Konference: 2006 31st Congress ESMO - účast ČR
Kategorie: Onkologická rizika a prevence
Téma: Prevention and screening
Číslo abstraktu: 962P
Autoři: MUDr. Dagmar Brančíková, Ph.D.; MUDr. Vladimír Spurný, CSc.; MUDr. Miroslava Sláviková; MUDr. Zdeněk Mechl, CSc.; MUDr. Otakar Bednařík, CSc.; MUDr. Renata Červená, Ph.D.; MUDr. Marek Slávik, Ph.D.
Patients after organ transplantation have high probability of
second cancer occurence. The incidence of malignant diseases is
increasing with longer survival of recipients and the admission of
older patients for transplantation programs and immunosupressive
treatment .
Material: between 2000-2004, 26 patients, with median age 61 years (32-70 ) were treated in our hospital.
15 pts waere after heart transplantation,
11 pts were ater kidney transplantation
Fifty percent of disease was diagnosed in the stage IV.
.
Time from transplantation to bursting of the new tumorr: 2-13 years, median 7 years.
Charasteristrics of the second tumors:
Skin cancer - 10 pts. - 5- SCC, 2- BCC, 1- SCC+BCC, melanoma malignum
sebaceous adenoCa - 2 pts. high stage
Colorectal cancer - 6 pts. - adenoCa (4x high grade, 2x low grade) 2pts with stage .III and 2 with stage IV
Breast cancer - 6 pts. (1male and 5 female)- ductal a lobular Ca high grade,2pts with stage IV and 3 pts st.III
other tumours - 4 pac.(tumour of the prostate, stomach, Grawitz , primum ignotum)
- (3 pts. high stage in the time of diagnosis )
Therapy:
skin tumours : surgery + RT
other tumours: surgery - chemotherapy - radiotherapy
12 pts chemotherapy only
Colorectal cancer chemotherapy
Breast cancer chemotherapy
Toxicity of chemotherapy:
- leucopenia G4 in 10 pts. (febril. neutropenia 3 case)
- gastrointestinal G4 in 4 pts
- hepatorenal insuficience gr 3/4 with 2 patients
The toxicity of chemotherapy is very relevant and progression of disease
Conclusions:
The patients after trasplantation are in high risk for incidence of malignancy.. These patients needs a very more precise follow-up, as 26 pacients out of 242.. with secondary malignancy represent a very serious number.
Material: between 2000-2004, 26 patients, with median age 61 years (32-70 ) were treated in our hospital.
15 pts waere after heart transplantation,
11 pts were ater kidney transplantation
Fifty percent of disease was diagnosed in the stage IV.
.
Time from transplantation to bursting of the new tumorr: 2-13 years, median 7 years.
Charasteristrics of the second tumors:
Skin cancer - 10 pts. - 5- SCC, 2- BCC, 1- SCC+BCC, melanoma malignum
sebaceous adenoCa - 2 pts. high stage
Colorectal cancer - 6 pts. - adenoCa (4x high grade, 2x low grade) 2pts with stage .III and 2 with stage IV
Breast cancer - 6 pts. (1male and 5 female)- ductal a lobular Ca high grade,2pts with stage IV and 3 pts st.III
other tumours - 4 pac.(tumour of the prostate, stomach, Grawitz , primum ignotum)
- (3 pts. high stage in the time of diagnosis )
Therapy:
skin tumours : surgery + RT
other tumours: surgery - chemotherapy - radiotherapy
12 pts chemotherapy only
Colorectal cancer chemotherapy
Breast cancer chemotherapy
Toxicity of chemotherapy:
- leucopenia G4 in 10 pts. (febril. neutropenia 3 case)
- gastrointestinal G4 in 4 pts
- hepatorenal insuficience gr 3/4 with 2 patients
The toxicity of chemotherapy is very relevant and progression of disease
Conclusions:
The patients after trasplantation are in high risk for incidence of malignancy.. These patients needs a very more precise follow-up, as 26 pacients out of 242.. with secondary malignancy represent a very serious number.
Datum přednesení příspěvku: 29. 6. 2006
