prof. MUDr. Jan Zuna, Ph.D.

Publikovaná abstrakta

• Acute Leukaemias with TEL/ABL Fusion: a Subgroup with Poor Prognosis and Prenatal Origin
• B Precursor ALL Subset with Aberrant CD2 Expression and a Specific Predisposition to Early Monocytic Transdifferentiation
• Backtracking Of The Genetic Events Preceding Acute Leukemia Diagnosis
• Biology of Childhood Acute Hybrid Leukemias in a Population-Based Study (Czech Pediatric Hematology Working Group).
• Clinical Relevance of Complex Chromosomal Aberrations in Bone Marrow Cells of 107 Children with ETV6/RUNX1 Positive Acute Lymphoblastic Leukemia (ALL).
• Clonal Origins of late Relapses in ETV6-RUNX1 Acute Lymphoblastic Leukemia
• Comparison of MRD Monitoring By IG/TR Rearrangement and BCR/ABL1 Transcript in Ph+ Pediatric Acute Lymphoblastic Leukemia Patients Treated with Imatinib in the Esphall Study
• DNA Based Detection and Quantification of BCR-ABL1 Gene Using Patient-Specific qPCR and Droplet Digital PCR Tests in Chronic Myeloid Leukemia
• Druhá celostátní léčebná studie AML-BFM 98 zvýšila úspěšnost v dosažení remise i celkové přežití dětí s akutní myeloidní leukémií v České republice
• Dynamics and Evolution of the Preleukemic Clone in Slow Onset Leukemias
• Epigenetic Changes in CEBPα Gene and Xenotransplantation Model of B Cell Precursor Acute Lymphoblastic Leukemia Switching to Monocytoid Lineage During the Early Phase of the Treatment
• ERG DELETION EXERTS A CD2-DEPENDENT POSITIVE PROGNOSTIC IMPACT ON IKZF1-DELETED CHILDHOOD ALL
• Expression of LAT and PAG Adaptor Molecules in Blasts of Childhood Acute Lymphoblastic Leukaemias and in Normal B- and T-Precursors
• Expression of Transmembrane Adaptors Is Specific in Distinct Childhood Acute Lymphoblastic Leukaemia Subgroups and Indicates Early Treatment Response in T-ALL.
• FREQUENCY AND CLINICAL IMPLICATIONS OF ADDITIONAL CHROMOSOMAL ABERRATIONS IN ETV6/RUNX1 POSITIVE CHILDHOOD ALL
• GENOMIC BCR-ABL1 FUSION CHARACTERISATION AND SNPS IDENTIFICATION UPSTREAM AND DOWNSTREAM OF THE BREAKPOINTS IN BCR AND ABL1 GENES OF CML PATIENTS USING NEXT GENERATION SEQUENCING
• Characterization of Leukemias with ETV6-ABL1 Fusion
• IMMUNOGLOBULIN AND T CELL RECEPTOR REARRANGEMENTS IDENTIFICATION REVEALS POTENTIALLY NEW SUBGROUP WITHIN PEDIATRIC ACUTE BIPHENOTYPIC LEUKEMIAS
• IN UTERO ORIGINS OF CHILDHOOD LEUKAEMIA
• International Standardization of Minimal Residual Disease Assessment for in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL) Expressing m-BCR-ABL Transcripts: Updated Results of Quality Control Procedures by the EWALL and ESG-MR
• INTERNATIONAL STANDARDIZATION OF MINIMAL RESIDUAL DISEASE ASSESSMENT FOR PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA EXPRESSING MINOR-BCR-ABL: UPDATED RESULTS OF EUROMRD
• Inv(11)(q21q23) Fuses MLL to the NOTCH Co-Activator Mastermind-Like 2 in Secondary T Cell Acute Lymphoblastic Leukemia
• Limited Reliability of Ig/TCR Based MRD Monitoring in BCR/ABL-Positive Childhood ALL: Comparison to Quantitative Fusion Transcript Detection
• MLL Translocation in a Multipotent Progenitor Causing Acute Lymphoblastic Leukaemia Two-Step Model of the Disease
• MLL TRANSLOCATION IN A MULTIPOTENT PROGENITOR CAUSING ACUTE LYMPHOBLASTIC LEUKAEMIA - TWO-STEP MODEL OF THE DISEASE
• Modeling Resistance To Tyrosine Kinase Inhibitors In TEL/ABL-Positive Acute Lymphoblastic Leukemia
• MODELING RESISTANCE TO TYROSINE KINASE INHIBITORS IN TEL/ABL+ ACUTE LYMPHOBLASTIC LEUKEMIA
• Molecular Background of BCP-ALL Cases with an Early Switch to Monocytic Lineage
• MOLECULAR CYTOGENETIC STUDY OF CHILDHOOD T-ALL
• MRD Monitoring Reveals a Specific Biology of BCR/ABL-Positive ALL
• MRD Monitoring Using Minor-BCR-ABL1 Genomic Breakpoint in Childhood ALL Identifies a Subgroup with Distinct Biology and a Very Poor Prognosis
• Multilevel Molecular Profiling to Dissect Resistance to Tyrosine Kinase Inhibitors in TEL/ABL Positive Acute Lymphoblastic Leukemia
• NTAL Potentiates Glucocorticosteroid-Induced Apoptosis in T-ALL – in Vivo Observations and Experimental Model
• Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells
• Přesmyk z lymfoidní do myeloidní linie během prednisonové předfáze u dětí léčených podle protokolu ALL IC BFM2002
• RAG-Mediated Recombination Is The Predominant Driver Of Oncogenic Rearrangement In ETV6-RUNX1 Acute Lymphoblastic Leukemia
• Repeated Bone Marrow Aspiration At the End of Induction Therapy: Implications for Treatment Stratification in Paediatric Acute Lymphoblastic Leukaemia
• Selected Adaptor Proteins NTAL, LAT, PAG, LIME Function in Proximal Signaling, Corticosteroid Driven Apoptosis and Expression of IKAROS Isoforms in the T-Leukemic Cells
• Selective Persistence of Distinct Stem/B Leukaemic Stem Cells In Childhood Acute Lymphoblastic Leukaemia In Clinical Remission
• The Central Region of TEL (ETV6) Is Dispensable for the TEL/AML1 (ETV6/RUNX1) Leukemogenesis
• The Genomic Landscape of TEL-AML1+ (ETV6-RUNX1) Acute Lymphoblastic Leukaemia
• TRACKING OF THE PRELEUKEMIC PERIOD IN SECONDARY ACUTE LEUKEMIAS REVEALS MULTIPOTENT PROGENITOR AS A TARGET OF MLL REARRANGEMENTS
• TRANSMEMBRANE ADAPTOR PROTEIN NTAL ENHANCES PROXIMAL SIGNALING AND POTENTIATES CORTICOSTEROID INDUCED APOPTOSIS IN T-ALL
• USE OF BCR/ABL GENOMIC BREAKPOINT FOR MRD MONITORING IN CHILDHOOD ALL AND ITS COMPARISON WITH OTHER STANDARD METHODS