2014 56th ASH Annual Meeting - účast ČR

101. Red Cells and Erythropoiesis, Structure and Function, Metabolism, and Survival, Excluding Iron: Poster III

Uncovering the Role of Heme Oxygenase 1 in the Pathophysiology of β-Thalassemia

Autoři: Daniel Garcia Santos, Ph.D.; Marc Mikhael, PhD; Mgr. Monika Horváthová, Ph.D.; M.D. Prem Ponka, Ph.D.
Číslo abstraktu: 1364
Kategorie: Myeloproliferativní nemoci

JAK2 E846D Germline Mutation Associated with Erythrocytosis Causes Increased and Prolonged Epo-Induced Activation of STAT5

Autoři: Mgr. Katarína Kapraľová; Mgr. Monika Horváthová, Ph.D.; Mgr. Jana Kučerová; doc.MUDr. Dagmar Pospíšilová, Ph.D.; Emilie Leroy; M.D. Stefan N. Constantinescu, Ph.D.; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 4008
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

102. Regulation of Iron Metabolism: Poster III

Oxidative Stress and Increased Destruction of Red Blood Cells Contribute to the Pathophysiology of Anemia Caused By DMT1 Deficiency

Autoři: Mgr. Zuzana Židová; Daniel Garcia Santos, Ph.D.; Mgr. Katarína Kapraľová; Mgr. Pavla Korálková (Pospíšilová); Mgr. Renata Mojzíková (Solná), Ph.D.; MvDr. Dalibor Doležal; M.D. Prem Ponka, Ph.D.; Doc.RNDr. Vladimír Divoký, Ph.D.; Mgr. Monika Horváthová, Ph.D.
Číslo abstraktu: 4027
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

201. Granulocytes, Monocytes and Macrophages: Poster II

High-Throughput Profiling of the T-Cell Receptor Gene Repertoire Supports Antigen Drive in the Pathogenesis of Chronic Idiopathic Neutropenia

Autoři: Evangelia Stalika; Anastasia Hadzidimitriou; Athanasios Gkoufas; Maria Karypidou; Semeli Mastrodimou; MD Anna Vardi, MSc.; Vasilis Bikos; Irene Mavroudi; prof. RNDr. Šárka Pospíšilová, Ph.D.; Dr. Achilles Anagnostopoulos; Nikos Maglaveras, M.Sc., PH.D.; Ioanna Chouvarda; Prof. MD Helen A. Papadaki, PhD; MD Kostas Stamatopoulos
Číslo abstraktu: 2731
Kategorie: Myeloproliferativní nemoci; Nádorová biologie/imunologie/genetika a buněčná terapie

203. Lymphocytes, Lymphocyte Activation and Immunodeficiency, including HIV and other Infection: Poster

Defect in B Cell Production Driven By GATA2 Mutation Results in Their Absolute Reduction and Mature Phenotype in Pediatric Patients

Autoři: MUDr. Michaela Nováková; MUDr. Aleš Janda, MSc; MD Marcin W. Wlodarski; MUDr. Martina Suková; MUDr. Vít Campr, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; MUDr. Eva Froňková, Ph.D.; MUDr. Elena Vodičková; MUDr. Ondřej Zapletal, Ph.D.; MUDr. Jan Blatný, Ph.D.; MUDr. Kateřina Lejhancová (Toušovská), Ph.D.; doc.MUDr. Dagmar Pospíšilová, Ph.D.; MUDr. Zdeňka Černá; MUDr.Mgr. Tomáš Kuhn; Doc.RNDr. Zuzana Zemanová, CSc.; Prof.MUDr. Jan Trka, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.; prof. MUDr. Jan Starý, DrSc.; MUDr. Ester Mejstříková, Ph.D.
Číslo abstraktu: 2746
Kategorie: Maligní lymfomy a leukémie

311. Disorders of Platelet Number or Function: Poster

PETIT and PETIT 2: Treatment with Eltrombopag in 171 Children with Chronic Immune Thrombocytopenia (ITP)

Autoři: MD James B. Bussel; M.D. John D. Grainger, BMBch, MRCP, FRCPATH; Purificacion Garcia de Miguel; Dr. Jenny M. Despotovic, DO, MS; Prof. MD Franco Locatelli, PhD; MD Thirachit Chotsampancharoen; Elena K. Donyush; MD Julian Sevilla Navarro; MD Bunchoo Pongtanakul; MD Patcharee Komvilaisak; MD Darintr Sosothikul; MD Victor S. Blanchette, FRCPC; MD Guillermo I. Drelichman; MD Lakshmanan Krishnamurti; MD Nongnuch Sirachainan; MD Philip Connor; MD Michele David, FRCPC; MD Susanne Holzhauer, MSc; Vladimir Lebedev; MD Richard S. Lemons, Ph.D.; doc.MUDr. Dagmar Pospíšilová, Ph.D.; MD Ugo Ramenghi; MD Koh B. Boayue; MD Dana C. Matthews; Lisa M. Marcello, BA, MS; Malini Iyengar, Ph.D.; MD Geoffrey (W.) Chan; MD Karen D. Chagin; MD Theodore Dickens, MPH; Kalpana K. Bakshi, BS, MS; Christine K. Bailey, Ph.D.
Číslo abstraktu: 1450
Kategorie: Myeloproliferativní nemoci

Final Results from a Phase 4 Open-Label 3-Year Study Evaluating Changes in Bone Marrow (Bm) Morphology in Adult Immune Thrombocytopenia (ITP) Patients (Pts) Receiving the Thrombopoietin Mimetic Romiplostim

Autoři: MD Ann Janssens; Francesco Rodeghiero; Dr. David Anderson; Beng Chong, MBBS FRCPA FRACP PhD; Zoltan Boda; Ingrid Pabinger; MUDr. Libor Červinek, Ph.D.; Xuena Wang; Angela Lopez
Číslo abstraktu: 2774
Kategorie: Myeloproliferativní nemoci

501. Hematopoietic Stem and Progenitor Biology: Poster III

Hematopoietic Stem and Progenitor Cells in Patients with Mature B-Cell Malignancies Are Quantitatively and Qualitatively Deregulated Compared to Healthy Controls

Autoři: MUDr. Bokang Calvin Maswabi; Ing. Dana Průková; MUDr. Jan Molinský; MUDr. Magdalena Klánová; MUDr. Lucie Latečková; M.D. Petra Vočková; Bc. Filipp Savvulidi; Mahmudul Alam, Ph.D.; Mgr. Dana Vejmělková; MUDr. Radek Jakša; RNDr. Luděk Šefc, CSc.; doc. MUDr. Martin Vokurka, CSc.; Prof. MUDr. Marek Trněný, CSc.; MUDr. Pavel Klener jr, Ph.D.; Mgr. Tomáš Zikmund
Číslo abstraktu: 4307
Kategorie: Maligní lymfomy a leukémie

601. Chromosomal Rearrangements and DNA Repair: Poster I

Clonal Heterogeneity in Patients with Myelodysplastic Syndromes (MDS) and Complex Karyotypes

Autoři: Doc.RNDr. Zuzana Zemanová, CSc.; prof. Ing. Kyra Michalová, DrSc.; RNDr. Jana Březinová, Ph.D.; Mgr. Halka Lhotská Buryová; Mgr. Karla Kostýlková Svobodová; RNDr. Iveta Šárová; RNDr. Libuše Lizcová; Mgr. Silvia Izáková; Mgr. Šárka Ransdorfová (Kurková), Ph.D.; Ing. Zdeněk Krejčík, Ph.D.; Mgr. Monika Běličková; MUDr. Magda Šišková, CSc.; doc. MUDr. Anna Jonášová, Ph.D.; doc. MUDr. Radana Neuwirtová, CSc.; Mgr. Jana Žmolíková; prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 859
Kategorie: Myelodysplastický syndrom

602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Molecular Mechanisms of Myeloid Malignancy

C/EBPα and MiR-182 Generate a Negative Feedback Loop Which Is Dysregulated in Acute Myeloid Leukemia

Autoři: Alexander Arthur Wurm; Dennis Gerloff; Daniela Braeuer-Hartmann; Christiane Katzerke; Jens-Uwe Hartmann; MD Stephan Fricke; Nadja Hilger; Meritxell Alberich-Jorda, PhD; Daniel G. Tenen; MD Dietger W Niederwieser; MD Gerhard Behre
Číslo abstraktu: 776
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Poster

Molecular Background of BCP-ALL Cases with an Early Switch to Monocytic Lineage

Autoři: Mgr. Karel Fišer, Ph.D.; MUDr. Lucie Slámová; Alena Dobiášová; Mgr. Júlia Starková, Ph.D.; MUDr. Eva Froňková, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; MUDr. Kamila Polgárová; MD Maria E. Figueroa; prof. MUDr. Tomáš Kalina, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Starý, DrSc.; Prof. MUDr. Ondřej Hrušák, Ph.D.; MUDr. Ester Mejstříková, Ph.D.
Číslo abstraktu: 3562
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

DNA Methylation Profiling of Pediatric AML Reveals That Hypomethylation of MN1 Is Characteristic of Inv(16) AML and a Driver of MN1 Overexpression

Autoři: Nicole S.D. Larmonie; MD Marry M. van den Heuvel-Eibrink, PhD; Askar Obulkasim; MD Valerie de Haas, Ph.D.; MD Dirk Reinhardt, PhD; Martin Zimmermann, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; MD Andre Baruchel, PhD; W. Ronald Stam; Prof. MD Rob Pieters, PhD; Maarten W.J. Fornerod, Ph.D.; MD Christian Michel Zwaan, PhD
Číslo abstraktu: 867
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

The Role of Histone Demethylases in the Transcription Regulation of HOX Genes in PML-RARa+ AML Patients

Autoři: Bc. Kateřina Rejlová; Mgr. Karolina Škvárová Kramarzová, Ph.D.; Meritxell Alberich-Jorda, PhD; Mgr. Karel Fišer, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Mgr. Júlia Starková, Ph.D.
Číslo abstraktu: 876
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

605. Molecular Pharmacology, Drug Resistance – Lymphoid and Other Diseases: Poster

Multilevel Molecular Profiling to Dissect Resistance to Tyrosine Kinase Inhibitors in TEL/ABL Positive Acute Lymphoblastic Leukemia

Autoři: MUDr. Olga Zimmermannová; Mgr. Veronika Kanderová; Mgr. Daniela Kužílková; MD Fridtjof Lund-Johansen, PhD; Mgr. Eliška Doktorová; RNDr. Jiří Petrák, CSc.; MD J.H. Frederik Falkenburg, Ph.D.; prof. MUDr. Tomáš Kalina, Ph.D.; Mgr. Júlia Starková, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.
Číslo abstraktu: 3637
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

MCL1 Targeting Agent Homoharringtonine Exerts Strong Cytotoxicity Towards Diffuse Large B-Cell Lymphoma (DLBCL) Cells and Synergizes with BCL2 Targeting Agent ABT199 in Eliminating BCL2-Positive DLBCL Cells

Autoři: MUDr. Magdalena Klánová; RNDr. Ladislav Anděra, CSc.; MUDr. Jan Soukup, Ph.D.; Mgr. Jan Bražina; Mgr. Jan Švadlenka; Mgr. Simona Benešová; Ing. Dana Průková; Mgr. Dana Vejmělková; MUDr. Radek Jakša; Ing. Karel Helman; M.D. Petra Vočková; MUDr. Lucie Latečková; MUDr. Jan Molinský; MUDr. Bokang Calvin Maswabi; Mahmudul Alam, Ph.D.; prof. MUDr. Roman Kodet, CSc.; Prof. MUDr. Marek Trněný, CSc.; MUDr. Pavel Klener jr, Ph.D.
Číslo abstraktu: 3645
Kategorie: Maligní lymfomy a leukémie

Discovery of Novel Drug Sensitivities in T-Prolymphocytic Leukemia (T-PLL) By High-Throughput Ex Vivo Drug Testing and Genetic Profiling

Autoři: Emma I. Andersson, MSc.; MD Leopold Sellner; Malgorzata Oles; Tea Pemovska, MSc.; Paavo Pietarinen, MSc.; M.D. Anneli Lauhio; Katarzyna Tomska; MD Carlos Cuesta-Mateos, PhD; prof. MUDr. Edgar Faber, CSc.; MD Tim H. Brummendorf, PhD; M.D. Olli Kallioniemi, Ph.D.; MD Kimmo Porkka, PhD; Caroline Heckman, Ph.D.; Wolfgang Huber, PhD; Krister Wennerberg, Ph.D.; Prof. Dr. med. Thorsten Zenz; MD Satu Mustjoki, PhD
Číslo abstraktu: 917
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

L-Asparaginase Causes Metabolic Reprogramming in ALL Cells

Autoři: Mgr. Ivana Heřmanová; Mgr. Karel Vališ, Ph.D.; Mgr. Hana Nůsková; Meritxell Alberich-Jorda, PhD; Amaia Arruabarrena Aristorena; Sonia Fernández-Ruiz; Simona Bártová; Alena Pecinová; RNDr. Daniel Kavan, Ph.D.; Mgr. Karel Fišer, Ph.D.; Ing. Marek Kuzma, Ph.D.; RNDr. Petr Novák, Ph.D.; RNDr. Tomáš Mráček, Ph.D.; Arkaitz Carracedo, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Mgr. Júlia Starková, Ph.D.
Číslo abstraktu: 922
Kategorie: Maligní lymfomy a leukémie

612. Acute Lymphoblastic Leukemia: Clinical Studies II

Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study

Autoři: Judith M. Boer, PhD; MD Arian Van Der Veer, PhD; Dimitris Rizopoulos, Ph.D.; Marta Fiocco, PhD; Edwin Sonneveld, PhD; Hester A. de Groot-Kruseman, PhD; Roland P. Kuiper, PhD; MD Peter M. Hoogerbrugge, PhD; MD Martin A. Horstmann, PhD; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Chiara Palmi; Prof.MUDr. Jan Trka, Ph.D.; MUDr. Eva Froňková, Ph.D.; Mariana Emerenciano, PhD; Maria do Soccoro Pombo-de-Oliveira, PhD; MD Wojciech Mlynarski, PhD; MD Tomasz Szczepanski, PhD; Karin Nebral, PhD; MD Andische Attarbaschi, PhD; Nicola C. Venn, PhD; Rosemary Sutton, PhD; BSc Claire Schwab; Amir Enshaei, PhD; prof. MUDr. Ajay J. Vora, MD, FRCP, FRCPath; MD Martin Stanulla, MSc; MD Martin Schrappe; Giovanni (Gianni) Cazzaniga, PhD; MD Valentino Conter, PhD; Martin Zimmermann, Ph.D.; Anthony V. Moorman, PhD; Prof. MD Rob Pieters, PhD; Monique L. den Boer, PhD, MSc
Číslo abstraktu: 368
Kategorie: Maligní lymfomy a leukémie

613. Acute Myeloid Leukemia: Clinical Studies: Pathophysiology and Prognosis

Clinical Impact of Additional Cytogenetic Aberrations, cKIT- and RAS Mutations and Other Factors in Pediatric t(8;21)-AML

Autoři: M.D. Kim Klein; MD Gertjan (J.L.) Kaspers, PhD; PhD Christine J. Harrison, FRCPath; H.Berna Beverloo, PhD; Ardine Reedijk, MSc; Mathilda Bongers, MSc; Jacqueline Cloos, Ph.D.; Prof. MD Andrea Pession; MD Dirk Reinhardt, PhD; Martin Zimmermann, Ph.D.; MD Ursula Creutzig, PhD; Prof. MD Michael Dworzak; Prof. Todd Allen Alonzo, PhD; MD Donna Johnston, FRCP; MUDr. Michal Zápotocký; MD Barbara De Moerloose; MD Alcira Fynn; MD Vincent Lee, PhD; MD Takashi Taga; MD Akio Tawa, PhD; MD Anne Auvrignon; Bernward Zeller; MD Carmen Salgado, PhD; MD Walentyna Balwierz, PhD; Alexander Popa; MD Jeffrey Rubnitz, PhD; Brenda Gibson
Číslo abstraktu: 481
Kategorie: Maligní lymfomy a leukémie

616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster I

Clofarabine in Combination with High-Dose Cytarabine and Liposomal Daunorubicin in Pediatric AML: Results of a Phase 1B Combination Study By the ITCC Consortium

Autoři: MD Christian Michel Zwaan, PhD; Prof. MD Michael Dworzak; M.D. Thomas Klingebiel; M.D. Claudia Rossig; M.D. Guy Leverger; prof. MUDr. Jan Starý, DrSc.; MD Eveline S.J.M. de Bont, PhD; Satianand Ramnarain, MSc; M.D. Yves Bertrand; MD Benoit Brethon; MD Brigitte Strahm; MD Gertjan (J.L.) Kaspers, PhD; MD Dirk Reinhardt, PhD
Číslo abstraktu: 989
Kategorie: Maligní lymfomy a leukémie; Nádory dětského a adolescentního věku

617. Acute Myeloid Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Genetic Mutations in Association: Novel Insights

DNMT3A is a Powerful Follow-up Marker in NPM1 mutated AML

Autoři: Prof. Dr. Susanne Schnittger, PhD; MD Claudia Haferlach; Tamara Alpermann; Niroshan Nadarajah, MSc; Manja Meggendorfer, PhD; Karolina Perglerová; M.D. Wolfgang Kern; MD Torsten Haferlach
Číslo abstraktu: 122
Kategorie: Maligní lymfomy a leukémie

617. Acute Myeloid Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Insights From NGS And Functional Studies

In AML Secondary to MDS NPM1 Mutations Are Late Events, Less Frequent, and Associated with a Different Pattern of Molecular Mutations Than in De Novo AML

Autoři: Prof. Dr. Susanne Schnittger, PhD; MD Claudia Haferlach; Niroshan Nadarajah, MSc; Tamara Alpermann; Manja Meggendorfer, PhD; Karolina Perglerová; M.D. Wolfgang Kern; MD Torsten Haferlach
Číslo abstraktu: 700
Kategorie: Maligní lymfomy a leukémie

617. Acute Myeloid Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster

ETV6 Aberrations Are a Recurrent Event in Pediatric Acute Myeloid Leukemia with Poor Clinical Outcome

Autoři: MD Jasmijn D.E. de Rooij; Eva Beuling, PhD; Maarten W.J. Fornerod, Ph.D.; Askar Obulkasim; MD Andre Baruchel, PhD; Prof.MUDr. Jan Trka, Ph.D.; MD Dirk Reinhardt, PhD; Edwin Sonneveld, PhD; Martin Zimmermann, Ph.D.; Prof. MD Rob Pieters, PhD; MD Marry M. van den Heuvel-Eibrink, PhD; MD Christian Michel Zwaan, PhD
Číslo abstraktu: 1012
Kategorie: Maligní lymfomy a leukémie

Genetic Patterns of Relapsed AML Differ Significantly from First Manifestation and Are Dependent on Cytogenetic Risk Groups at Diagnosis: Results in 175 Patients with Paired Samples

Autoři: Manja Meggendorfer, PhD; Tamara Alpermann; Karolina Perglerová; M.D. Wolfgang Kern; Prof. Dr. Susanne Schnittger, PhD; MD Claudia Haferlach; MD Torsten Haferlach
Číslo abstraktu: 1029
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Microrna-106b~25 Cluster Is Involved in Relapsed MLL-Rearranged Pediatric AML

Autoři: Lonneke Verboon; Maarten W.J. Fornerod, Ph.D.; Askar Obulkasim; Edwin Sonneveld, PhD; MD Andre Baruchel, PhD; Prof.MUDr. Jan Trka, Ph.D.; MD Dirk Reinhardt, PhD; Prof. MD Rob Pieters, PhD; Jacqueline Cloos, Ph.D.; MD Gertjan (J.L.) Kaspers, PhD; MD Jan-Henning Klusmann; MD Christian Michel Zwaan, PhD; MD Marry M. van den Heuvel-Eibrink, PhD
Číslo abstraktu: 1038
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

IKZF1 deletions in Pediatric Acute Myeloid Leukemia

Autoři: MD Jasmijn D.E. de Rooij; Eva Beuling, PhD; MD Christian Michel Zwaan, PhD; Askar Obulkasim; MD Andre Baruchel, PhD; Prof.MUDr. Jan Trka, Ph.D.; MD Dirk Reinhardt, PhD; Edwin Sonneveld, PhD; Brenda Gibson; Martin Zimmermann, Ph.D.; Prof. MD Rob Pieters, PhD; MD Marry M. van den Heuvel-Eibrink, PhD; Maarten W.J. Fornerod, Ph.D.
Číslo abstraktu: 2346
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie; Nádory dětského a adolescentního věku

Complexity of CEBPA Mutated Acute Myeloid Leukemia

Autoři: Annette Fasan, PhD; MD Claudia Haferlach; Karolina Perglerová; M.D. Wolfgang Kern; MD Torsten Haferlach; Prof. Dr. Susanne Schnittger, PhD
Číslo abstraktu: 2348
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Cytogenetic and Molecular Genetic Shifts in 27 Genes Investigated By NGS Depict Specific Routes from MDS to s-AML in 38 Patients with Paired Samples

Autoři: Andreia De Albuquerque, PhD; Manja Meggendorfer, PhD; M.D. Wolfgang Kern; Karolina Perglerová; Tamara Alpermann; MD Claudia Haferlach; Prof. Dr. Susanne Schnittger, PhD; MD Torsten Haferlach
Číslo abstraktu: 2378
Kategorie: Maligní lymfomy a leukémie

Specific Patterns of Molecular Mutations Determine the Morphologic Differentiation Stages in Acute Myeloid Leukemia (AML)

Autoři: Dominic Rose, PhD; MD Torsten Haferlach; Prof. Dr. Susanne Schnittger, PhD; Karolina Perglerová; M.D. Wolfgang Kern; MD Claudia Haferlach
Číslo abstraktu: 2388
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster

Effective Response Metric (ERM-D8) Using Time-Series Gene Expression Profiling at Diagnosis and Day 8 of Remission-Induction Therapy Is a Novel Early Prognostic Marker to Predict Relapse in Childhood Acute Lymphoblastic Leukemia (ALL) — a Malaysia-Singapore ALL Study

Autoři: M.D. Allen Eng Juh Yeoh; Zhenhua Li, PhD; Difeng Dong, PhD; Yi Lu, PhD; Prof.MUDr. Jan Trka, Ph.D.; Shirley Kow Yin Kham, BSc; M.D. Ah Moy Tan; Prof. Dr. Hany Ariffin; Limsoon Wong, PhD
Číslo abstraktu: 2393
Kategorie: Maligní lymfomy a leukémie

Next Generation Amplicon Sequencing of Immunoglobulin Heavy Chain Gene Rearrangaments for Minimal Residual Disease (MRD) Stratification in Childhood Acute Lymphoblastic Leukemia (ALL): A Comparison with Classical qPCR-Based Technique

Autoři: MUDr. Michaela Kotrová; Ing. Kateřina Mužíková; MUDr. Ester Mejstříková, Ph.D.; MUDr. Michaela Nováková; Mgr. Violeta Bakardjieva-Mihaylova; Mgr. Karel Fišer, Ph.D.; Mgr. Jan Stuchlý; Dr. Christianne Pott, PhD; MD Monika Brüggemann (Bruegemann), PhD; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; MUDr. Eva Froňková, Ph.D.
Číslo abstraktu: 2395
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie; Nádory dětského a adolescentního věku

Potential Involvement of Physiological TCR Gamma Delta Clones in Immune Surveillance of Preleukemic Cells

Autoři: MUDr. Olga Zimmermannová; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Anthony V. Moorman, PhD; MUDr. Eva Froňková, Ph.D.; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Tomáš Kalina, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 3775
Kategorie: Maligní lymfomy a leukémie

Comparison of MRD Monitoring By IG/TR Rearrangement and BCR/ABL1 Transcript in Ph+ Pediatric Acute Lymphoblastic Leukemia Patients Treated with Imatinib in the Esphall Study

Autoři: Giovanni (Gianni) Cazzaniga, PhD; Paola de Lorenzo, PhD; Anders Castor; Hans O Madsen; MD Virginie Gandemer; Dr. Helene Cavé; Prof. MD Rob Pieters, PhD; Vincent H.J. Van der Velden, PhD; prof. MUDr. Jan Starý, DrSc.; prof. MUDr. Jan Zuna, Ph.D.; MD Gabriele Escherich; Udo zur Stadt; Silja Röttgers; Dr. Julia Alten; Dr. Jeremy Hancock, Ph.D.; Giulia Ferrari; Maurizio Arico; Prof. Vaskar Saha, PhD, FRCP, FRCPath; MD Martin Schrappe; Prof. Maria Grazia Valsecchi, PhD; MD Andrea Biondi
Číslo abstraktu: 3782
Kategorie: Maligní lymfomy a leukémie

Refinement of IKZF1 Genomic Status in Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Autoři: Tobia Lana; Paola de Lorenzo, PhD; Silvia Bresolin, PhD; Ilaria Bronzini, Ph.D.; Monique L. den Boer, PhD, MSc; Dr. Helene Cavé; MUDr. Eva Froňková, Ph.D.; MD Martin Stanulla, MSc; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; PhD Christine J. Harrison, FRCPath; Hester A. de Groot-Kruseman, PhD; BSc Claire Schwab; Prof. Maria Grazia Valsecchi, PhD; MD Andrea Biondi; MD Giuseppe Basso; Giovanni (Gianni) Cazzaniga, PhD; Dr. Geertruy (Gertruuy) Te Kronnie, PhD
Číslo abstraktu: 3785
Kategorie: Maligní lymfomy a leukémie

Recovery of the Normal B-Cell Compartment in Children Treated for B-Cell Precursor Acute Lymphoblastic Leukemia

Autoři: Prisca Theunissen; MUDr. Ester Mejstříková, Ph.D.; MD Tomasz Szczepanski, PhD; Lukasz Sedek, PhD; Alita van der Sluijs; Dr. Alberto Orfao, PhD; MD Jacques J.M. van Dongen, PhD; Vincent H.J. Van der Velden, PhD
Číslo abstraktu: 3792
Kategorie: Maligní lymfomy a leukémie

Prediction of Relapse By microRNA Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia

Autoři: Prof. M.D. Isaac Yaniv; MD Asaf Lebel; Keren Shichrur, PhD; Oshrit Kordi; Anat Ohali, PhD; Michal Hameiri-Grossman; Iedan R.N. Verly; MD Gertjan (J.L.) Kaspers, PhD; Jacqueline Cloos, Ph.D.; MUDr. Eva Froňková, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Drorit Luria, PhD; Yona Kodman; Hadar Mirsky; Dafna Gaash; Marta Jeison, PhD; MD Galia Avrahami; MD Sarah Elitzur; MD Gil Gilad; MD Batia Stark; Smadar Avigad, PhD
Číslo abstraktu: 3793
Kategorie: Maligní lymfomy a leukémie

618. Acute Lymphoblastic Leukemia: Molecular Genetic Studies

The Strong Prognostic Effect of Concurrent Deletions of IKZF1 and PAX5, CDKN2A, CDKN2B or PAR1 in the Absence of ERG Deletions (IKZF1plus) in Pediatric Acute Lymphoblastic Leukemia Strongly Depends on Minimal Residual Disease Burden after Induction Treatment

Autoři: Elif Dagdan; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Petra Dörge, PhD; MD Anja Möricke; Martin Zimmermann, Ph.D.; Andrea Teigler-Schlegel, PhD; Prof. MD Claus R. Bartram; Dr. phil. nat. Rolf Koehler, PhD; MD Richard Ratei; Prof. Dr. med. Wolf-Dieter Ludwig; Dr. Julia Alten; Dr. med. Denis Martin Schewe; Prof. M.D. Christian Kratz; Prof. Richard S. Houlston; MD Jean-Pierre Bourquin, PhD; MD Andrea Biondi; Giovanni (Gianni) Cazzaniga, PhD; MD Giuseppe Basso; Dr. Geertruy (Gertruuy) Te Kronnie, PhD; Dr. Marie-Laure Yaspo; MD Martin Schrappe; MD Gunnar Cario; MD Martin Stanulla, MSc
Číslo abstraktu: 131
Kategorie: Maligní lymfomy a leukémie

622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Poster I

A Comprehensive Cytogenetic and Molecular Genetic Characterization of Patients with T-PLL Revealed Two Distinct Genetic Subgroups and JAK3 Mutations As an Important Prognostic Marker

Autoři: Anna Stengel, PhD; M.D. Wolfgang Kern; Melanie Zenger; Karolina Perglerová; Prof. Dr. Susanne Schnittger, PhD; MD Torsten Haferlach; MD Claudia Haferlach
Číslo abstraktu: 1639
Kategorie: Maligní lymfomy a leukémie

Tumor Cell Proliferation (Ki-67 Index) Overcomes Cytology and Growth Pattern As Prognostic Factor in Mantle-Cell Lymphoma – Results from Randomized Trials of the European MCL Network

Autoři: Eva Hoster; MD Andreas Rosenwald, PhD; MD Francoise Berger; Heinz-Wolfram Bernd; Sylvia Hartmann; Christoph Loddenkemper; Thomas Barth; Nicole Brousse; Stefano Pileri; Grzegorz Rymkiewicz; prof. MUDr. Roman Kodet, CSc.; MD Michael Unterhalt, PhD; Johanna C. Kluin-Nelemans; Prof. Olivier Hermine, M.D., PhD; MD Wolfgang Hiddemann; MD Martin H. Dreyling, Ph.D.; MD Wolfram Klapper, PhD
Číslo abstraktu: 2977
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

623. Lymphoma: Chemotherapy, excluding Pre-Clinical Models: Hodgkin Lymphoma/ T-cell Lymphoma

Addition of Rituximab to BEACOPPescalated to Improve the Outcome of Early Interim PET Positive Advanced Stage Hodgkin Lymphoma Patients: Second Planned Interim Analysis of the HD18 Study

Autoři: MD Peter Borchmann, PhD; Heinz Haverkamp; MD Andreas Lohri; MD Stefanie Kreissl; MD Richard Greil, Ph.D.; MUDr. Jana Marková; MD Michaela Feuring-Buske; Dr.med. Julia Meissner; M.D. Ulrich Dührsen (Duehrsen); MD Nicole Engel; MD Ulrich Keller; MD Georg Maschmeyer; MD Markus Dietlein; MD Carsten Kobe; MD Michael Fuchs; MD Volker Diehl; Prof. MD Andreas Engert
Číslo abstraktu: 500
Kategorie: Maligní lymfomy a leukémie

623. Lymphoma: Chemotherapy, excluding Pre-Clinical Models: Poster

Observational Study Alternating R-CHOP21 and R-Cytarabine (3+3 Cycles) for Patients with Newly Diagnosed Mantle Cell Lymphoma Not Eligible for High-Dose Therapy: A Czech Lymphoma Study Group Trial Preliminary Results

Autoři: MUDr. Pavel Klener jr, Ph.D.; MUDr. Eva Froňková, Ph.D.; MUDr. Robert Pytlík, Ph.D.; RNDr. Markéta Kalinová, Ph.D.; RNDr. Kristýna Forsterová; MUDr. David Belada, Ph.D.; MUDr. Martin Šimkovič; MUDr. David Šálek, Ph.D.; MUDr. Heidi Móciková, Ph.D.; MUDr. Vít Procházka, Ph.D.; MUDr. Vít Campr, Ph.D.; MUDr. Radek Jakša; MUDr. Jozef Kubinyi, Ph.D., FEBNM; Ass.Prof. MUDr. Jiří Doležal, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 1720
Kategorie: Maligní lymfomy a leukémie

Prognostic Impact of Interim and Final PET in Primary Mediastinal Large B-Cell Lymphoma Treated with Intensive Etoposide-Based Therapy

Autoři: MUDr. Vít Procházka, Ph.D.; MUDr. Lenka Henzlová; MUDr. Eva Buriánková; as. MUDr. Zuzana Prouzová; MUDr. Aleš Obr; RNDr. Martin Novák; MUDr. Jiří Minařík, Ph.D. ; prof. MUDr. Karel Indrák, DrSc.; doc. MUDr. Tomáš Papajík, CSc.
Číslo abstraktu: 1729
Kategorie: Maligní lymfomy a leukémie

Efficacy and Safety of Frontline Bortezomib, Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (VR-CAP) Vs R-CHOP in a Subset of Newly Diagnosed Mantle Cell Lymphoma (MCL) Patients (Pts) Medically Eligible for Transplantation in the Randomized Phase 3 LYM-3002 Study (NCT00722137)

Autoři: Johannes Drach; MD Huiqiang Huang, PhD; MD Olga S Samoilova; prof. MD Andrew Belch; MD Charles Michael Farber, PhD, FACP; MD Andre Bosly, PhD; MD Jan Novák, Ph.D.; MD Jan Zaucha, Ph.D.; MD Angela Dascalescu, PhD; MD Udomsak Bunworasate; MD Zvenyslava Masliak, PhD; MD Kateryna Vilchevskaya, PhD; MD Tadeusz Robak, PhD.; Lixia Pei, PhD; Brendan Rooney, PhD; MD Helgi van de Velde, PhD; Prof. MD Franco Cavalli, FRCP
Číslo abstraktu: 3064
Kategorie: Maligní lymfomy a leukémie

Bortezomib (Btz) Dose Intensity Is the Strongest Predictor for Overall Survival (OS) in Mantle Cell Lymphoma (MCL) Patients (Pts) Not Considered for Transplantation, Receiving Frontline Btz Plus Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (VR-CAP) Therapy in the Phase 3 LYM-3002 Study

Autoři: MD Tadeusz Robak, PhD.; MD Huiqiang Huang, PhD; MD Jie Jin, PhD; MD Jun Zhu; Ting Liu; MD Olga S Samoilova; MD Halyna Pylypenko; Prof. Dr. Gregor Verhoef, Ph.D.; Noppadol Siritanaratkul; Evgenii Osmanov; Julia Alexeeva; Juliana Pereira, PhD; prof. MUDr. Jiří Mayer, CSc.; Xiaonan Hong; Yoshiharu Maeda; Lixia Pei, PhD; Brendan Rooney, PhD; MD Helgi van de Velde, PhD; Prof. MD Franco Cavalli, FRCP
Číslo abstraktu: 4412
Kategorie: Maligní lymfomy a leukémie

The Outcome of Mantle Cell Lymphoma patients after Treatment Failure and Prognostic value of Secondary Mantle Cell International Prognostic Index (sec MIPI)

Autoři: Prof. MUDr. Marek Trněný, CSc.; prof. MUDr. Pavel Klener, DrSc.; MUDr. David Belada, Ph.D.; MUDr. Heidi Móciková, Ph.D.; MUDr. Vít Procházka, Ph.D.; prof. MUDr. Samuel Vokurka, Ph.D.; MUDr. Jan Pirnos; MUDr. Kateřina Kubáčková; MUDr. Juraj Ďuraš; MUDr. Jana Šálková, CSc.; MUDr. David Šálek, Ph.D.; MUDr. Robert Pytlík, Ph.D.; MUDr. Lucie Barsová; MUDr. Petr Kessler; Doc. MUDr. Ludmila Boudová, Ph.D.; MUDr. Vít Campr, Ph.D.; MUDr. Radek Jakša; Jitka Dlouhá; MUDr. Kateřina Benešová, CSc.
Číslo abstraktu: 4425
Kategorie: Mnohočetný myelom

624. Lymphoma: Therapy with Biologic Agents, excluding Pre-Clinical Models: Aggressive NHL

Phase II Randomized, Multicenter Study of Lenalidomide Vs Best Investigator’s Choice in Relapsed/Refractory Mantle Cell Lymphoma: Results of the MCL-002 (SPRINT) Study

Autoři: Prof. MUDr. Marek Trněný, CSc.; MD Thierry Lamy; MD Jan Andrzej Walewski, Ph.D.; Wojciech Jurczak; MUDr. David Belada, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; Prof. M.D. John Radford; Julia Alexeeva; Evgenii Osmanov; Tsvetan Nikolov Biyukov; Meera Patturajan; Marie-Laure Casadebaig Bravo; Luca Arcaini
Číslo abstraktu: 626
Kategorie: Maligní lymfomy a leukémie

625. Lymphoma: Pre-Clinical – Chemotherapy and Biologic Agents II

Immunomodulatory Agent Lenalidomide Enhances Antitumor Functions of Chimeric Receptor-Modified T Cells in Vitro and in Vivo

Autoři: MUDr. Pavel Otáhal, PhD; Ing. Dana Průková; Vlastimil Král, PhD; MUDr. Radek Jakša; MUDr. Lucie Latečková; M.D. Petra Vočková; Barbora Svobodová, PhD; Prof. MUDr. Marek Trněný, CSc.; MUDr. Pavel Klener jr, Ph.D.
Číslo abstraktu: 805
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Outcomes With TKI Therapy

Interim Analysis of a Pan European Stop Tyrosine Kinase Inhibitor Trial in Chronic Myeloid Leukemia : The EURO-SKI study

Autoři: M.D. Francois-Xavier Mahon, Ph.D.; M.D. Johan Richter, Ph.D.; Joelle Guilhot (Guillhot), PhD; Prof. Dr. med. Martin C. Müller; Dr. Christian Dietz, Ph.D.; MD Kimmo Porkka, PhD; M.D. Henrik Hjort-Hansen, Ph.D.; M.D. Franz Gruber; MD Panos Panagoitidis; MD Gert (J.) Ossenkoppele, PhD; prof. MUDr. Jiří Mayer, CSc.; MD Antonio Medina Almeida, PhD; Mgr. Kateřina Machová (Poláková), Ph.D.; Prof. M.D. Hans Ehrencrona, Ph.D.; MD Veli Kairisto, PhD; MD Marc C. Berger, PhD; MD Ulla Olsson Stromberg; MD Satu Mustjoki, PhD; MD Andreas Hochhaus; Dr. rer. biol. hum. Markus Pfirrmann, M.Sc.; MD Susanne Saussele
Číslo abstraktu: 151
Kategorie: Maligní lymfomy a leukémie

Final Study Results of the Phase 3 Dasatinib Versus Imatinib in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Trial (DASISION, CA180-056)

Autoři: M.D. Jorge E. Cortes; MD Giuseppe Saglio, PhD.; MD Michele Baccarani; M.D. Hagop M. Kantarjian; prof. MUDr. Jiří Mayer, CSc.; MD Concepción Boqué; MD Neil Shah, PhD; MD Charles Chuah; MD Luis Casanova; MD Geetha Narayanan, DM; M.D. M. Brigid Bradley-Garelik; George Manos, PhD; MD Andreas Hochhaus
Číslo abstraktu: 152
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Prognosis and Therapy

The Experience of the International Registry for Chronic Myeloid Leukemia (CML) in Children and Adolescents (I-CML-Ped Study): Pronostic Consideration

Autoři: Frédéric Millot; Joelle Guilhot (Guillhot), PhD; Prof. MD Meinolf Suttorp, PhD; prof. MUDr. Petr Sedláček, CSc.; MD Eveline S.J.M. de Bont, PhD; MD Chi Kong Li, MBBS; Krzysztof Kalwak; Birgitte Lausen; Srdjana Culic; Marie-Françoise Dresse; MD Andrea Biondi; MD Andre Baruchel, PhD
Číslo abstraktu: 521
Kategorie: Epidemiologie nádorů a Národní onkologický registr ČR; Maligní lymfomy a leukémie

Impairment of Longitudinal Growth By Tyrosine Kinase Inhibitor (TKI) Treatment - Data from a Large Pediatric Cohort with Chronic Myeloid Leukemia (CML)

Autoři: Josephine Tabea Tauer, PhD; Christina Nowasz; prof. MUDr. Petr Sedláček, CSc.; MD Eveline S.J.M. de Bont, PhD; Prof. M.D. Olga Aleinikova; Prof. MD Meinolf Suttorp, PhD
Číslo abstraktu: 522
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Poster

Comparison of Glucose and Lipid Metabolism Abnormality during Nilotinib, Imatinib and Dasatinib Therapy – Results of Enigma 2 Study

Autoři: Prof. MUDr. Zdeněk Ráčil, Ph.D.; MUDr. Petra Bělohlávková; prof. MUDr. Petr Cetkovský, Ph.D.; prof. MUDr. Edgar Faber, CSc.; MUDr. Hana Klamová, CSc.; RNDr. Ludmila Malášková; MD Tomasz Sacha; MUDr. Jaroslava Voglová; MUDr. Daniela Žáčková, Ph.D.; Prof. MUDr. Pavel Žák, Ph.D.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 1813
Kategorie: Maligní lymfomy a leukémie

Impact of Additional Cytogenetic Abnormalities and Variant t(9;22) at Diagnosis on Prognosis of Childhood Chronic Myelogenous Leukemia : The Experience of the International Registry for CML in Children and Adolescents (I-CML-Ped Study)

Autoři: Frédéric Millot; Joelle Guilhot (Guillhot), PhD; Prof. MD Meinolf Suttorp, PhD; prof. MUDr. Petr Sedláček, CSc.; MD Eveline S.J.M. de Bont, PhD; MD Chi Kong Li, MBBS; Krzysztof Kalwak; Birgitte Lausen; Srdjana Culic; Marie-Françoise Dresse; MD Andrea Biondi; MD Andre Baruchel, PhD; MD Françoise Brizard
Číslo abstraktu: 3137
Kategorie: Maligní lymfomy a leukémie

Incidence of CML in Europe - a Comparison of 19 European Countries with US SEER Data

Autoři: Dr. rer. biol. hum. Verena Sophia Hoffmann, BSc, M.A.; Dipl. Inf. Doris Lindörfer (Lindoerfer); Dr. Josef Thaler, Ph.D.; Boris Labar, MD, PhD; prof. MUDr. Jiří Mayer, CSc.; Prof. M.D. Hele Everaus (1953-), Ph.D.; Joelle Guilhot (Guillhot), PhD; Dr. Frederiki Melanthiou; Dr.rer.biol.hum Gabriele Schubert-Fritschle; MD Fausto Castagnetti; M.D. Sandra Lejniece, Ph.D.; M.D. Laimonas Griskevicius (Griškevičius); M.D. Noortje Thielen; MD Tomasz Sacha; MD Andrzej Hellmann, Ph.D.; MD Anna Turkina, PhD; MD Andrey Zaritsky (Zaritskey); Andrija Bogdanovic; prof. MUDr. Karel Indrák, DrSc.; M.D. Irena Zupan, Ph.D.; MD Juan Luis Steegmann, PhD; MD Bengt Simonsson, PhD; Dr. Richard E. Clark, MBBS, MD, FRCP, FRCPath; M.D. Martin Hoglund, Ph.D.; Prof. Dr. Rüdiger Hehlmann; MD Joerg Hasford; MD Michele Baccarani
Číslo abstraktu: 3145
Kategorie: Maligní lymfomy a leukémie

Baseline Characteristics of CML Patients Accross Europe - Comparing Real-World Patients with Patient Collectives Included in Clinical Trials

Autoři: MD Michele Baccarani; Dr. rer. biol. hum. Verena Sophia Hoffmann, BSc, M.A.; Prof. MD Gianantonio Rosti; MD Fausto Castagnetti; MD Susanne Saussele; Joelle Guilhot (Guillhot), PhD; MD Bengt Simonsson, PhD; MD Juan Luis Steegmann, PhD; prof. MUDr. Jiří Mayer, CSc.; prof. MUDr. Karel Indrák, DrSc.; MD Anna Turkina, PhD; MD Andrey Zaritsky (Zaritskey); Boris Labar, MD, PhD; M.D. Irena Zupan, Ph.D.; M.D. Noortje Thielen; Dr. Richard E. Clark, MBBS, MD, FRCP, FRCPath; Dr. Josef Thaler, Ph.D.; Dr. Frederiki Melanthiou; Prof. M.D. Hele Everaus (1953-), Ph.D.; MD Kimmo Porkka, PhD; Andrija Bogdanovic; Dr.rer.biol.hum Gabriele Schubert-Fritschle; M.D. Panagiotis Panagiotidis; MD Tamas Masszi, PhD; M.D. Sandra Lejniece, Ph.D.; M.D. Laimonas Griskevicius (Griškevičius); MD Andrzej Hellmann, Ph.D.; dr n. med Witold Prejzner; MD Tomasz Sacha; MD Antonio Medina Almeida, PhD; Dr. Irina Dyagil; Dr. Adriana Colita; Prof. M.D. Georgi Mihaylov, Ph.D.; Prof. Dr. Rüdiger Hehlmann; MD Joerg Hasford; Dipl. Inf. Doris Lindörfer (Lindoerfer)
Číslo abstraktu: 3160
Kategorie: Maligní lymfomy a leukémie

The Observed and Expected Incidence of Cardiovascular (CV) Ischemic Events in Dasatinib (DAS)-Treated Patients (pts) Across a Clinical Trial Program

Autoři: MD Giuseppe Saglio, PhD.; Philipp le Coutre; M.D. Jorge E. Cortes; prof. MUDr. Jiří Mayer, CSc.; M.D. Philip Rowlings; M.D. Francois-Xavier Mahon, Ph.D.; MD Glenn S. Kroog; Kyna Gooden, PhD, MPH; MD Milayna Subar; M.D. Jeanette Preston, MPH; MD Neil Shah, PhD
Číslo abstraktu: 4534
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: TKI cessation, monitoring and resistance

In Chronic Myeloid Leukemia Patients on 2nd-Line Tyrosine Kinase Inhibitor Therapy, Deep Sequencing at the Time of Warning May Allow Sensitive Detection of Emerging BCR-ABL1 Mutants

Autoři: Simona Soverini; Caterina De Benedittis; Luca Zazzeroni; Mgr. Kateřina Machová (Poláková), Ph.D.; MD Fausto Castagnetti; Gabriele Gugliotta; Maria Teresa Bochicchio; Ilaria Iacobucci, PhD; MD Marzia Salvucci; MD Monica Crugnola; MD Gianni Binotto; Massimiliano Bonifacio; MD Giovanna Leonardi; MD Alessandra Iurlo; MD Giorgina Specchia; Prof. Domenico Russo; MD Fabrizio Pane; MD Giuseppe Saglio, PhD.; Prof. MD Gianantonio Rosti; MD Michele Cavo; MD Michele Baccarani; Prof.MD Giovanni Martinelli
Číslo abstraktu: 815
Kategorie: Maligní lymfomy a leukémie

634. Myeloproliferative Syndromes: Clinical: Poster II

Switch from Every Two Weeks to Every Four Weeks Administration Schedule of AOP2014, an Innovative Pegylated Interferon Alpha, in Polycythemia Very Patients Allows Maintaining of Efficacy with Improved Toxicity Profile in Phase I/II Study

Autoři: MD Heinz Gisslinger; MD Veronika Buxhofer-Ausch; Dr. Josef Thaler, Ph.D.; MD Ernst Schloegl (Schlögl); MD Günther Gastl; MD Dominik Wolf; Robert Kralovics, PhD; Bettina Gisslinger; MD Karin Strecker; Prof.MUDr. Alexander Egle; M.D. Thomas Melchardt; MD Sonja Burgstaller; MD Ella Willenbacher; Dr. Michael Zoerer (Zörer), PhD; Pavla Kadlecová, PhD; MD Oleh Zagrijtschuk; Christoph Klade, PhD; MD Richard Greil, Ph.D.
Číslo abstraktu: 3177
Kategorie: Myeloproliferativní nemoci

637. Myelodysplastic Syndromes – Clinical Studies: Molecular Characterization and Lower Risk MDS

Efficacy and Safety of Lenalidomide (LEN) Versus Placebo (PBO) in RBC-Transfusion Dependent (TD) Patients (Pts) with IPSS Low/Intermediate (Int-1)-Risk Myelodysplastic Syndromes (MDS) without Del(5q) and Unresponsive or Refractory to Erythropoiesis-Stimulating Agents (ESAs): Results from a Randomized Phase 3 Study (CC-5013-MDS-005)

Autoři: MD Valeria Santini; MD Antonio Medina Almeida, PhD; MD Aristoteles Giagounidis, PhD; MD Stephanie Gröpper; doc. MUDr. Anna Jonášová, Ph.D.; MD Norbert Vey, PhD; Ghulam J. Mufti, DM, FRCP, FRCPath; MD Rena Buckstein; M.D. Moshe Mittelman; MD Uwe Platzbecker; MD Ofer Shpilberg, MPH; MD Ron Ram; MD Consuelo del Canizo, PhD; MD Norbert Gattermann; MD Keiya Ozawa, PhD; Jim Zhong, PhD; Francis Séguy; MD Albert Hoenekopp; MD C.L. Beach; MD Pierre Fenaux, PhD
Číslo abstraktu: 409
Kategorie: Myelodysplastický syndrom

637. Myelodysplastic Syndromes – Clinical Studies: Poster

Bone Marrow Immunophenotyping By Flow Cytometry in Refractory Cytopenia of Childhood

Autoři: Anna M. Aalbers; MD Marry M. van den Heuvel-Eibrink, PhD; MD Irith Baumann; Prof. MD Michael Dworzak; Prof. MD Henrik Hasle; Prof. MD Franco Locatelli, PhD; MD Barbara De Moerloose; MD Markus Schmugge (Schmugge-Liner); MUDr. Ester Mejstříková, Ph.D.; MUDr. Michaela Nováková; MD Marco Zecca; MD Christian Michel Zwaan, PhD; Jeroen G. te Marvelde; Dr. Anton W. (Ton) Langerak ; MD Jacques J.M. van Dongen, PhD; Prof. MD Rob Pieters, PhD; Prof. MD Charlotte M. Niemeyer, PhD; Vincent H.J. Van der Velden, PhD
Číslo abstraktu: 1916
Kategorie: Myeloproliferativní nemoci; Nádory dětského a adolescentního věku

Hepcidin and GDF15 Levels during the First 2 Years Follow-up in Patients with Low and Int-1 Risk Myelodysplastic Syndromes (MDS) from the European Leukemianet MDS Registry

Autoři: MD Louise de Swart; Chloé Reiniers; Tim Bagguley; Corine van Marrewijk, PhD; MD David Bowen, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.; MD Eva Hellström-Lindberg; MD Aurelia Tatic; Dr. Argyris Symeonidis, Ph.D.; MD Gerwin A Huls, PhD; Alexandra Smith; MD Theo de Witte, PhD
Číslo abstraktu: 3267
Kategorie: Myelodysplastický syndrom

The Prognostic Significance of TP53

Autoři: Mgr. Monika Běličková; Mgr. Jitka Veselá; doc. MUDr. Anna Jonášová, Ph.D.; Ing. Eliška Stará (Čechová); Ing. Barbora Planetová; Doc.RNDr. Zuzana Zemanová, CSc.; RNDr. Jana Březinová, Ph.D.; MUDr. Dana Mikulenková; prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 4630
Kategorie: Myelodysplastický syndrom

641. CLL: Biology and Pathophysiology, excluding Therapy: Advances in (Immuno)genetics

Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-κB Deregulation in Aggressive Chronic Lymphocytic Leukemia

Autoři: Larry Mansouri; Lesley-Ann Sutton; Viktor Ljungström; Sina Bondza; Linda Arngarden; Sujata Bhoi; Jimmy Larsson; Diego Cortese; Antonia Kalushkova, PhD; Rebeqa Gunnarsson; Emma Young; Elin Falk-Sorqvist; Mgr. Karla Plevová, Ph.D.; Alice F. Muggen, PhD; M.D. Xiao-Jie Yan, Ph.D.; MD Birgitta Sander, Ph.D.; MD Gunilla Enblad, PhD; M.D. Karin Ekström Smedby, Ph.D.; Prof. MD Gunnar Juliusson, PhD; MD Chrysoula Belessi; MD Nicholas Chiorazzi; BSc. Jonathan C. Strefford, PhD; Dr. Anton W. (Ton) Langerak ; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Frederic Davi, PhD; Mats Hellstrom; Helena Jernberg Wiklund, Ph.D.; M.D. Paolo Ghia, Ph.D.; Ola Soderberg; MD Kostas Stamatopoulos; Mats Nilsson; Prof. MD Richard Rosenquist (Brandell), PhD
Číslo abstraktu: 297
Kategorie: Maligní lymfomy a leukémie

641. CLL: Biology and Pathophysiology, excluding Therapy: Poster

High-Throughput T-Cell Receptor Gene Repertoire Profiling in Chronic Lymphocytic Leukemia Reveals a Molecular Signature of Antigen Selection

Autoři: MD Anna Vardi, MSc.; Evangelia Stalika; Athanasios Gkoufas; Maria Karypidou; Vasilis Bikos; prof. RNDr. Šárka Pospíšilová, Ph.D.; Dr. Achilles Anagnostopoulos; Nikos Maglaveras, M.Sc., PH.D.; Anastasia Hadzidimitriou; Ioanna Chouvarda; MD Kostas Stamatopoulos
Číslo abstraktu: 1950
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Charting Unique Signatures of Somatic Hypermutation Amongst Chronic Lymphocytic Leukemia Patients Expressing IGHV4-34 Clonotypic B Cell Receptors

Autoři: Aliki Xochelli; Ioannis Kavakiotis; Andreas Agathangelidis; Prof. M.D. Dirk Kienle; Zadie Davis; M.D. Xiao-Jie Yan, Ph.D.; M.D. Tait D. Shanafelt; Myriam Boudjogra; Mgr. Karla Plevová, Ph.D.; Maria Chatzouli; Lone Bredo Pedersen; Silvio Veronese, ScD; Monica Facco; Denis Moreno; Charles Chiyuan Chu, Ph.D.; Veronique Giudicelli; M.D. Panagiotis Panagiotidis; Prof. Ioannis P. Vlahavas; Dr. Achilles Anagnostopoulos; Nikos Maglaveras, M.Sc., PH.D.; Dr. Livio Trentin; Dr. Mark Catherwood; MD Marco Montillo; MD Christian H. Geisler, PhD; Dr. Anton W. (Ton) Langerak ; prof. RNDr. Šárka Pospíšilová, Ph.D.; Prof. Marie-Paule Lefranc; MD Nicholas Chiorazzi; Prof. David Graham Oscier; Dr. Diane F. Jelinek, Ph.D.; MD Stephan Stilgenbauer; MD Chrysoula Belessi; M.D. Paolo Ghia, Ph.D.; MD Frederic Davi, PhD; Prof. MD Richard Rosenquist (Brandell), PhD; Dr. Nikos Darzentas, PhD; Ioanna Chouvarda; Lesley-Ann Sutton; Anastasia Hadzidimitriou; MD Kostas Stamatopoulos
Číslo abstraktu: 1969
Kategorie: Maligní lymfomy a leukémie

A Complementary Role of High Throughput Sequencing and Multiparameter Cytometry for Minimal Residual Disease (MRD) Detection in Chronic Lymphocytic Leukemia (CLL):an European Research Initiative (ERIC) Study

Autoři: Andy Rawstron, PhD; Claudia Fazi, PhD; M.D. Neus Villamor, Ph.D.; M.D. Julio Delgado, Ph.D.; Remi Letestu; M.D. Florence Cymbalista, Ph.D.; Carlos Palacio; MD Francesc Bosch, PhD; MSc. Ruth M. De Tute; Stuart Liptrot; David O'Brien, FAMLs; MUDr. Martin Špaček, Ph.D.; Johan Dobber; MD Arnon P. Kater, PhD; Peter C. Gambell; Dr. David A. Westerman, MBBS, FRACP, FRCPA; Asha Soosapilla; Stephen P. Mulligan, MBBS, PhD, FRACP, FRCPA; Dr. Gerard Lozanski; Dr. Ke Lin; Prof. Andrew R Pettitt, MRCP, PhD; Dr. Gabi Brachtl; Prof.MUDr. Alexander Egle; David W Williamson, PhD; Catherine M. Sanders, PhD; Harlan Robins, PhD; Justin Boysen; M.D. Tait D. Shanafelt; MD Curtis A. Hanson; MD Jeffrey L. Jorgensen, PhD; MD William G. Wierda, PhD; MD Constance Yuan, PhD; MD Maryalice Stetler-Stevenson, PhD; Laura Z. Rassenti, PhD; MD H. Elizabeth Broome; MD Thomas J. Kipps, PhD; Mathieu Hauwel; MUDr. Iuri Marinov, CSc.; MD Fiona E. Craig, MBBS; Josep F. Nomdedéu; M.D. Carol Moreno; Ing. Olga Stehliková; prof. MUDr. Michael Doubek, Ph.D.; prof. RNDr. Šárka Pospíšilová, Ph.D.; M.D. Karl-Anton Kreuzer; Prof. MD Michael Hallek; Peter Hillmen, M.B. ChB, Ph.D.; Prof. Dr. Emili Montserrat; M.D. Paolo Ghia, Ph.D.
Číslo abstraktu: 1976
Kategorie: Maligní lymfomy a leukémie

Clinical Impact of Stereotyped Antigen Receptors in Chronic Lymphocytic Leukemia

Autoři: Panagiotis Baliakas; Anastasia Hadzidimitriou; Lesley-Ann Sutton; Evangelia Minga; Andreas Agathangelidis; Athina Tsanousa, PhD; Lydia Scarfo; Zadie Davis; Joy Yan; M.D. Tait D. Shanafelt; Mgr. Karla Plevová, Ph.D.; MD Yorick Sandberg, PhD; Fie Juhl Vojdeman; Myriam Boudjogra; Tatiana Tzenou ; Maria Chatzouli; Charles Chiyuan Chu, Ph.D.; Silvio Veronese, ScD; Anne Gardiner; Larry Mansouri; M.D. Karin Ekström Smedby, Ph.D.; Lone Bredo Pedersen; Denis Moreno; Kirsten van Lom; Veronique Giudicelli; Mgr. Hana Skuhrová Francová; Florence Nguyen-Khac; M.D. Panagiotis Panagiotidis; Prof. MD Gunnar Juliusson, PhD; Prof. Lefteris Angelis; Dr. Achilles Anagnostopoulos; Prof. Marie-Paule Lefranc; Dr. Livio Trentin; Dr. Mark Catherwood; MD Marco Montillo; MD Christian H. Geisler, PhD; Dr. Anton W. (Ton) Langerak ; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Nicholas Chiorazzi; Prof. David Graham Oscier; Dr. Diane F. Jelinek, Ph.D.; Dr. Nikos Darzentas, PhD; MD Chrysoula Belessi; MD Frederic Davi, PhD; Prof. MD Richard Rosenquist (Brandell), PhD; M.D. Paolo Ghia, Ph.D.; MD Kostas Stamatopoulos
Číslo abstraktu: 3280
Kategorie: Maligní lymfomy a leukémie

Prognostic Impact of NOTCH1 Hotspot Mutation in TP53-Mutated Patients with Chronic Lymphocytic Leukemia

Autoři: Mgr. Barbara Kantorová; RNDr. Jitka Malčíková, Ph.D.; Mgr. Veronika Navrkalová, Ph.D.; prof. RNDr. Jana Šmardová, CSc.; Bc. Kamila Brázdilová; Mgr. Karla Plevová, Ph.D.; Mgr. Eva Divíšková; Mgr. Marek Borský; Mgr. Šárka Pavlová, PhD; Mgr. Nikola Tom; Mgr. Karol Pál; Doc. MUDr. Martin Trbušek, PhD; RNDr. Alexandra Oltová; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 3283
Kategorie: Maligní lymfomy a leukémie

Tracing the Ontogeny of IgG-Switched CLL: High-Throughput Immunogenetic Evidence

Autoři: MD Anna Vardi, MSc.; Evangelia Stalika; Maria Karypidou; Lesley-Ann Sutton; Vasilis Bikos; Dr. Achilles Anagnostopoulos; prof. RNDr. Šárka Pospíšilová, Ph.D.; Nikos Maglaveras, M.Sc., PH.D.; Prof. MD Richard Rosenquist (Brandell), PhD; MD Kostas Stamatopoulos; Ioanna Chouvarda; Anastasia Hadzidimitriou
Číslo abstraktu: 3285
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Subset-Specific Spectra of Recurrent Gene Mutations in Chronic Lymphocytic Leukemia with Stereotyped B-Cell Receptors

Autoři: Lesley-Ann Sutton; Emma Young; Panagiotis Baliakas; Anastasia Hadzidimitriou; Mgr. Karla Plevová, Ph.D.; M.D. Davide Rossi; RNDr. Jitka Malčíková, Ph.D.; Evangelia Stalika; Lone Bredo Pedersen; Andreas Agathangelidis; Zadie Davis; Larry Mansouri; Lydia Scarfo; Myriam Boudjogra; Alba Navarro (Lopez), Ph.D.; Alice F. Muggen, PhD; M.D. Xiao-Jie Yan, Ph.D.; M.D. Panagiotis Panagiotidis; MD Nicholas Chiorazzi; MD Christian H. Geisler, PhD; MD Chrysoula Belessi; M.D. Elias Campo, Ph.D.; BSc. Jonathan C. Strefford, PhD; M.D. Paolo Ghia, Ph.D.; Dr. Anton W. (Ton) Langerak ; Prof. David Graham Oscier; MD Gianluca Gaidano, PhD; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Frederic Davi, PhD; MD Kostas Stamatopoulos; Prof. MD Richard Rosenquist (Brandell), PhD
Číslo abstraktu: 3320
Kategorie: Maligní lymfomy a leukémie

642. CLL: Therapy, excluding Transplantation: Phase 3 Trials and More

Frontline Chemoimmunotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Shows Superior Efficacy in Comparison to Bendamustine (B) and Rituximab (BR) in Previously Untreated and Physically Fit Patients (pts) with Advanced Chronic Lymphocytic Leukemia (CLL): Final Analysis of an International, Randomized Study of the German CLL Study Group (GCLLSG) (CLL10 Study)

Autoři: MD Barbara Eichhorst; MD Anna-Maria Fink; Dipl.Math. Raymonde Busch, Ph.D.; Gabor Kovacs; Christian Maurer; M.D. Elisabeth Lange; Prof. Dr. Hubert Köppler; M.D. Michael Kiehl; M.D. Martin Soekler (Sökler); MD Rudolf Schlag; MD Ursula Vehling-Kaiser; M.D. Georg Köchling (Koechling); M.D. Christoph Plöger (Ploeger); M.D. Michael Gregor; MD Torben Plesner; Prof. MUDr. Marek Trněný, CSc.; M.D. Kirsten Fischer; Prof. Dr. med. Hartmut Döhner (Doehner); MD Michael Kneba, PhD; MD Clement Martin Wendtner; MD Wolfram Klapper, PhD; M.D. Karl-Anton Kreuzer; MD Stephan Stilgenbauer; MD Sebastian Böttcher; Prof. MD Michael Hallek
Číslo abstraktu: 19
Kategorie: Maligní lymfomy a leukémie

Rituximab Maintenance after Chemoimmunotherapy Induction in 1st and 2nd Line Improves Progression Free Survival: Planned Interim Analysis of the International Randomized AGMT-CLL8/a Mabtenance Trial

Autoři: MD Richard Greil, Ph.D.; MUDr. Petra Obrtlíková, Ph.D.; MUDr. Lukáš Smolej, Ph.D.; doc. MUDr. Tomáš Kozák, Ph.D., MBA; MD Michael Steurer; MD Johannes Andel; Dr. Josef Thaler, Ph.D.; MUDr. Eva Mikušková; M.D. Liana Gercheva; M.D. Thomas Nösslinger; MUDr. Miriam Ladická; M.D. Michael Girschikofsky; Prof. MUDr. Mikuláš Hrubiško, Ph.D.; M.D. Ulrich Jäger; Prim. Univ. Doz. Dr. Michael Fridrik; M.D. Martin Pecherstotfer; prof. MUDr. Eva Králíková, CSc.; M.D. Cristina Burcoveanu; M.D. Stefan Goranov; MUDr. Jana Jurkovičová; M.D. Andreas L. Petzer; Prof. M.D. Georgi Mihaylov, Ph.D.; MD Julian Ivanov Raynov, PhD
Číslo abstraktu: 20
Kategorie: Maligní lymfomy a leukémie

Ofatumumab (OFA) Maintenance Prolongs PFS in Relapsed CLL: Prolong Study Interim Analysis Results

Autoři: MD Marinus H.J. Van Oers, PhD; Prof. M.D. Kazimierz Kuliczkowski, PhD; MUDr. Lukáš Smolej, Ph.D.; Mario Petrini; MD Fritz C. Offner, PhD; Sebastian Gorsicki; Mark-David Levin; MD Ira (V.) Gupta; Jennifer Phillips; Vanessa Williams; MD Steen Lisby, DMSc; MD Christian H. Geisler, PhD
Číslo abstraktu: 21
Kategorie: Maligní lymfomy a leukémie

642. CLL: Therapy, excluding Transplantation: Poster

Gene Mutations and Treatment Outcome in CLL Patients Treated

Autoři: Dr. Eugen Tausch; Christina Galler; M.D. Richard F. Schlenk; Peter Hillmen, M.B. ChB, Ph.D.; MD Fritz C. Offner, PhD; MD Ann Janssens; Dr. K. Govind Babu, D.M.; prof. MUDr. Jiří Mayer, CSc.; M.D. Sebastian Grosicki; M.D. Panagiotis Panagiotidis; Daniel Mertens, PhD; Astrid McKeown, Ph.D.; MD Ira (V.) Gupta; Prof. Dr. med. Hartmut Döhner (Doehner); MD Stephan Stilgenbauer
Číslo abstraktu: 1992
Kategorie: Maligní lymfomy a leukémie

Low-Dose FCR Is a Safe and Effective Treatment Option for Elderly/Comorbid Patients with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Updated Results of Project Q-Lite By Czech CLL Study Group

Autoři: MUDr. Lukáš Smolej, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Eduard Cmunt, CSc.; MUDr. Martin Špaček, Ph.D.; MUDr. David Belada, Ph.D.; MUDr. Monika Motyčková; MUDr. Irena Zygulová; MUDr. Dagmar Adamová; MUDr. Vít Procházka, Ph.D.; MUDr. Martin Šimkovič; Ing. Kateřina Klásková; doc. MUDr. Tomáš Kozák, Ph.D., MBA
Číslo abstraktu: 4670
Kategorie: Maligní lymfomy a leukémie

651. Myeloma: Biology and Pathophysiology, excluding Therapy: Genomics

Exome Sequencing to Define a Genetic Signature of Plasma Cells in Systemic AL Amyloidosis

Autoři: MD Eileen Boyle; Dr. Brian A. Walker, Ph.D.; Dorota Rowczienio, MSc; Christopher P. Wardell, Ph.D.; Alexander Murison, Ph.D.; Mgr. Aneta Mikulášová; Sajitha Sachchithanantham, BSc, MBBS, MRCP, FRCPath; Anna Baginska; Shameem Mahmood, MRCP. FRCPath; Julian D Gillmore; MD Helen J Lachmann, FRCP; MD Philip N Hawkins, FRCP, FMedSci; MD Xavier Leleu, PhD; MD Faith E. Davies; Prof. M.D. Gareth J. Morgan, FRCP, FRCPath, Ph.D.; MD Ashutosh Wechalekar, FRCPath
Číslo abstraktu: 726
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

651. Myeloma: Biology and Pathophysiology, excluding Therapy: Mutational Landscape and Transcriptome Editing: Prognostic and Predictive Impact in Myeloma

Mutational Patterns and Copy Number Changes at Diagnosis Are a Powerful Tool to Predict Outcome: Result of the Sequencing Study of 463 Newly Diagnosed Myeloma Trial Patients

Autoři: MD Eileen Boyle; Dr. Brian A. Walker, Ph.D.; Christopher P. Wardell, Ph.D.; Alexander Murison, Ph.D.; Lorenzo Melchor, PhD; M.D. Martin F Kaiser; Dil Begum, BSc; Paula Proszek, MSc; Nasrin Dahir, BSc; David C Johnson, PhD; Charlotte Pawlyn, MBBChir; MD John Jones; Fabio Mirabella, Ph.D.; Dr. Annamaria Brioli; Mgr. Aneta Mikulášová; David A Cairns, PhD; Walter Gregory, PhD; Ana Quartilho, PhD; MD Mark Drayson, PhD; Prof. MD Nigel H. Russell; MD Gordon Cook, PhD; MD Graham H Jackson, PhD; MD Faith E. Davies; Prof. M.D. Gareth J. Morgan, FRCP, FRCPath, Ph.D.
Číslo abstraktu: 637
Kategorie: Mnohočetný myelom

651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster

Circulating Mir-130a in Multiple Myeloma and Extramedullary Myeloma Patients

Autoři: Mgr. Lenka Bešše (Kubiczková); Mgr. Lenka Sedlaříková; MUDr. Fedor Kryukov; Mgr. Lenka Radová, Ph.D.; RNDr. Jana Nekvindová, PhD; Mgr. Pavel Němec; Daniela Drandi; Simona Caltagirone; Paola Omede; Prof. MUDr. Marta Krejčí, Ph.D.; prof. MUDr. Zdeněk Adam, CSc.; prof. MUDr. Luděk Pour, Ph.D.; doc. RNDr. Sabina Ševčíková, Ph.D.; MD Antonio P. Palumbo; MD Mario Boccadoro; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 2043
Kategorie: Mnohočetný myelom

Impact of Novel Agents on Young Patients with t(11;14) Multiple Myeloma

Autoři: MD Jonas Paludo; Nishanth Vallumsetla, MBBS; M.D. Shaji Kumar; Rhett P. Ketterling; M.D. Morie Gertz, MACP; M.D. Angela Dispenzieri; M.D. Martha Q. Lacy; M.D. Francis K. Buadi; M.D. David Dingli, Ph.D.; MUDr. Utkarsh Painuly; M.D. Nelson Leung; M.D. Robert A. Kyle, MACP; Prof. Dr. S. Vincent Rajkumar; M.D. Prashant Kapoor
Číslo abstraktu: 2059
Kategorie: Mnohočetný myelom

Prediction of Progression of Smouldering into Therapy Requiring Multiple Myeloma By Easily Accessible Clinical Factors [in 527 Patients]

Autoři: prof. MUDr. Roman Hájek, CSc.; MUDr. Viera Sandecká, Ph.D.; MD Anja Seckinger, Ph.D.; Prof.MUDr. Ivan Špička, PhD; Prof.MUDr. Vlastimil Ščudla, CSc.; MUDr. Evžen Gregora; MUDr. Jakub Radocha; Bc. Lucie Brožová; RNDr. Jiří Jarkovský, Ph.D.; Mgr. Lucie Říhová, PhD.; Mgr. Aneta Mikulášová; MUDr. David Starostka; MUDr. Lenka Walterová; MUDr. Dagmar Adamová; MUDr. Petr Kessler; MUDr. Martin Brejcha; MD Ivan Vonke; MUDr. Jarmila Obernauerová; MUDr. Kamila Valentová; prof. MUDr. Zdeněk Adam, CSc.; MUDr. Jiří Minařík, Ph.D. ; MUDr. Jan Straub; MUDr. Jaromír Gumulec; Prof.MD Anthony D. Ho, PhD, FRCP; Jens Hillengass; Prof. Dr. med. Hartmut Goldschmidt; Doc. MUDr. Vladimír Maisnar, Ph.D.; MD Dirk Hose
Číslo abstraktu: 2071
Kategorie: Mnohočetný myelom

Somatic Mutation Spectrum in Monoclonal Gammopathy of Undetermined Significance Compared to Multiple Myeloma

Autoři: Mgr. Aneta Mikulášová; Dr. Brian A. Walker, Ph.D.; Christopher P. Wardell, Ph.D.; MD Eileen Boyle; Alexander Murison, Ph.D.; Mgr. Zuzana Kufová; prof. MUDr. Luděk Pour, Ph.D.; Prof.RNDr. Petr Kuglík, CSc.; prof. MUDr. Roman Hájek, CSc.; Prof. M.D. Gareth J. Morgan, FRCP, FRCPath, Ph.D.
Číslo abstraktu: 3346
Kategorie: Mnohočetný myelom

Evaluation of Current Clinical Models for Risk of Progression from Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma or Related Malignancies in 2028 Persons Followed in the Czech Republic

Autoři: MUDr. Viera Sandecká, Ph.D.; prof. MUDr. Zdeněk Adam, CSc.; Prof.MUDr. Ivan Špička, PhD; Prof.MUDr. Vlastimil Ščudla, CSc.; MUDr. Evžen Gregora; Doc. MUDr. Vladimír Maisnar, Ph.D.; Bc. Lucie Brožová; RNDr. Jiří Jarkovský, Ph.D.; Mgr. Lucie Říhová, PhD.; Mgr. Aneta Mikulášová; MUDr. David Starostka; MUDr. Lenka Walterová; MUDr. Dagmar Adamová; MUDr. Petr Kessler; MUDr. Martin Brejcha; MD Ivan Vonke; MUDr. Jarmila Obernauerová; MUDr. Kamila Valentová; prof. MUDr. Luděk Pour, Ph.D.; MUDr. Jiří Minařík, Ph.D. ; MUDr. Jan Straub; MUDr. Jakub Radocha; MUDr. Jaromír Gumulec; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 3376
Kategorie: Mnohočetný myelom

Cell-Free DNA for Minimal Residual Disease Monitoring in Multiple Myeloma Patients

Autoři: Mgr. Lenka Bešše (Kubiczková); Daniela Drandi; Mgr. Lenka Sedlaříková; Stefania Oliva; Manuela Gambella; Paola Omede; prof. MUDr. Zdeněk Adam, CSc.; prof. MUDr. Luděk Pour, Ph.D.; doc. RNDr. Sabina Ševčíková, Ph.D.; MD Mario Boccadoro; MD Antonio P. Palumbo; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 3423
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation I

A Randomized Phase III Trial of Melphalan and Dexamethasone (MDex) Versus Bortezomib, Melphalan and Dexamethasone (BMDex) for Untreated Patients with AL Amyloidosis

Autoři: MD Efstathios Kastritis; MD Xavier Leleu, PhD; Bertrand Arnulf; MD Elena Zamagni; Peter Mollee; M Teresa Cibeira; Stefan O. Schönland; Prof. MD Philippe Moreau; prof. MUDr. Roman Hájek, CSc.; MD Arnaud Jaccard; MD Emmanuelle Nicolas-Virelizier; Robin Filshie, PhD, FRACP; Bradley Augustson, MBBS, FRACP, FRCPA; MD Maria-Victoria Mateos, PhD; MD PaoloD Milani; Meletios Athanasios Dimopoulos, MD; MD Eric Hachulla, PhD; MD Jean-Pau Fermand, PhD; MD Andrea Foli; MD Antonio P. Palumbo; MD Pieter Sonneveld, PhD.; Prof. Hans Erik Johnsen; MD Giampaolo Merlini; MD Giovanni Palladini, PhD
Číslo abstraktu: 35
Kategorie: Maligní lymfomy a leukémie

653. Myeloma: Therapy, excluding Transplantation II

Carfilzomib, Lenalidomide, and Dexamethasone vs Lenalidomide and Dexamethasone in Patients (Pts) with Relapsed Multiple Myeloma: Interim Results from ASPIRE, a Randomized, Open-Label, Multicenter Phase 3 Study

Autoři: MD A. Keith Stewart; Prof. Dr. S. Vincent Rajkumar; Meletios Athanasios Dimopoulos, MD; MD Tamas Masszi, PhD; Prof.MUDr. Ivan Špička, PhD; M.D. Albert Oriol; prof. MUDr. Roman Hájek, CSc.; MD Laura Rosiñol, PhD; MD David Samuel diCapua Siegel, PhD; Prof. M.D. Georgi Mihaylov, Ph.D.; MD Vesselina Goranova-Marinova, PhD; MD Péter Rajnics, Ph.D.; M.D. Alexander Suvorov; MD Ruben Niesvizky; MD Andrzej Jakubowiak, PhD; Prof. M.D. Jesús San Miguel, Ph.D.; Prof. MD Heinz Ludwig; MD Naseem Zojwalla; PharmD. Margaret E. Tonda; Biao Xing, PhD; Prof. MD Philippe Moreau; MD Antonio P. Palumbo
Číslo abstraktu: 79
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Poster

Doublet Vs Triplet Lenalidomide-Containing Regimens in Newly Diagnosed Myeloma Patients, Younger or Older Than 75 Years: Subgroup Analysis of a Phase III Study

Autoři: MD Valeria Magarotto; MD Sara Bringhen; MD Pellegrino Musto; M.D. Massimo Offidani; Prof. MD Anna Marina Liberati; prof. MUDr. Luděk Pour, Ph.D.; Giulia Benevolo; M.D. Mariella Genuardi; prof. M.D. Caterina Musolino; Antonio Ledda; Daniela Oddolo, Ph.D.; MD Lorenzo De Paoli; Francesca Patriarca; M.D. Antonietta Pia Falcone; Isola Caratozzolo; Renato Zambello; Maide Cavalli; Silvia Gentili; prof. MUDr. Roman Hájek, CSc.; MD Mario Boccadoro; MD Antonio P. Palumbo
Číslo abstraktu: 2110
Kategorie: Mnohočetný myelom

Subcutaneous and Intravenous Bortezomib in Multiple Myeloma Patients Has Similar Response Rates and Toxicity Profile with No Difference in the Incidence of Peripheral Neuropathy: Report of the Czech Myeloma Group

Autoři: MUDr. Jiří Minařík, Ph.D. ; MUDr. Petr Pavlíček; prof. MUDr. Luděk Pour, Ph.D.; MUDr. Tomáš Pika; Doc. MUDr. Vladimír Maisnar, Ph.D.; Prof.MUDr. Ivan Špička, PhD; RNDr. Jiří Jarkovský, Ph.D.; Prof. MUDr. Marta Krejčí, Ph.D.; Doc.MUDr. Jaroslav Bačovský, CSc.; MUDr. Jakub Radocha; MUDr. Jan Straub; MUDr. Petr Kessler; MUDr. Marek Wróbel; MUDr. Lenka Walterová; MUDr. Michal Sýkora; MUDr. Jarmila Obernauerová; MUDr. Evžen Gregora; MUDr. Dagmar Adamová; MUDr. Jaromír Gumulec; prof. MUDr. Zdeněk Adam, CSc.; Prof.MUDr. Vlastimil Ščudla, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 2117
Kategorie: Mnohočetný myelom

Final Overall Survival Results of a Randomized Trial Comparing Bortezomib Plus Pegylated Liposomal Doxorubicin with Bortezomib Alone in Subjects with Relapsed or Refractory Multiple Myeloma

Autoři: M.D. Robert Z. Orlowski, Ph.D., M.P.H.; MD Arnon Nagler, MSc.; MD Pieter Sonneveld, PhD.; Prof. Dr. Joan Bladé, PhD; prof. MUDr. Roman Hájek, CSc.; MD Andrew Spencer; MD Tadeusz Robak, PhD.; Anna Dmoszynska; Noemi Horvath, MB, ChB, FRACP, FRCPA; Prof.MUDr. Ivan Špička, PhD; MD Heather J. Sutherland, PhD, FRACP; M.D. Alexander Suvorov; Liang Xiu; Trilok V. Parekh, PhD; Prof. M.D. Jesús San Miguel, Ph.D.
Číslo abstraktu: 3448
Kategorie: Mnohočetný myelom

Lenalidomide and Dexamethasone for Acute Light Chain-Induced Renal Failure: Final Results of a Phase II Study

Autoři: Prof. MD Heinz Ludwig; Elisabeth Rauch; Dr. Thomas Kuehr (Kühr); prof. MUDr. Zdeněk Adam, CSc.; Dr. Adalbert Weissmann (Weißmann); MD Hedwig Kasparu; MD Eva-Maria Autzinger; Daniel Heintel; MD Richard Greil, Ph.D.; M.D. Wolfram Poenisch; Dr. Niklas Zojer; MD Ercan Müldür
Číslo abstraktu: 3484
Kategorie: Mnohočetný myelom

The Combination of Frailty and ISS Scores Identifies a Simple Prognostic Index for Overall Survival in Elderly Patients Treated with Novel Agents-Based Induction Therapy

Autoři: MD Alessandra Larocca; MD Sara Bringhen; prof. MUDr. Roman Hájek, CSc.; MD Maria Teresa Petrucci; M.D. Massimo Offidani; Roberto Mina; MD Vittorio Montefusco; Gabriele Aitoro; Claudia Cellini; MD Enrico Maria Pogliani; MD Lorenzo De Paoli; Marina Ruggeri; MD Laura Maracci; MD Oreste Villani; Chiara (Clara) Nozzoli; M.D. Alessia La Fauci; MD Marta Chisini; Francesca Gay; M.D. Roberto Marasca; MD Stelvio Ballanti; Prof. M.D. Nicola Giuliani; MD Pellegrino Musto; MD Mario Boccadoro; MD Pieter Sonneveld, PhD.; MD Antonio P. Palumbo
Číslo abstraktu: 4740
Kategorie: Mnohočetný myelom

711. Cell Collection and Processing: Poster III

Non Interventional Prospective Clinical Study on Peripheral Blood Stem Cell Mobilization in Patients with Relapsed Lymphomas

Autoři: Gwendolyn van Gorkom; Herve Finel; Sebastian Giebel; David Pohlreich; Avichai Shimoni; MD Mark Ringhoffer; Gulsan Ayhan Sucak; Nicolaas PM Schaap; Prof. Dr.med. Peter Dreger; Anna Sureda, MD; MD Harry C. Schouten, PhD
Číslo abstraktu: 3852
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment and Acute Transplant Toxicities: Novel Conditioning Regimens

RIC Allo-SCT with Flu/Bu in Comparison to Flu/Mel for AML Results in Similar Overall Survival: A Report from the ALWP of the EBMT

Autoři: MD Frederic Baron, PhD; MD Myriam Labopin, MS; MD Andrew Peniket; MUDr. Pavel Jindra, Ph.D.; Boris Afanasyev; MD Miguel A. Sanz, PhD; M.D. Eric Deconinck, Ph.D.; MD Arnon Nagler, MSc.; MD Mohamad Mohty, PhD
Číslo abstraktu: 545
Kategorie: Maligní lymfomy a leukémie

Myeloablative Chemo-Conditioning for First Hematopoietic STEM CELL Transplantation in Children with ACUTE Lymphoblastic Leukemia in First or Second Remission

Autoři: MD Christina Peters, Ph.D.; M.D. Jean-Hugues Dalle, Ph.D.; Prof. MD Stelios Graphakos; prof. MUDr. Petr Sedláček, CSc.; MD Antonio Campos; Prof. MD M. Akif Yesilipek; M.D. Jacek Wachowiak, Ph.D.; MD Arjan Lankester, PhD; Prof. MD Andrea Pession; M.D. Amir Ali Hamidieh; MD Marianne Ifversen, PhD; MD Jochen Büchner, PhD; MD Gergely Krivan, PhD; M.D. Franca Fagioli; Arnaud Dalissier; MD Myriam Labopin, MS; Peter Bader
Číslo abstraktu: 546
Kategorie: Maligní lymfomy a leukémie; Nádory dětského a adolescentního věku

721. Clinical Allogeneic Transplantation: Conditioning Regimens, Engraftment and Acute Transplant Toxicities: Personalizing Transplant Outcomes

Genetic Determinants of Busulfan Clearance and Outcomes in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation- Result of a Multicentric Prospective Study on Behalf of the Pediatric Disease Working Party of the European Blood and Marrow Transplantation Group

Autoři: MD Marc Ansari; M A Rezgui; Chakradhara Rao S Uppugunduri; Yves Théoret; Yves Chalandon; LL Dupuis; MD Tal Schechter; IH Bartelink; M.D. Jaap Jan Boelens, Ph.D.; M.D. Jean-Hugues Dalle, Ph.D.; Saba Azarnoush; prof. MUDr. Petr Sedláček, CSc.; MD Victor A. Lewis; S Mezziani; M-F Vachon; MD Michel Duval; MD Martin A. Champagne, FRCPC; MD Christina Peters, Ph.D.; MD Henrique Bittencourt; Maja Krajinovic
Číslo abstraktu: 424
Kategorie: Maligní lymfomy a leukémie

731. Clinical Autologous Transplantation: Results: Clinical Results in Plasma Cell Dyscrasias 2

Impact of Autologous Transplantation Vs. Chemotherapy Plus Lenalidomide in Newly Diagnosed Myeloma According to Patient Prognosis: Results of a Pooled Analysis of 2 Phase III Trials

Autoři: Francesca Gay; M.D. Chiara Cerrato; prof. MUDr. Roman Hájek, CSc.; M.D. Francesco Di Raimondo; MD Tommaso Caravita; M.D. Antonietta Pia Falcone; Francesca Patriarca; M.D. Stefano Pulini; M.D. Paola Finsinger; MD Giovannino Ciccone, PhD
Číslo abstraktu: 198
Kategorie: Maligní lymfomy a leukémie

731. Clinical Autologous Transplantation: Results: Poster I

Autologous Stem Cell Transplantation for Primary Mediastinal B Cell Lymphoma in the Rituximab Era: A Retrospective Study By the EBMT Lymphoma Working Party

Autoři: MD Irit Avivi; Ariane Boumendil, Ph.D.; Herve Finel; MD Arnon Nagler, MSc.; MD Aïda Sousa Bothello; MD Josep Maria Ribera Santasusana; Elisabeth A. Vandenberghe, MB, PhD; Boris Afanasyev; MD Dominique Bordessoule , PhD; MD José Maria Moraleda; MD Eulogio Conde, PhD; David Pohlreich; Prof. Dr.med. Peter Dreger
Číslo abstraktu: 1195
Kategorie: Maligní lymfomy a leukémie

731. Clinical Autologous Transplantation: Results: Poster II

High Dose Therapy and Autologous Stem Cell Transplantation in Marginal Zone Lymphoma : An EBMT-FIL-Gimeto Retrospective Study

Autoři: MD Irit Avivi; Luca Arcaini; MD Virginia Ferretti; Ariane Boumendil, Ph.D.; Herve Finel; Cristiana Pascutto, PhD; Dr. Giuseppe Milone; MD Francesco Zaja; MD Liliana Devizzi; MD Maurizio Musso; Prof. Dr. Didier Blaise; MD Gilles Andre Salles, PhD; MD Mohammed Wattad; MD Emmanuelle Nicolas-Virelizier; MD Martin Gramatzki; Prof. M.D. Jean-Henri Bourhis, Ph.D.; MD Denis Caillot; Shannon Haenel; Anette Haenel; MD Gerhard Held; M.D. Catherine Thieblemont, Ph.D.; MUDr. Pavel Jindra, Ph.D.; David Pohlreich; Joelle Guilhot (Guillhot), PhD; Prof. Dr. Martin Bornhaeuser (Bornhäuser); MD Per T. Ljungman; Prof. MD Christof Scheid, Ph.D.; MD Norbert Ifrah; Christian Berthou; Prof. Dr.med. Peter Dreger; MD Silvia Montoto; MD Annarita Conconi
Číslo abstraktu: 2526
Kategorie: Maligní lymfomy a leukémie

731. Clinical Autologous Transplantation: Results: Poster III

Allogeneic HCT with Reduced Intensity Conditioning Versus Autologous HCT for >55 Years Old Patients with Acute Lymphoblastic Leukemia in First Complete Remission: An Analysis from Acute Leukemia Working Party of the EBMT

Autoři: Sebastian Giebel; MD Myriam Labopin, MS; MD Norbet Claude Gorin; MD Noel-Jean Milpied, Ph.D.; MD Eefke J Petersen, PhD; MD Michael N Potter, PhD; MD Jan Cornelissen, PhD; MD Denis Caillot; MD Dietger W Niederwieser; Rovira Montserrat; MUDr. Pavel Jindra, Ph.D.; MD Ellen Meijer, PhD; M.D. Johan Maertens, Ph.D.; M.D. Alessandro Rambaldi; MD Arnon Nagler, MSc.; MD Mohamad Mohty, PhD
Číslo abstraktu: 3974
Kategorie: Maligní lymfomy a leukémie

732. Clinical Allogeneic Transplantation: Results: Poster I

Allogeneic Hematopoietic Cell Transplantation in AML with Normal Karyotype and NPM1 Mutated FLT3-ITD Negative: A Retrospective Analysis from the Acute Leukemia Working Party of EBMT

Autoři: Ali Bazarbachi; MD Myriam Labopin, MS; MD Mohamed A Kharfan-Dabaja; M.D. Rainer Schwerdtfeger; MD Liisa Volin, Ph.D.; Prof. M.D. Jean-Henri Bourhis, Ph.D.; MD Gerard Socié, Ph.D.; M.D. Eric Deconinck, Ph.D.; MD Tobias Gedde-Dahl, PhD; M.D. Alessandro Rambaldi; MUDr. Pavel Jindra, Ph.D.; M.D. Günther Schlimok; Prof. Dr. Didier Blaise; MD Patrice Chevallier, PhD; MD Arnon Nagler, MSc.; Dr. Christoph Schmid; MD Jordi Esteve, PhD; MD Mohamad Mohty, PhD
Číslo abstraktu: 1230
Kategorie: Maligní lymfomy a leukémie

732. Clinical Allogeneic Transplantation: Results: Poster II

Allogeneic Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndrome (MDS) Patients at Lower Risk According to International Prognostic Scoring System (IPSS) : A Retrospective Study on Behalf of the Cmwp of the EBMT

Autoři: M.D. Marie Robin, PhD; Raphael Porcher; Anja van Biezen; MD Liisa Volin, Ph.D.; Ghulam J. Mufti, DM, FRCP, FRCPath; Prof. MD Charles F. Craddock, BM, MRCP, MRCPath; Prof. Dr. med. Jürgen Finke; Carlos Richard Espiga; Prof. Dr. Jakob Passweg; MD Andrew Peniket; M.D. Johan Maertens, Ph.D.; M.D. Gülsan Türköz Sucak; MD Tobias Gedde-Dahl, PhD; MUDr. Antonín Vítek; MD Arnon Nagler, MSc.; Prof. Dr. Didier Blaise; M.D. Dietrich W. Beelen; MD Natacha Maillard; M.D. Rainer Schwerdtfeger; Simona Iacobelli, Ph.D.; MD Theo M. de Witte; MD Nicolaus Kröger
Číslo abstraktu: 2530
Kategorie: Myelodysplastický syndrom

Long-Term Follow-up Data Support the Curative Potential of Allogeneic Hematopoietic Cell Transplantation in Patients with Chronic Lymphocytic Leukemia: A Retrospective Analysis from the Chronic Malignancies Working Party of the EBMT

Autoři: Michel Van Gelder; Liesbeth C. de Wreede, Ph.D.; Anja Henseler, MSC; Anja van Biezen; MD Dietger W Niederwieser; MUDr. Michal Karas; MD Niels Smedegaard Andersen, PhD; MD Martin Gramatzki; Prof. Dr.med. Peter Dreger; MD Donald W. Bunjes, PhD; MD Eefke J Petersen, PhD; MD Michael N Potter, PhD; M.D. Dietrich W. Beelen; MD Ibrahim Yakoub-Agha, PhD; MD Jan Cornelissen, PhD; Prof. MD Nigel H. Russell; Prof. Dr. med. Jürgen Finke; MD Helene Schoemans; Prof. Dr. Didier Blaise; MD Paneesha Shankara; MUDr. Antonín Vítek; Prof. Dr. Martin Bornhaeuser (Bornhäuser); Stefan O. Schönland; MD Nicolaus Kröger; MD Johannes Schetelig, MSC
Číslo abstraktu: 2561
Kategorie: Maligní lymfomy a leukémie

802. Chemical Biology and Experimental Therapeutics: Poster I

Targeting C-Myc Promoter: Helquats As Novel G-Quadruplex Stabilizing

Autoři: Erika Kužmová, PhD; Jaroslav Kozák, MS; Veronika Komárková; MUDr. Robert Pytlík, Ph.D.; Filip Teplý, PhD; Miroslav Hájek, PhD
Číslo abstraktu: 2159
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

902. Health Services and Outcomes Research – Malignant Diseases: New/Refined Prognostic Schemes/Pharmacoeconomics

What Is the Most Cost-Effective Strategy for Treating Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia (CML) after Imatinib Loses Patent Exclusivity?

Autoři: Richard A. Larson; David V. Conti, Ph.D.; William V. Padula, PhD; Prof. Jane F. Apperley, MBChB, MD, FRCP, FRCPath; MD Michele Baccarani; MD Ekkehard Eigendorff; MD Francois Guilhot; Joelle Guilhot (Guillhot), PhD; M.D. Francois-Xavier Mahon, Ph.D.; Prof.MD Giovanni Martinelli; prof. MUDr. Jiří Mayer, CSc.; Martin Christian Mueller, MD; MD Dietger W Niederwieser; MD Susanne Saussele; MD Charles A. Schiffer; M.D. Richard T. Silver; MD Bengt Simonsson, PhD; Prof. Dr. Rüdiger Hehlmann
Číslo abstraktu: 738
Kategorie: Maligní lymfomy a leukémie