But Is Seen In Those Polycythemic Disorders With Augmented HIFs Signaling
• Sensitivity and resistance of leukemia cells to imatinib and dasatinib in cml patients
• Sickle Cell Anemia in a Child with Three β-Globin Clusters (β-S/β-S, β-A): Loss of LCR and 3' HS1 in the Duplicated Wild-Type β-Globin Cluster Does Not Fully Abrogate Its Transcript
• Test sensitivity leukemických buněk na inhibitory kináz in vitro a jeho význam při rozhodování o léčbě imatinibem a dasatinibem u nemocných s CML
• THE ACTIVATING G537R MUTATION IN HIF2-ALPHA IS ASSOCIATED WITH IN VITRO HYPERSENSITIVITY OF ERYTHROID PROGENITORS TO ERYTHROPOIETIN
• The Potential Role of the Six1/Eya1 Pathway in the Establishment of Leukemia Stem Cells in MLL-ENL – Induced Leukemia
• USEFULNESS OF IN VITRO SENSITIVITY TESTING OF LEUKEMIC CELLS TO KINASE INHIBITORS FOR THE MANAGEMENT OF TREATMENT WITH IMATINIB AND DASATINIB IN CML PATIENTS