2013 55th ASH Annual Meeting - účast ČR

101. Red Cells and Erythropoiesis, Structure and Function, Metabolism and Survival, Excluding Iron: Poster II

RUNX1 and NF-E2 Transcriptional Upregulation Is Not Specific For Myeloproliferative Neoplasms But Is Seen In Those Polycythemic Disorders With Augmented HIFs Signaling

Autoři: Mgr. Katarína Kapraľová; Ing. Lucie Lániková (Piterková); MD Felipe R. Lorenzo V, PhD; Mgr. Monika Horváthová, Ph.D.; Doc.RNDr. Vladimír Divoký, Ph.D.; MD Josef T. Prchal
Číslo abstraktu: 2177
Kategorie: Myeloproliferativní nemoci

102. Regulation of Iron Metabolism: Poster I

DMT1-Mutant Erythrocytes Have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress

Autoři: Mgr. Zuzana Židová; Bc. Pavla Pospíšilová; Mgr. Renata Mojzíková (Solná), Ph.D.; Mgr. Katarína Kapraľová; MvDr. Dalibor Doležal; Doc.RNDr. Vladimír Divoký, Ph.D.; Mgr. Monika Horváthová, Ph.D.
Číslo abstraktu: 957
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

102. Regulation of Iron Metabolism: Poster II

Mutation Of The Divalent Metal Transporter (Dmt1) Gene Results In Inefficient Induction Of The Erythroid Transcriptional Program Due To Latter Onset Of GATA-1 and Epor Expression

Autoři: Mgr. Nikola Čuřík, Ph.D.; Mgr. Pavel Burda, Ph.D.; Mgr. Tomáš Zikmund; Bc. Filipp Savvulidi; Mgr. Monika Horváthová, Ph.D.; A. John Strouboulis, Ph.D.; Doc.RNDr. Vladimír Divoký, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 2197
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

112. Thalassemia and Globin Gene Regulation: Poster III

Heme Oxygenase 1 Plays a Role In The Pathophysiology Of β-Thalassemia

Autoři: Daniel Garcia Santos, Ph.D.; Marc Mikhael, PhD; Stefano Rivella, Ph.D.; Mgr. Monika Horváthová, Ph.D.; M.D. Prem Ponka, Ph.D.
Číslo abstraktu: 3449
Kategorie: Myeloproliferativní nemoci

311. Disorders of Platelet Number or Function: Poster II

Results From a Phase IV Open-Label Study Evaluating Changes In Bone Marrow Morphology In Adult Immune Thrombocytopenia (ITP) Patients Receiving Romiplostim: Analysis Of The 1- and 2-Year Romiplostim Cohorts

Autoři: MD Ann Janssens; Francesco Rodeghiero; Dr. David Anderson; Beng Chong, MBBS FRCPA FRACP PhD; Zoltan Boda; Ingrid Pabinger; MUDr. Libor Červinek, Ph.D.; Xuena Wang; Angela Lopez
Číslo abstraktu: 2312
Kategorie: Myeloproliferativní nemoci

322. Disorders of Coagulation or Fibrinolysis: Inhibitors in Hemophilia A

The EPIC Study: A Clinical Trial To Assess Whether Early Low Dose Prophylaxis In The Absence Of Immunological Danger Signals Reduces Inhibitor Incidence In Previously Untreated Patients (PUPs) With Hemophilia A

Autoři: M.D. Guenter Auerswald; M.D. Karin Kurnik; MUDr. Jan Blatný, Ph.D.; M.D. Armin J. Reininger
Číslo abstraktu: 576
Kategorie: Myeloproliferativní nemoci

322. Disorders of Coagulation or Fibrinolysis: Poster III

Latest Results From The PUP-GCP Clinical Trial: A Low Inhibitor Rate In Previously Untreated Patients With Severe Hemophilia A Treated With Octanate

Autoři: Anna Klukowska; Martina Jansen; MUDr. Vladimír Komrska, CSc.; M.D. Pawel Laguna, Ph.D.; M.D. Vladimir Vdovin; Sigurd Knaub, Ph.D.
Číslo abstraktu: 3596
Kategorie: Myeloproliferativní nemoci

508. Bone Marrow Failure: Poster II

Erythropoiesis and Iron Metabolism In Diamond-Blackfan Anemia

Autoři: doc.MUDr. Dagmar Pospíšilová, Ph.D.; Mgr. Dušan Holub; Mgr. Zuzana Židová; MUDr. Barbora Ludiková; MUDr. Lucie Sulovská; Doc.RNDr. Vladimír Divoký, Ph.D.; Mgr. Monika Horváthová, Ph.D.
Číslo abstraktu: 2478
Kategorie: Myeloproliferativní nemoci

601. Chromosomal Rearrangements and DNA Repair

RAG-Mediated Recombination Is The Predominant Driver Of Oncogenic Rearrangement In ETV6-RUNX1 Acute Lymphoblastic Leukemia

Autoři: Elli Papaemmanuil, Ph.D.; Yilong Li; Nicola E. Potter, Ph.D.; David Wedge; Giovanni (Gianni) Cazzaniga, PhD; MD Andrea Biondi; prof. MUDr. Jan Zuna, Ph.D.; Peter Van Loo, Ph.D.; Helena Kempski; Anthony Ford, Ph.D.; Mel Greaves, Ph.D., FRS; Peter Campbell
Číslo abstraktu: 807
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Poster II

Leukemic Pattern Of HOX Gene Expression Is Driven By Genetic Aberrations Through Epigenetic Modifiers

Autoři: Mgr. Júlia Starková, Ph.D.; Mgr. Karolina Škvárová Kramarzová, Ph.D.; Mgr. Karel Fišer, Ph.D.; MUDr. Ester Mejstříková, Ph.D.; Bc. Kateřina Rejlová; Mgr. Martina Slámová; M.D. Harry A. Drabkin; Prof.MUDr. Jan Trka, Ph.D.
Číslo abstraktu: 2504
Kategorie: Maligní lymfomy a leukémie

602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Poster III

CBFβ/MYH11 Hypomethylation Signature In Patients With Acute Myeloid Leukaemia

Autoři: Mgr. Hana Hájková; Markus H.Y. Fritz; MUDr. Jiří Schwarz, CSc.; Ing. Jana Marková; Mgr. Martin Vostrý; Ing. Zdeněk Krejčík, Ph.D.; MUDr. Mgr. Cyril Šálek, Ph.D.; Ing. Ota Fuchs, CSc.; prof. MUDr. Petr Cetkovský, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.; RNDr. Cedrik Haškovec, CSc.; Vladimir Benes
Číslo abstraktu: 3774
Kategorie: Maligní lymfomy a leukémie

Comparison of DNA Methylation and Expression Status Prior Azacytidine Treatment and their Relationship to Overall Survival and Clinical Response of MDS Patients

Autoři: Mgr. Monika Běličková; doc. MUDr. Anna Jonášová, Ph.D.; Mgr. Jitka Veselá; Ing. Eliška Stará (Čechová); Mgr. Andrea Hruštincová (Mrhálková); prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 3777
Kategorie: Myelodysplastický syndrom

603. Oncogenes and Tumor Suppressors: Poster III

BCOR and BCORL1 Mutations In Pediatric Acute Myeloid Leukemia

Autoři: Malou C.H. Hermkens; MD Marry M. van den Heuvel-Eibrink, PhD; Susan T.C.J.M. Arentsen-Peters; Maarten W.J. Fornerod, Ph.D.; MD Andre Baruchel, PhD; prof. MUDr. Jan Starý, DrSc.; MD Dirk Reinhardt, PhD; MD Valerie de Haas, Ph.D.; Prof. MD Rob Pieters, PhD; MD Christian Michel Zwaan, PhD
Číslo abstraktu: 3815
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

604. Molecular Pharmacology, Drug Resistance: Poster III

Sensitivity, Reproducibility and Clinical Utility Of Next-Generation Sequencing (NGS) for BCR-ABL1 Kinase Domain Mutation Screening: Results From The CML Work Package Of The Iron-II (Interlaboratory RObustness Of Next-Generation Sequencing) International Study

Autoři: Simona Soverini; MD Thomas Ernst; Dr. Alexander Kohlmann, PhD; Caterina De Benedittis; Mary Alikian; MD Letizia Foroni, PhD; Mgr. Kateřina Machová (Poláková), Ph.D.; Ing. Adéla Benešová (Broučková), Ph.D.; Yucel Erbilgin; Ozden Hatirnaz; prof. MD Ugur Ozbek, PhD.; Cristina Robledo; MD Jesus Hernandez; Ing. Milena Musilová, Ph.D.; Santiago Barrio, Ph.D.; Dr. Joaquin Martinez-Lopez, M.D., Ph.D.; Renate Kastner; Prof. MD Thomas Lion, PhD; MD Torsten Haferlach; MD Andreas Hochhaus; Prof.MD Giovanni Martinelli
Číslo abstraktu: 3824
Kategorie: Maligní lymfomy a leukémie

Modeling Resistance To Tyrosine Kinase Inhibitors In TEL/ABL-Positive Acute Lymphoblastic Leukemia

Autoři: MUDr. Olga Zimmermannová; prof. MUDr. Jan Zuna, Ph.D.; Mgr. Kateřina Machová (Poláková), Ph.D.; RNDr. Libuše Lizcová; Doc.RNDr. Zuzana Zemanová, CSc.; I-Ming L. Chen, D.V.M., M.S.; MD J.H. Frederik Falkenburg, Ph.D.; Richard C. Harvey, Ph.D.; Prof. Dr. Cheryl L. Willman; Prof.MUDr. Jan Trka, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.
Číslo abstraktu: 3826
Kategorie: Maligní lymfomy a leukémie

Primary T-Prolymphocytic Leukemia (T-PLL) Cells Are Sensitive To BCL-2 and HDAC Inhibitors: Results From High-Throughput Ex Vivo Drug Testing

Autoři: Emma I. Andersson, MSc.; Tea Pemovska, MSc.; Samuli Eldfors, MSc.; M.D. Anneli Lauhio; Paavo Pietarinen, MSc.; prof. MUDr. Edgar Faber, CSc.; M.D. Olli Kallioniemi, Ph.D.; Krister Wennerberg, Ph.D.; Caroline Heckman, Ph.D.; MD Kimmo Porkka, PhD; MD Satu Mustjoki, PhD
Číslo abstraktu: 3828
Kategorie: Maligní lymfomy a leukémie

Downregulation Of Deoxycytidine Kinase In Cytarabine-Resistant Mantle Cell Lymphoma Cells Confers Cross-Resistance To Nucleoside Analogs Fludarabine, Gemcitabine and Cladribine, But Not To Other Classes Of Anti-Lymphoma Agents

Autoři: MUDr. Magdalena Klánová; Mgr. Ondřej Vít; MUDr. Bokang Calvin Maswabi; MUDr. Jan Molinský; Mgr. Jana Pospíšilová; BSc Cory Mavis, MSc; MD Francisco J. Hernandez-Ilizaliturri; doc. MUDr. Martin Vokurka, CSc.; RNDr. Jiří Petrák, CSc.; MUDr. Pavel Klener jr, Ph.D.
Číslo abstraktu: 3835
Kategorie: Maligní lymfomy a leukémie

611. Leukemias: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis I

The Interlaboratory Robustness Of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses Of Hematological Malignancies Performed In 8,867 Cases By An International Network Involving 27 Laboratories

Autoři: Dr. Alexander Kohlmann, PhD; Prof.MD Giovanni Martinelli; Mary Alikian; Valentina Artusi, MSc.; M.D. Bernd Auber; Mgr. Monika Běličková; Ilaria Bronzini, Ph.D.; Giovanni (Gianni) Cazzaniga, PhD; MD Sabina Chiaretti, PhD; MD Thomas Ernst; Dr. phil. nat. Marc Füllgrabe (Fuellgrabe), Ph.D.; MD Christian Gabriel; MD Jesus Hernandez; Joop H. Jansen, PhD; Ilaria Iacobucci, PhD; Prof. MD Thomas Lion, PhD; Laurence Lodé; Dr. Joaquin Martinez-Lopez, M.D., Ph.D.; Prof. Dr. Ken I. Mills, PhD; Maximilian Mossner; Mgr. Kateřina Machová (Poláková), Ph.D.; Naomi A. Porret, PhD; prof. RNDr. Šárka Pospíšilová, Ph.D.; Prof. Claude Preudhomme, MD; Prof. Dr. Muge (Aydin-) Sayitoglu, Ph.D.; Simona Soverini; Dr. ssa Orietta Spinelli, PhD, BiolSC; M.D. Christian Thiede; MD Peter Vandenberghe (Vandenberge), Ph.D.; M.D. Allen Eng Juh Yeoh; MD Andreas Hochhaus; MD Torsten Haferlach
Číslo abstraktu: 743
Kategorie: Maligní lymfomy a leukémie

611. Leukemias: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster I

Microrna Expression Profiling In Pediatric Acute Myeloid Leukemia Reveals a Tumor-Suppressive Role Of Mir-9 Associated With Translocation (8;21)

Autoři: Stephan Emmrich; Jenny Katsman-Kuipers; Kerstin Henke; Razan Jammal; Felix Engeland; Ferhat Dasci; MD Christian Michel Zwaan, PhD; Monique L. den Boer, PhD, MSc; Lonneke Verboon; prof. MUDr. Jan Starý, DrSc.; MD Andre Baruchel, PhD; MD Valerie de Haas, Ph.D.; Astrid A Danen-van Oorschot, PhD; Prof. MD Rob Pieters, PhD; MD Dirk Reinhardt, PhD; MD Jan-Henning Klusmann; MD Marry M. van den Heuvel-Eibrink, PhD
Číslo abstraktu: 1363
Kategorie: Maligní lymfomy a leukémie

611. Leukemias: Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis: Poster II

Novel Flow Cytometry-Based Method Of Affinity Proteomics Revealing Expression, Post-Translational Modification and Proteolysis In Primary Childhood Acute Leukemias

Autoři: Mgr. Veronika Kanderová; Mgr. Daniela Kužílková; Mgr. Jan Stuchlý; M.D. Weiwei Wu; Anders Holm, Ph.D.; M.D. Heidi Slåstad; Mgr. Karel Fišer, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.; MD Fridtjof Lund-Johansen, PhD; prof. MUDr. Tomáš Kalina, Ph.D.
Číslo abstraktu: 2553
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Backtracking Of The Genetic Events Preceding Acute Leukemia Diagnosis

Autoři: MUDr. Olga Zimmermannová; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; MUDr. Ester Mejstříková, Ph.D.; MUDr. Eva Froňková, Ph.D.; Prof. RNDr. Mgr. Marie Jarošová, CSc.; Doc.RNDr. Zuzana Zemanová, CSc.; RNDr. Libuše Lizcová; Halima A. Al-Shehhi; Anthony V. Moorman, PhD; prof. MUDr. Ajay J. Vora, MD, FRCP, FRCPath; Claus Meyer; Rolf Marschalek; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 2562
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

Epigenetic Status Of CEBPA Promoter and Expression Of CEBPα Correlates With Molecular Genetic Subtype and CD2 Aberrant Expression In B Cell Precursor ALL

Autoři: MUDr. Lucie Slámová; Mgr. Júlia Starková, Ph.D.; Mgr. Karel Fišer, Ph.D.; MUDr. Eva Froňková, Ph.D.; Bc. Leona Rezková Řezníčková; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; MUDr. Kamila Polgárová; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; Prof. MUDr. Ondřej Hrušák, Ph.D.; MUDr. Ester Mejstříková, Ph.D.
Číslo abstraktu: 2573
Kategorie: Maligní lymfomy a leukémie

615. Acute Myeloid Leukemia: Therapy, excluding Transplantation: Poster II

Safety and Pharmacokinetics Of Clofarabine In Combination With High-Dose Cytarabine and Liposomal Daunorubicin In Pediatric AML: Results Of a Phase 1 Combination Study By The ITCC Consortium

Autoři: MD Christian Michel Zwaan, PhD; Prof. MD Michael Dworzak; M.D. Thomas Klingebiel; M.D. Claudia Rossig; M.D. Guy Leverger; prof. MUDr. Jan Starý, DrSc.; MD Eveline S.J.M. de Bont, PhD; Satianand Ramnarain, MSc; M.D. Yves Bertrand; M.D. Essam A. Ghazaly; MD Dirk Reinhardt, PhD
Číslo abstraktu: 2693
Kategorie: Maligní lymfomy a leukémie

621. Hodgkin Lymphoma: Biology, excluding Therapy: Genomics

A Meta-Analysis Of Hodgkin Lymphoma Reveals 19p13.3 (TCF3) As a Novel Susceptibility Loc

Autoři: D.O. Wendy Cozen, M.P.H.; M.D. Dalin Li, Ph.D.; Maria Timofeeva, Ph.D.; M.D. Arjan Diepstra, Ph.D.; Denis Hazelett, Ph.D.; Manon Delahaye-Sourdeix, M.S.; Christopher K. Edlund, M.S.; Klaus Rostgaard, Ph.D.; David J. van den Berg; Lude Franke, Ph.D.; M.D. Karin Ekström Smedby, Ph.D.; Sally L. Glaser, Ph.D.; Harm-Jam Westra, Ph.D.; Leslie L. Robinson, Ph.D.; Prof. M.D. Thomas M. Mack, M.P.H.; M.D. Herve Ghesquieres, Ph.D.; Amie E. Hwang, Ph.D., M.P.H.; Alexandra Nieters, Ph.D., M.P.H.; M.D. Silvia de Sanjosé, Ph.D.; Victoria K. Cortessis, Ph.D.; Dr. Tracy Lightfoot; M.D. Nikolaus Becker, Ph.D.; M.D. Marc Maynadie, Ph.D.; Doc.MUDr. Lenka Foretová , Ph.D.; Prof. M.D. Eve Roman; Yolanda Benavente, Ph.D.; Dr. Bharat N. Nathwani; M.D. Bengt Glimelius, Ph.D.; Prof. MUDr. Anthony Staines, Ph.D.; M.D. Paolo Boffetta, M.P.H.; M.D. Brian K. Link; Lambertus A. Kiemeney, Ph.D.; M.D. Stephen M. Ansell, Ph.D.; M.D. Smita Bhatia, Ph.D.; Dr. Louise C. Strong, Ph.D.; M.D. Pilar Galan; M.D. Lars Vatten, Ph.D.; M.D. Thomas M. Habermann; Eric J. Duell, Ph.D., M.S.; Annette Lake, M.S.; Rianne Veenstra; M.D. Lydia Visser, Ph.D.; Kevin Urayama, Ph.D.; Dorothy Montgomery; Valerie Gaborieau; M.D. Lawrence Weiss; Dr. Graham Byrnes; Dr. Marc Lathrop, Ph.D.; Prof. M.D. Hans-Olov Adami, Ph.D.; Prof. M.D. Mads Melbye, DMSc; M.D. James R. Cerhan, Ph.D.; M.D. Alice Gallagher; M.D. J. Malcom Taylor; M.D. Susan L. Slager, Ph.D.; M.D. Paul Brennan, Ph.D.; David V. Conti, Ph.D.; Prof. M.D. Gerhard Coetzee, Ph.D.; M.D. Kenan Onel, Ph.D.; Prof. M.D. Ruth F. Jarrett, Ph.D.; M.D. Henrik Hjalgrim, Ph.D.; M.D. Anke Van Den Berg, Ph.D.; M.D. James D. McKay, Ph.D.
Číslo abstraktu: 626
Kategorie: Maligní lymfomy a leukémie

622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Poster I

Oncogenic Micrornas In Cerebrospinal Fluid and Sera Reflect Therapy Efficacy and Their Reappearance Precedes Clinical Relapse In Primary and Secondary CNS Lymphoma

Autoři: Mgr. Vít Pospíšil; MUDr. Heidi Móciková, Ph.D.; MUDr. Magdalena Klánová; MUDr. Monika Paličková; doc. MUDr. Tomáš Kozák, Ph.D., MBA; Prof. MUDr. Marek Trněný, CSc.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 1777
Kategorie: Maligní lymfomy a leukémie

622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Poster II

Ongoing Antigen Interactions In Splenic Marginal Zone Lymphoma: Revelations From The Analysis Of Intraclonal Diversification In Immunoglobulin Light Chain Genes

Autoři: Maria Karypidou; Evangelia Stalika; Panagiotis Baliakas; Vasilis Bikos; Zadie Davis; George Kanellis; Dr. Achilles Anagnostopoulos; MD Theodora Papadaki, Ph.D.; Prof. David Graham Oscier; Anastasia Hadzidimitriou; Dr. Nikos Darzentas, PhD; MD Chrysoula Belessi; MD Kostas Stamatopoulos
Číslo abstraktu: 2999

622. Non-Hodgkin Lymphoma: Biology, excluding Therapy: Poster III

Improved Igh-Based MRD Detection By Using Droplet Digital PCR: a Comparison With Real Time Quantitative PCR In MCL and MM

Autoři: Daniela Drandi; Mgr. Lenka Bešše (Kubiczková); Nadia Dani; Simone Ferrero; Luigia Monitillo; Barbara Mantoan; Elisa Genuardi; Daniela Barbero; Manuela Gambella; Davide Barberio; Paola Ghione; Guglielmo Guarona; Elona Saraci; Paola Omede; Roberto Passera; prof. MUDr. Roman Hájek, CSc.; M.D. Sergio Cortelazzo; MD Antonio P. Palumbo; MD Mario Boccadoro; Giorgio Inghirami; Dr. Marco Ladetto
Číslo abstraktu: 4290
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

623. Lymphoma: Chemotherapy, excluding Pre-Clinical Models: Poster III

Frontline Intensive Chemotherapy Brings Survival Benefit In Young, Risky Patients With Follicular Lymphoma: Pair-Matched Analysis From The Czech Lymphoma Study Group (CLSG) Database

Autoři: MUDr. Vít Procházka, Ph.D.; Prof. MUDr. Marek Trněný, CSc.; Doc.MUDr. Andrea Janíková, Ph.D.; MUDr. David Belada, Ph.D.; doc. MUDr. Tomáš Kozák, Ph.D., MBA; doc. MUDr. Tomáš Papajík, CSc.; MUDr. Vít Campr, Ph.D.; MUDr. David Šálek, Ph.D.; MUDr. Robert Pytlík, Ph.D.; MUDr. Alice Sýkorová, Ph.D.; MUDr. Milada Jankovská; Jitka Dlouhá
Číslo abstraktu: 4354
Kategorie: Maligní lymfomy a leukémie

624. Lymphoma: Therapy with Biologic Agents, excluding Pre-Clinical Models: Poster III

Impact Of Rituximab Maintenance Schedule On Prognosis In First Line Treatment Of Follicular Lymphoma. Retrospective Analysis From Czech Lymphoma Group (CLG) Database

Autoři: Doc.MUDr. Andrea Janíková, Ph.D.; Mgr. Zbyněk Bortlíček; MUDr. Vít Campr, Ph.D.; doc. MUDr. Leoš Křen, Ph.D.; MUDr. David Belada, Ph.D.; MUDr. Vít Procházka, Ph.D.; MUDr. Robert Pytlík, Ph.D.; MUDr. Jan Pirnos; MUDr. Milan Matuška, Ph.D.; doc. MUDr. Tomáš Papajík, CSc.; MUDr. Heidi Móciková, Ph.D.; prof. MUDr. Samuel Vokurka, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 4387
Kategorie: Maligní lymfomy a leukémie

Radiotherapy With Rituximab Is Better than Radiotherapy alone In First Line Treatment Of Localized Follicular Lymphoma. Time To Change a Standard Strategy?

Autoři: Doc.MUDr. Andrea Janíková, Ph.D.; MUDr. Kateřina Benešová, CSc.; Mgr. Zbyněk Bortlíček; MUDr. Vít Campr, Ph.D.; Nataša Kopalová; MUDr. David Belada, Ph.D.; MUDr. Vít Procházka, Ph.D.; MUDr. Robert Pytlík, Ph.D.; prof. MUDr. Samuel Vokurka, Ph.D.; MUDr. Jan Pirnos; MUDr. Milan Matuška, Ph.D.; MUDr. Heidi Móciková, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 4388
Kategorie: Maligní lymfomy a leukémie

624. Lymphoma: Therapy with Biological Agents, Excluding Pre-Clinical Models: Aggressive Lymphomas

Rituximab Maintenance Significantly Prolongs Event Free (EFS) and Progression Free Survival (PFS) In Male Patients With Aggressive B-Cell Lymphoma In The NHL13 Study

Autoři: M.D. Ulrich Jaeger; Prof. MUDr. Marek Trněný, CSc.; Helen Melzer; Michael Praxmarer; Prim. Univ. Doz. Dr. Michael Fridrik; MD Weersak Nawarawong; M.D. Dina Ben-Yehuda; Biljana Mihaljevic, Ph.D.; Dr. Osman Ilhan; MUDr. Veronika Ballová; MD Michael Hedenus, Ph.D.; MD Liang-Tsai Hsiao; M.D. Wing-Yan Au; Dr. Josef Thaler, Ph.D.; Dr. Gerhard Weidinger; M.D. Felix Keil; Prim. Univ. Prof. Dr. Christian Dittrich; Cathrin Skrabs; Daniela Wolkersdorfer; Dr. Anton Klingler; MD Richard Greil, Ph.D.; David Goldstein
Číslo abstraktu: 851
Kategorie: Maligní lymfomy a leukémie

624. Lymphoma: Therapy with Biological Agents, Excluding Pre-Clinical Models: Immunotherapy for Indolent Lymphomas

Updated 6 Year Follow-Up Of The PRIMA Study Confirms The Benefit Of 2-Year Rituximab Maintenance In Follicular Lymphoma Patients Responding To Frontline Immunochemotherapy

Autoři: MD Gilles Andre Salles, PhD; Prof. John Francis Seymour, MD, PhD, MBBS, FRACP; MD Pierre Feugier, PhD; MD Fritz C. Offner, PhD; MD Armando Lopez-Guillermo; MUDr. David Belada, Ph.D.; MD Luc Xerri, PhD; MD Reda Bouabdallah; MBBS John V. Catalano, FRACP FRCPA; MD Pauline Brice; MD Dolores Caballero; Corinne Haioun; MD Lars Moller Pedersen, PhD; Alain Delmer; M.D. David Simpson, FRACP, FRCPA, MBChB; prof. Sirpa Leppä; Pierre Soubeyran; Anton Hagenbeek; Dr. René-Olivier Casasnovas; M.D. Tanin Intragumtornchai, MSc.; M.D. Christophe Ferme; MD Bertrand Coiffier; M.D. Maria Gomes da Silva, Ph.D.; MD Catherine Sebban; Prof. Dr. Thomas Andrew Lister; Dr. Jane A Estell, MBBS, FRCPA, FRACP; M.D. Gustavo Milone; M.D. Anne Sonet, Ph.D.; MD Herve Tilly
Číslo abstraktu: 509
Kategorie: Maligní lymfomy a leukémie

625. Lymphoma: Pre-Clinical – Chemotherapy and Biologic Agents: Small Molecule Targets in Lymphoma

MLN4924, An Investigational Inhibitor Of NEDD8 Activating Enzyme (NAE), Is Active In Mantle Cell Lymphoma (MCL) Pre-Clinical Models and Enhances Rituximab Activity In Vivo

Autoři: MD Matthew John Barth; BSc Cory Mavis, MSc; Natalie M. Czuczman; Sarah Frys, BSc; MUDr. Pavel Klener jr, Ph.D.; MD Myron Stefan Czuczman; MD Francisco J. Hernandez-Ilizaliturri
Číslo abstraktu: 647
Kategorie: Maligní lymfomy a leukémie

631. Chronic Myeloid Leukemia: Biology and Pathophysiology, excluding Therapy: Poster III

Minor Subclones Harboring Small Insertions and Deletions Probably Due To Aberrant Splicing Can Frequently Be Detected By Deep Sequencing of The BCR-ABL Kinase Domain

Autoři: Caterina De Benedittis; Simona Soverini; Mgr. Kateřina Machová (Poláková), Ph.D.; Ing. Adéla Benešová (Broučková), Ph.D.; MD Fausto Castagnetti; Gabriele Gugliotta; Francesca Palandri; M.D. Cristina Papayannidis; MUDr. Hana Klamová, CSc.; Paola Bresciani; MD Marzia Salvucci; MD Gianni Binotto; Tamara Intermesoli; Ilaria Iacobucci, PhD; Claudia Venturi; Mario Luppi; Emanuela Ottaviani; Maria Teresa Bochicchio; Manuela Mancini; Elisa Leo; MD Torsten Haferlach; Dr. Alexander Kohlmann, PhD; Prof. Domenico Russo; Prof. MD Gianantonio Rosti; MD Michele Baccarani; MD Michele Cavo; Prof.MD Giovanni Martinelli
Číslo abstraktu: 3986
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Algorithms and Processing Pipeline For Error Correction and Detection Of Significant Mutations In The Kinase Domain Of BCR-ABL Analyzed By Next-Generation Sequencing: Implications For Clinical Practice Of Chronic Myeloid Leukemia

Autoři: Mgr. Kateřina Machová (Poláková), Ph.D.; Mgr. Vojtěch Kulvait; Mgr. Jana Linhartová, Ph.D.; Ing. Adéla Benešová (Broučková), Ph.D.; Simona Soverini; MUDr. Monika Jarušková; Caterina De Benedittis; MD Torsten Haferlach; MD Michele Baccarani; Prof.MD Giovanni Martinelli; MUDr. Hana Klamová, CSc.; Dr. Alexander Kohlmann, PhD
Číslo abstraktu: 3987
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Emerging Aspects of Monitoring and Long-Term Treatment

Four-Year (Yr) Follow-Up Of Patients (Pts) With Newly Diagnosed Chronic Myeloid Leukemia In Chronic Phase (CML-CP) Receiving Dasatinib Or Imatinib: Efficacy Based On Early Response

Autoři: M.D. Jorge E. Cortes; MD Andreas Hochhaus; M.D. Dong-Wook Kim; MD Neil Shah, PhD; prof. MUDr. Jiří Mayer, CSc.; M.D. Philip Rowlings; M.D. Hirohisa Nakamae, Ph.D.; M.D. M. Brigid Bradley-Garelik; M.D. Hesham Mohamed; M.D. Hagop M. Kantarjian; MD Giuseppe Saglio, PhD.
Číslo abstraktu: 653
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Poster I

Early PK-Analysis Predicts Molecular Response In Patients With Early Chronic Phase Chronic Myelogenous Leukemia (CML-CP) Treated With Frontline Nilotinib

Autoři: MD Dominik Wolf; Jörn Skavland, Ph.D.; Priv. Doz. Dr. rer. nat. Christoph Seger, Ph.D.; Sieghart Sopper, Ph.D.; Prof. Dr. Wieslaw Wiktor-Jedrzejczak, PhD; Dubravka Sertic; MUDr. Jaroslava Voglová; MD Satu Mustjoki, PhD; MD Leif Stenke, PhD; Prof. Augustin Ferrant; MD Richard Greil, Ph.D.; Dr. Alois Lang; Dr. Josef Thaler, Ph.D.; Univ.-Prof. Dr.med.univ. Werner Linkesch; MD Antica Duletić-Načinović, PhD; MD Andrzej Hellmann, Ph.D.; Prof. M.D. Georgi Mihaylov, Ph.D.; MD Tobias Gedde-Dahl, PhD; M.D. Henrik Hjort-Hansen, Ph.D.; M.D. Waleed Majeed; MD Jesper Stentoft, PhD; Prof. Dr. Gregor Verhoef, Ph.D.; MD Jan van Droogenbroeck, PhD; Ute Mark; Dr. Jens Haenig; Nidas Jurjonas; Prof. MD Frank Giles, M.B.; MD Andreas Hochhaus; MD Kimmo Porkka, PhD; MD Gert (J.) Ossenkoppele, PhD; Prof. MD Bjoern-Tore Gjertsen, PhD
Číslo abstraktu: 1485
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Poster II

CML Patients In Clinical Trials Represent Fairly Well The General Population Of CML Patients: A Comparative Analysis Of 5803 Patients From The EUTOS Registry

Autoři: Dr. rer. biol. hum. Verena Sophia Hoffmann, BSc, M.A.; Dipl. Inf. Doris Lindörfer (Lindoerfer); Dr. rer. biol. hum. Markus Pfirrmann, M.Sc.; MD Susanne Saussele; MD Andreas Hochhaus; Prof. Dr. Jutta Engel, Ph.D.; Joelle Guilhot (Guillhot), PhD; Prof. MD Gianantonio Rosti; prof. MUDr. Jiří Mayer, CSc.; prof. MUDr. Karel Indrák, DrSc.; MD Fausto Castagnetti; MD Anna Turkina, PhD; MD Andrey Zaritsky (Zaritskey); MD Juan Luis Steegmann, PhD; MD Andrzej Hellmann, Ph.D.; M.D. Noortje Thielen; MD Francisco Cervantes; MD Bengt Simonsson, PhD; Dr. Adriana Colita; Dr. Richard E. Clark, MBBS, MD, FRCP, FRCPath; MD Antonio Medina Almeida, PhD; Boris Labar, MD, PhD; M.D. David Marin; MD Gert (J.) Ossenkoppele, PhD; Andrija Bogdanovic; Dr. Irina Dyagil; MD Kimmo Porkka, PhD; Prof. Dr. Steve (Stephen) O'Brien, PhD; M.D. Laimonas Griskevicius (Griškevičius); M.D. Panagiotis Panagiotidis; Dr. Josef Thaler, Ph.D.; M.D. Irena Zupan, Ph.D.; M.D. Sandra Lejniece, Ph.D.; Prof. M.D. Hele Everaus (1953-), Ph.D.; MD Tamas Masszi, PhD; Dr. Frederiki Melanthiou; Prof. Dr. Rüdiger Hehlmann; MD Joerg Hasford; MD Michele Baccarani
Číslo abstraktu: 2735
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Poster III

Factors Predicting Intentional Non-Adherence In Chronic Myeloid Leukemia: A Multivariate Analysis On 2546 Patients By The CML Advocates Network

Autoři: Jan Geissler; Fabio Efficacce, PhD; Dr. Felice Bombaci; Jan de Jong; Anthony Gavin; Euzebiusz Ján Dziwinski; Mina Daban; Jana Pelouchová; Dr. Francesco Cottone; Joelle Guilhot (Guillhot), PhD; Giora Sharf
Číslo abstraktu: 4023
Kategorie: Maligní lymfomy a leukémie

632. Chronic Myeloid Leukemia: Therapy: Prognosis

Ultra Deep Sequencing (UDS) Allows More Sensitive Detection Of Tyrosine Kinase Inhibitor (TKI)-Resistant BCR-ABL Mutations That Would Influence Therapeutic Decision At The Time Of Switchover To Second- Or Third-Line Therapy

Autoři: Simona Soverini; Caterina De Benedittis; Mgr. Kateřina Machová (Poláková), Ph.D.; Ing. Adéla Benešová (Broučková), Ph.D.; MD Fausto Castagnetti; Gabriele Gugliotta; Francesca Palandri; M.D. Cristina Papayannidis; Ilaria Iacobucci, PhD; Claudia Venturi; Manuela Mancini; Elisa Leo; MUDr. Hana Klamová, CSc.; Stefania Paolini; Prof. Domenico Russo; Prof. MD Gianantonio Rosti; MD Michele Baccarani; MD Michele Cavo; Prof.MD Giovanni Martinelli
Číslo abstraktu: 380
Kategorie: Maligní lymfomy a leukémie

633. Myelodysplastic Syndromes: Poster I

High Cereblon Expression In Lower Risk Myelodysplastic Syndromes With 5q Deletion Is Associated With The Efficacy Of Lenalidomide

Autoři: doc. MUDr. Anna Jonášová, Ph.D.; Mgr. Jaroslav Polák; Mgr. Martin Vostrý; Mgr. Arnošt Kostečka; Mgr. Radka Bokorová; doc. MUDr. Radana Neuwirtová, CSc.; MUDr. Magda Šišková, CSc.; MUDr. Miroslav Čaniga; MUDr. Dana Šponerová; prof. MUDr. Jaroslav Čermák, CSc.; MUDr. Dana Mikulenková; RNDr. Jana Březinová, Ph.D.; prof. Ing. Kyra Michalová, DrSc.; Ing. Ota Fuchs, CSc.
Číslo abstraktu: 1529
Kategorie: Myelodysplastický syndrom

Time Changes In Predictive Power Of MDS Prognostic Scores – Effects On Revised Scores Such As The IPSS-R, Impact Of Age

Autoři: M.D. Michael Pfeilstöcker; Heinz Tüchler (Tuechler); M.D. Julie Schanz; MD Guillermo F Sanz, PhD; M.D. Guillermo Garcia Manero; M.D. Francesc Solé, Ph.D.; Prof. M.D. John M. Bennett; MD David Bowen, Ph.D.; MD Pierre Fenaux, PhD; M.D. Francois Dreyfus; M.D. Hagop M. Kantarjian; M.D. Andrea Kuendgen; M.D. Alessandro Levis; MD Luca Malcovati; M.D. Mario Cazzola; prof. MUDr. Jaroslav Čermák, CSc.; Christa Fonatsch, Ph.D.; Michelle Lebeau (LeBeau), Ph.D.; Marilyn L. Slovak, Ph.D.; M.D. Otto Krieger; Prof. Dr. Michael Luebbert (Lübbert), Ph.D.; M.D. Jaroslaw P. Maciejewski, Ph.D., FACP; M.D. Silvia M. M. Magalhaes; M.D. Yasushi Miyazaki, Ph.D.; M.D. Mikkael A. Sekeres, M.S.; Wolfgang R. Sperr, M.D.; MD Reinhard Stauder; Dr. Sudhir Tauro, PhD, FRCPath; Prof. Dr. Peter Valent; M.D. Teresa Vallespi, Ph.D.; M.D. Arjan A. van de Loosdrecht, Ph.D.; MD Ulrich Germing; M.D. Detlef Haase, Ph.D.; Prof. M.D. Peter L. Greenberg
Číslo abstraktu: 1544
Kategorie: Myelodysplastický syndrom

Erythroid Transcription Factor GATA-1 Binds and Represses PU.1 Gene – Candidate Mechanism Of Epigenetic Repression Of PU.1 and Inefficient Erythropoiesis In MDS

Autoři: Mgr. Pavel Burda, Ph.D.; Mgr. Nikola Čuřík, Ph.D.; MUDr. Nina Dusílková; Giorgio L. Papadopoulos, Ph.D.; A. John Strouboulis, Ph.D.; doc. MUDr. Anna Jonášová, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 1558
Kategorie: Myelodysplastický syndrom

Putative Monosomy 5 In Myelodysplastic Syndromes (MDS) Is Probably Resulting From Chromothripsis

Autoři: Doc.RNDr. Zuzana Zemanová, CSc.; prof. Ing. Kyra Michalová, DrSc.; Mgr. Halka Lhotská Buryová; RNDr. Jana Březinová, Ph.D.; RNDr. Libuše Lizcová; Mgr. Karla Kostýlková Svobodová; RNDr. Iveta Šárová; Mgr. Silvia Izáková; Mgr. Šárka Ransdorfová (Kurková), Ph.D.; Ing. Zdeněk Krejčík, Ph.D.; Ing. Michaela Dostálová-Merkerová, Ph.D.; MUDr. Magda Šišková, CSc.; doc. MUDr. Anna Jonášová, Ph.D.; doc. MUDr. Radana Neuwirtová, CSc.; prof. MUDr. Jaroslav Čermák, CSc.
Číslo abstraktu: 1559
Kategorie: Myelodysplastický syndrom

633. Myelodysplastic Syndromes: Poster II

Validation Of The Revised International Prognostic Scoring System (IPSS-R) In 1000 Newly Diagnosed MDS Patients With Low- and Intermediate-1 Risk MDS In The European Leukemianet MDS (EUMDS) Registry

Autoři: MD Louise de Swart; Alexandra Smith; Dr. Tom Johnston; M.D. Detlef Haase, Ph.D.; Jackie Droste; MD Pierre Fenaux, PhD; Dr. Argyris Symeonidis, Ph.D.; MD Guillermo F Sanz, PhD; MD Eva Hellström-Lindberg; prof. MUDr. Jaroslav Čermák, CSc.; MD Ulrich Germing; MD Reinhard Stauder; Otilia Georgescu; Marius MacKenzie; MD Luca Malcovati; MD Mette Skov-Holm, PhD; MD Antonio Medina Almeida, PhD; MD Krzysztof Madry, PhD; Dr. Borhane Slama ; MD Agnès Guerci-Bresler, Ph.D.; MD Laurence Sanhes; MD Odile Beyne Rauzy, PhD; Dr. Elisa Luno; MD David Bowen, Ph.D.; MD Theo de Witte, PhD
Číslo abstraktu: 2770
Kategorie: Myelodysplastický syndrom

635. Myeloproliferative Syndromes: Basic Science: Poster I

Ph-Negative Myeloproliferative Neoplasms Exhibit Some Features Of Warburg Effect

Autoři: M.D. Sherjeel Sana; Maria Navas-Mareno, Ph.D.; Z.Valey Vardney, Ph.D.; Mark Duros, M.S.; MD Felipe R. Lorenzo V, PhD; Mgr. Katarína Kapraľová; Sabina Swierczek, PhD; MD Josef T. Prchal
Číslo abstraktu: 1604
Kategorie: Myeloproliferativní nemoci

641. CLL: Biology and Pathophysiology, excluding Therapy: Poster I

Novel Gene Mutations In Chronic Lymphocytic Leukemia: Prevalence and Clinical Implications In A Series Of 3185 Cases - Initial Results From The European Research Initiative On CLL

Autoři: Panagiotis Baliakas; Anastasia Hadzidimitriou; Lesley-Ann Sutton; M.D. Davide Rossi; Evangelia Minga; M.D. Neus Villamor, Ph.D.; Dr. Marta Larrayoz; PharmDr. Jana Kmínková; Andreas Agathangelidis; Zadie Davis; Dr. Eugen Tausch; Evangelia Stalika; RNDr. Jitka Malčíková, Ph.D.; Larry Mansouri; Lydia Scarfo; Diego Cortese; Mgr. Karla Plevová, Ph.D.; M.D. Karin Ekström Smedby, Ph.D.; Prof. MD Gunnar Juliusson, PhD; Antonios Makris; Alba Navarro (Lopez), Ph.D.; M.D. Julio Delgado, Ph.D.; Prof. David Graham Oscier; MD Chrysoula Belessi; MD Stephan Stilgenbauer; M.D. Paolo Ghia, Ph.D.; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Gianluca Gaidano, PhD; M.D. Elias Campo, Ph.D.; MD Kostas Stamatopoulos; BSc. Jonathan C. Strefford, PhD; Prof. MD Richard Rosenquist (Brandell), PhD
Číslo abstraktu: 1614
Kategorie: Maligní lymfomy a leukémie

A Multicenter, Phase IV Observational Study Of Ofatumumab In Chronic Lymphocytic Leukemia (CLL): A European Research Initiative On CLL (ERIC) Study

Autoři: M.D. Carol Moreno; MD Marco Montillo; M.D. Panayiotis Panayiotidis, Ph.D.; Dr. Adrian Bloor, Ph.D., FRCP, FRCPath; Dr. Jehan Dupuis; M.D. Anna Schuh, Ph.D.; M.D. Stefan Norin; MD Christian H. Geisler, PhD; Peter Hillmen, M.B. ChB, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Petra Obrtlíková, Ph.D.; MD Luca Laurenti; MD Stephan Stilgenbauer; MUDr. Lukáš Smolej, Ph.D.; M.D. Paolo Ghia, Ph.D.; M.D. Florence Cymbalista, Ph.D.; M.D. Ulrich Jaeger; Niki Stavroyianni; Dr. Patrick Carrington, MB ChB, MRCP, FRCPath; M.D. Hamadi Zouabi; M.D. Veronique Leblond; Dr. Juan Gomez; M.D. Roberto Marasca; Dr. Gerardo Musuraca; Dr. Luigi Rigacci; Dr. Lucia Farina; MD Rossella Paolini; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Eva Kimby, PhD; Colm Bradley; Prof. Dr. Emili Montserrat
Číslo abstraktu: 1645
Kategorie: Maligní lymfomy a leukémie

641. CLL: Biology and Pathophysiology, excluding Therapy: Poster II

SF3B1 Mutations Frequently Occur With Both ATM Mutations and TP53 Mutations In CLL Patients

Autoři: Mgr. Veronika Navrkalová, Ph.D.; RNDr. Jitka Malčíková, Ph.D.; Mgr. Barbara Kantorová; RNDr. Ludmila Šebejová; Mgr. Karla Plevová, Ph.D.; MUDr. Mgr. Marek Mráz, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. RNDr. Jana Šmardová, CSc.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.; Doc. MUDr. Martin Trbušek, PhD
Číslo abstraktu: 2868
Kategorie: Maligní lymfomy a leukémie

641. CLL: Biology and Pathophysiology, excluding Therapy: Poster III

Differential Distribution Of Recurrent Gene Mutations In Subsets Of Chronic Lymphocytic Leukemia Patients With Stereotyped B-Cell Receptors: Results From A Multicenter Project Of The European Research Initiative On CLL In A Series Of 2482 Cases

Autoři: Panagiotis Baliakas; Anastasia Hadzidimitriou; Lesley-Ann Sutton; M.D. Davide Rossi; Evangelia Minga; Andreas Agathangelidis; M.D. Neus Villamor, Ph.D.; PharmDr. Jana Kmínková; Dr. Marta Larrayoz; Zadie Davis; Evangelia Stalika; RNDr. Jitka Malčíková, Ph.D.; Antonios Makris; Larry Mansouri; Lydia Scarfo; Diego Cortese; Mgr. Karla Plevová, Ph.D.; Prof. MD Gunnar Juliusson, PhD; Alba Navarro (Lopez), Ph.D.; M.D. Julio Delgado, Ph.D.; Prof. David Graham Oscier; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Gianluca Gaidano, PhD; M.D. Elias Campo, Ph.D.; BSc. Jonathan C. Strefford, PhD; MD Chrysoula Belessi; M.D. Paolo Ghia, Ph.D.; Prof. MD Richard Rosenquist (Brandell), PhD; MD Kostas Stamatopoulos
Číslo abstraktu: 4113
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Clonal Evolution and Therapy Related Selection Of TP53 Mutations In Chronic Lymphocytic Leukemia Patients

Autoři: Mgr. Karla Plevová, Ph.D.; RNDr. Jitka Malčíková, Ph.D.; Doc. MUDr. Martin Trbušek, PhD; Mgr. Šárka Pavlová, PhD; RNDr. Ludmila Šebejová; MvDr. Boris Tichý, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 4126
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

A Systematic Search Into The Role Of IGHV Gene Replacement In Shaping The Immunoglobulin Repertoire Of Chronic Lymphocytic Leukemia

Autoři: Sophia Yancopoulos, Ph.D.; M.D. Xiao-Jie Yan, Ph.D.; Andreas Agathangelidis; Wentian Li, Ph.D.; MD Chrysoula Belessi; M.D. Paolo Ghia, Ph.D.; Prof. MD Richard Rosenquist (Brandell), PhD; MD Frederic Davi, PhD; Prof. David Graham Oscier; prof. RNDr. Šárka Pospíšilová, Ph.D.; M.D. Panagiotis Panagiotidis; Lin Huang, Ph.D.; Zhixin Zhang, Ph.D.; M.D. Steven L. Allen; M.D. Jacqueline C. Barrientos; M.D. Jonathan E. Kolitz; M.D. Kanti R. Rai; MD Kostas Stamatopoulos; MD Nicholas Chiorazzi
Číslo abstraktu: 4129
Kategorie: Maligní lymfomy a leukémie

642. CLL: Therapy, excluding Transplantation: Chemoimmunotherapy Clinical Trials

Chemoimmunotherapy With Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Versus Bendamustine and Rituximab (BR) In Previously Untreated and Physically Fit Patients (pts) With Advanced Chronic Lymphocytic Leukemia (CLL): Results Of a Planned Interim Analysis Of The CLL10 Trial, An International, Randomized Study Of The German CLL Study Group (GCLLSG)

Autoři: MD Barbara Eichhorst; MD Anna-Maria Fink; Dipl.Math. Raymonde Busch, Ph.D.; M.D. Elisabeth Lange; Prof. Dr. Hubert Köppler; M.D. Michael Kiehl; M.D. Martin Soekler (Sökler); MD Rudolf Schlag; MD Ursula Vehling-Kaiser; M.D. Georg Köchling (Koechling); M.D. Christoph Plöger (Ploeger); M.D. Michael Gregor; MD Torben Plesner; Prof. MUDr. Marek Trněný, CSc.; M.D. Kirsten Fischer; Prof. Dr. med. Hartmut Döhner (Doehner); MD Michael Kneba, PhD; MD Clement Martin Wendtner; MD Wolfram Klapper, PhD; M.D. Karl-Anton Kreuzer; MD Stephan Stilgenbauer; MD Sebastian Böttcher; Prof. MD Michael Hallek
Číslo abstraktu: 526
Kategorie: Maligní lymfomy a leukémie

NOTCH1 Mutation and Treatment Outcome In CLL Patients Treated With Chlorambucil (Chl) Or Ofatumumab-Chl (O-Chl): Results From The Phase III Study Complement 1 (OMB110911)

Autoři: Dr. Eugen Tausch; Philipp Beck; M.D. Richard F. Schlenk; Sabrina Kless; Christina Galler; Peter Hillmen, M.B. ChB, Ph.D.; MD Fritz C. Offner, PhD; MD Ann Janssens; Dr. K. Govind Babu, D.M.; M.D. Sebastian Grosicki; prof. MUDr. Jiří Mayer, CSc.; M.D. Panagiotis Panagiotidis; M.D. Susanne Danhauser-Riedl; Astrid McKeown, Ph.D.; Paul D. Winter; MD Ira (V.) Gupta; Prof. Dr. med. Hartmut Döhner (Doehner); MD Stephan Stilgenbauer
Číslo abstraktu: 527
Kategorie: Maligní lymfomy a leukémie

Ofatumumab + Chlorambucil Versus Chlorambucil Alone In Patients With Untreated Chronic Lymphocytic Leukemia (CLL): Results Of The Phase III Study Complement 1 (OMB110911)

Autoři: Peter Hillmen, M.B. ChB, Ph.D.; MD Tadeusz Robak, PhD.; MD Ann Janssens; Dr. K. Govind Babu, D.M.; M.D. Sebastian Grosicki; prof. MUDr. Jiří Mayer, CSc.; M.D. Panagiotis Panagiotidis; MD Eva Kimby, PhD; M.D. Anna Schuh, Ph.D.; M.D. Thomas Boyd; MD Marco Montillo; Astrid McKeown, Ph.D.; RN Jodi L. Carey, BSN; MD Ira (V.) Gupta; Chai-Ni Chang, M.S.; MD Steen Lisby, DMSc; MD Fritz C. Offner, PhD
Číslo abstraktu: 528

642. CLL: Therapy, excluding Transplantation: Poster II

Ofatumumab Added To Dexamethasone In Patients With Relapsed Or Refractory Chronic Lymphocytic Leukemia. Results From a Phase II Study Of The Czech Leukemia Study Group For Life

Autoři: prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; MUDr. Anna Panovská; MUDr. Jakub Trizuljak; RNDr. Ludmila Šebejová; Ing. Olga Stehliková; MVDr. Jana Chovancová; RNDr. Jitka Malčíková, Ph.D.; prof. RNDr. Jana Šmardová, CSc.; Mgr. Karla Plevová, Ph.D.; Mgr. Pavlína Volfová; Doc. MUDr. Martin Trbušek, PhD; MUDr. Mgr. Marek Mráz, Ph.D.; MUDr. Denisa Majerčáková; MUDr. Petra Obrtlíková, Ph.D.; MUDr. Josef Karban, CSc.; MUDr. Lukáš Smolej, Ph.D.; MUDr. Michaela Lindtnerová; RNDr. Alexandra Oltová; Eva Jelínková; prof. RNDr. Šárka Pospíšilová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 2877
Kategorie: Maligní lymfomy a leukémie

642. CLL: Therapy, excluding Transplantation: Poster III

Rituximab and High-Dose Dexamethasone (R-dex) Is Effective In The Treatment Of Relapsed/Refractory Chronic Lymphocytic Leukemia

Autoři: MUDr. Martin Šimkovič; MUDr. David Belada, Ph.D.; MUDr. Monika Motyčková; MUDr. Lukáš Smolej, Ph.D.; Prof. MUDr. Pavel Žák, Ph.D.
Číslo abstraktu: 4184
Kategorie: Maligní lymfomy a leukémie

651. Myeloma: Biology and Pathophysiology, excluding Therapy: Microenvironment

CD56+ Clonal Plasma Cells In Multiple Myeloma Are Associated With Unique Disease Characteristics and Have a Counterpart Of CD56+ Normal Plasma Cells With Increased Maturity

Autoři: Martin Schmidt-Hieber; Bruno Paiva; Martin Perez-Andres, Ph.D.; Maria Laura Gutierrez; Karen Dybkaer, Ph.D.; Ana Rasillo; Maria Dolores Tabernero; Antonio Lopez; MUDr. Fedor Kryukov; Paloma Carrasco; Maria Luz Sanchez; MD Laura Rosiñol, PhD; Dr. Joaquin Martinez-Lopez, M.D., Ph.D.; M.D. Albert Oriol; Felipe de Arriba; M.D. Luis Palomera; Enrique Bengoechea; Juan José Lahuerta; Prof. Dr. Joan Bladé, PhD; Alexander Schmitz; Prof. Hans Erik Johnsen; Prof. M.D. Jesús San Miguel, Ph.D.; Dr. Alberto Orfao, PhD
Číslo abstraktu: 751
Kategorie: Mnohočetný myelom; Nádorová biologie/imunologie/genetika a buněčná terapie

651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I

17p Deleted Multiple Myeloma: Clinical Outcomes and Predictive Factors For Acquisition Of 17p Deletion

Autoři: MUDr. Utkarsh Painuly; Prof. Dr. S. Vincent Rajkumar; Rhett P. Ketterling; M.D. Angela Dispenzieri; M.D. Martha Q. Lacy; M.D. Morie Gertz, MACP; M.D. Francis K. Buadi; M.D. David Dingli, Ph.D.; M.D. Suzanne R. Hayman; M.D. Prashant Kapoor; M.D. Arleigh McCurdy; M.D. Nelson Leung; M.D. John A. Lust, Ph.D.; M.D. Stephen J. Russell, Ph.D.; M.D. Steven R. Zeldenrust, Ph.D.; M.D. Yi Lin, Ph.D.; M.D. Robert A. Kyle, MACP; M.D. Shaji Kumar
Číslo abstraktu: 1846
Kategorie: Mnohočetný myelom

Genome Wide Profiling Of Chromosomal Abnormalities In 37 Patients With Monoclonal Gammopathy Of Undetermined Significance (MGUS)

Autoři: Mgr. Aneta Mikulášová; RNDr. Vladimíra Vallová (Vránová), Ph.D.; Mgr. Jan Smetana; RNDr. Henrieta Grešliková; Renata Kupská; Mgr. Michaela Purgertová; Mgr. Lucie Říhová, PhD.; MUDr. Viera Sandecká, Ph.D.; prof. MUDr. Luděk Pour, Ph.D.; prof. MUDr. Miroslav Penka, CSc.; Prof.RNDr. Petr Kuglík, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 1874
Kategorie: Mnohočetný myelom

Cell Cycle Gene Sets Coordination In Multiple Myeloma and Plasma Cell Leukemia

Autoři: MUDr. Fedor Kryukov; RNDr. Ivana Ihnatová; Mgr. Pavel Němec; Alexander Schmitz; Julie S. Brødker; Malene Krag Kjeldsen; Martin Bøgsted; Prof. Hans Erik Johnsen; prof. MUDr. Roman Hájek, CSc.; Karen Dybkaer, Ph.D.
Číslo abstraktu: 1901
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Poster II

Randomized Placebo-Controlled Phase III Study Of Perifosine Combined With Bortezomib and Dexamethasone In Relapsed, Refractory Multiple Myeloma Patients Previously Treated With Bortezomib

Autoři: MD Paul Gerard Guy Richardson; MD Arnon Nagler, MSc.; M.D. Dina Ben-Yehuda; MD Ashraf Z. Badros; M.D. Parameswaran Hari, M.S.; prof. MUDr. Roman Hájek, CSc.; Prof.MUDr. Ivan Špička, PhD; M.D. Hakan Kaya; M.D. Richard Le Blanc; MD Sung-Soo Yoon, PhD; M.D. Kihyun Kim, Ph.D.; Dr. Joaquin Martinez-Lopez, M.D., Ph.D.; M.D. Moshe Mittelman; MD Ofer Shpilberg, MPH; prof. MUDr. Elena Tóthová, CSc.; M.D. Jacob P. Laubach; M.D. Irene M. Ghobrial; M.D. Merav Leiba; M.D. Moshe E. Gatt; Peter Sportelli; Michael Chen, Ph.D.; MD Kenneth C. Anderson
Číslo abstraktu: 3189
Kategorie: Mnohočetný myelom

Combination Of Lenalidomide, Dexamethasone and Cyclophosphamide as Treatment For The First Relapse Of Multiple Myeloma: Efficacy, Toxicity and Occurance Of Thyroid Abnormalities

Autoři: Prof. MUDr. Marta Krejčí, Ph.D.; prof. MUDr. Zdeněk Adam, CSc.; prof. MUDr. Luděk Pour, Ph.D.; Mgr. Jana Pelcová; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 3233
Kategorie: Mnohočetný myelom

653. Myeloma: Therapy, excluding Transplantation: Treatment Options for Newly Diagnosed Multiple Myeloma Patients

A Randomized Phase 3 Trial Of Melphalan-Lenalidomide-Prednisone (MPR) Or Cyclophosphamide-Prednisone-Lenalidomide (CPR) Vs Lenalidomide Plus Dexamethsone (Rd) In Elderly Newly Diagnosed Multiple Myeloma Patients

Autoři: MD Antonio P. Palumbo; MD Valeria Magarotto; MD Sara Bringhen; M.D. Massimo Offidani; Giuseppe Pietrantuono; Prof. MD Anna Marina Liberati; Giulia Benevolo; Antonio Ledda; Milena Gilestro; MD Monica Galli, PhD; Francesca Patriarca; M.D. Mariella Genuardi; Prof. M.D. Nicola Giuliani; Renato Zambello; prof. MUDr. Zdeněk Adam, CSc.; M.D. Alessia La Fauci; M.D. Paolo Corradini; M.D. Antonietta Pia Falcone; prof. M.D. Caterina Musolino; M.D. Davide Rossi; M.D. Patrizia Caraffa; MD Pellegrino Musto; M.D. Federica Cavallo; prof. MUDr. Roman Hájek, CSc.; MD Mario Boccadoro
Číslo abstraktu: 536
Kategorie: Mnohočetný myelom

722. Clinical Allogeneic Transplantation - Acute and Chronic GVHD, Immune Reconstitution: Poster III

Impact Of Prophylaxis With Defibrotide On The Occurrence Of Acute GvHD In Allogeneic HSCT

Autoři: M.D. Selim Corbacioglu; M.D. Simone Cesaro; MD Maura Faraci; Dr. Bernd Gruhn; M.D. Jaap Jan Boelens, Ph.D.; M.D. Ansgar Schulz; Ingo Mueller; MD Jerry Stein; M.D. Robert Wynn; M.D. Johann Greil; M.D. Karl-Walter Sykora; M.D. Jacek Toporski, Ph.D.; prof. MUDr. Petr Sedláček, CSc.; M.D. Paul G. Schlegel; MD Karoline Ehlert; M.D. Christine Mauz-Koerholz; Peter Bader; Elena Tudone; M.D. Maria Ballabio; M.D. Carin Heringa; MD Christina Peters, Ph.D.
Číslo abstraktu: 4591
Kategorie: Maligní lymfomy a leukémie

731. Clinical Allogeneic and Autologous Transplantation - Results: Allogeneic Transplantation

Allogeneic Stem Cell Transplantation For Acute Myeloid Leukemia With Normal Cytogenetics (CN-AML): Outcome, Risk Factors and Role Of Molecular Subgroups In 752 Patients – A Report From The Acute Leukemia Working Party Of EBMT

Autoři: Dr. Christoph Schmid; MD Myriam Labopin, MS; MD Gerard Socié, Ph.D.; M.D. Alessandro Rambaldi; M.D. Rainer Schwerdtfeger; M.D. Eric Deconinck, Ph.D.; M.D. Stephane Vigouroux; Anne Huynh; MD Liisa Volin, Ph.D.; Prof. M.D. Jean-Henri Bourhis, Ph.D.; M.D. Johan Maertens, Ph.D.; M.D. Patrice Chevalier; MUDr. Pavel Jindra, Ph.D.; M.D. Günther Schlimok; MD Jan Cornelissen, PhD; MD Norbert Ifrah; MD Arnon Nagler, MSc.; Emmanuelle Polge; MD Jordi Esteve, PhD; MD Mohamad Mohty, PhD
Číslo abstraktu: 921
Kategorie: Maligní lymfomy a leukémie

731. Clinical Allogeneic and Autologous Transplantation - Results: Evidence-based Decision Making II - Transplantation for Lymphoma and Plasma Cell Disorders

A Phase III Study Of ASCT Vs Cyclophosphamide-Lenalidomide-Dexamethasone and Lenalidomide-Prednisone Maintenance Vs Lenalidomide Alone In Newly Diagnosed Myeloma Patients

Autoři: MD Antonio P. Palumbo; Francesca Gay; MD Andrew Spencer; M.D. Francesco Di Raimondo; prof. MUDr. Zdeněk Adam, CSc.; MD Alessandra Larocca; M.D. Antonietta Pia Falcone; Lucio Catalano; M.D. Paola Finsinger; Prof.MUDr. Vlastimil Ščudla, CSc.; Simona Aschero; M.D. Massimo Offidani; Prof. MD Anna Marina Liberati; M.D. Angelo Michele Carella; Doc. MUDr. Vladimír Maisnar, Ph.D.; Francesca Donato; MD Tommaso Caravita; M.D. Paolo Corradini; Dr. Roberto Ria; M.D. Stefano Pulini; Raffaella Stocchi; Concetta Conticello; MD Maria Teresa Petrucci; prof. MUDr. Roman Hájek, CSc.; MD Mario Boccadoro
Číslo abstraktu: 763
Kategorie: Maligní lymfomy a leukémie

Diffuse Large B-Cell Lymphoma (DLBCL) Patients Failing Second-Line R-DHAP Or R-ICE Chemotherapy Included In The Coral Study

Autoři: M.D. Eric Van den Neste, Ph.D.; MD Christian Gisselbrecht; MD Norbert Schmitz; M.D. Nicolas Mounier, Ph.D.; Devinder S Gill, MB ChB, MRCP (UK), FRCPath (Lond); David Linch, FMedSci; Prof. MUDr. Marek Trněný, CSc.; MD Noel-Jean Milpied, Ph.D.; Prof. M.D. John Radford; Nicolas Ketterer; MD Ofer Shpilberg, MPH; M.D. Ulrich Dührsen (Duehrsen); Prof. Dr. David Ma; M.D. Josette Briere; M.D. Catherine Thieblemont, Ph.D.; MD Gilles Andre Salles, PhD; M.D. Craig H Moskowitz; M.D. Bertram Glass, PhD
Číslo abstraktu: 764
Kategorie: Maligní lymfomy a leukémie

731. Clinical Allogeneic and Autologous Transplantation - Results: Poster I

Autologous Hematopoietic Stem Cell Transplantation In Neuromyelitis Optica: A Retrospective Study Of The EBMT Autoimmune Diseases Working Party In Collaboration With The University Of Sao Paulo, Ribeirao Preto, Brazil

Autoři: M.D. Raffaella Greco; M.D. Attilio Bondanza, Ph.D.; Manuela Badoglio; MD Myriam Labopin, MS; M.D. Maria Carolina Oliveira; M.D. Gian Luigi Mancardi ; RN Simona Minguzzi; M.D. Joachim Burman; M.D. Fredrik Piehl, Ph.D.; M.D. Hans Gustaf Hagglund, Ph.D.; MUDr. Eva Krasulová, Ph.D.; M.D. Giancarlo Comi; MD Fabio Ciceri; MD Dominique Farge
Číslo abstraktu: 2125
Kategorie: Maligní lymfomy a leukémie

Survival Outcomes Of Very Young (<40 years) Myeloma Patients

Autoři: MUDr. Utkarsh Painuly; M.D. Shivlal Pandey; M.D. Shaji Kumar; M.D. Robert A. Kyle, MACP; M.D. Martha Q. Lacy; M.D. Morie Gertz, MACP; Prof. Dr. S. Vincent Rajkumar; M.D. Suzanne R. Hayman; M.D. Francis K. Buadi; M.D. David Dingli, Ph.D.; M.D. Stephen J. Russell, Ph.D.; M.D. John A. Lust, Ph.D.; M.D. Arleigh McCurdy; M.D. Angela Dispenzieri; M.D. Prashant Kapoor
Číslo abstraktu: 2136
Kategorie: Mnohočetný myelom

Allogeneic Hematopoietic Cell Transplantation Is Effective In Patients With Advanced Systemic Mastocytosis: A Multicenter Retrospective Analysis

Autoři: Dr. Celalettin Ustun, M.D.; Prof. Dr. Andreas Reiter, M.D.; Bart L. Scott, M.D.; Ryotaro Nakamura, M.D.; Damaj Gandhi; Sebastian Kreil, M.D.; Ryan Shanley; Dr. William J. Hogan, M.D., MBBCh; Dr. Miguel-Angel Perales, M.D.; Dr. Tsiporah B. Shore, M.D.; Herrad Baurmann, M.D.; Prof. Dr. Robert K. Stuart, M.D.; Dr. Bernd Gruhn; prof. MUDr. Michael Doubek, Ph.D.; Dr. Jack W. Hsu, M.D.; Dr. Eleni Tholouli; Tanja Gromke, M.D.; Dr. Lucy A. Godley, M.D., Ph.D.; Livio Pagano, M.D.; Dr. Andrew Gilman, M.D.; Dr. Eva Maria Wagner; Dr. Tor Shwayder, M.D.; Prof. Dr. Martin Bornhaeuser (Bornhäuser); Dr. Esperanza B. Papadopoulos, M.D.; Alexandra Boehm, M.D.; Dr. Gregory M. Vercellotti, M.D.; Dr. Maria Theresa Van Lint; Dr. Christoph Schmid; Dr. Werner Rabitsch, M.D.; Vinod Pullarkat, M.D.; Dr. A. John Barrett, M.D.; Prof. Olivier Hermine, M.D., PhD; M.D. Hans Gustaf Hagglund, Ph.D.; Wolfgang R. Sperr, M.D.; Dr. Uday R. Popat, M.D.; Dr. Steven M. Devine, M.D.; Joachim Deeg, M.D.; Dr. Daniel J. Weisdorf, M.D.; Dr. Cem Akin, M.D.; Prof. Dr. Peter Valent
Číslo abstraktu: 2145
Kategorie: Maligní lymfomy a leukémie

901. Health Services and Outcomes Research: Poster I

No Major Complications In Children After Stem Cell Donation At One Year Follow-Up: EBMT Pediatric Diseases Working Party Study

Autoři: M.D. Jan Styczynski, Ph.D.; M.D. Lidia Gil, Ph.D.; M.D. Franca Fagioli; M.D. Sarah Marktel; M.D. Adriana Balduzzi; Ing. Lenka Janečková; MD Karoline Ehlert; M.D. Jean-Hugues Dalle, Ph.D.; M.D. Jacek Wachowiak, Ph.D.; Maurizio Miano; MD Chiara Messina; M.D. Miguel A. Diaz; Isabel Badell; Prof. Dr.med. Peter Dreger; M.D. Giorgio Dini; MD Christina Peters, Ph.D.
Číslo abstraktu: 1725
Kategorie: Nádory dětského a adolescentního věku