Hypoxia in prostate cancer

Hypoxia or low-oxygen conditions is a characteristic of a wide array of solid tumors, associated with tumor progression, neoangiogenesis and resistance to therapeutics. Unlike in vitro and animal studies, inconsistencies and unanswered questions exist regarding the role of hypoxia and angiogenesis in prostate cancer at the clinical level. Our talk will outline the role of hypoxia in prostate cancer, the domains where additional studies would be required and the therapeutic potential of targeting strategies.