2012 54th ASH Annual Meeting - účast ČR

101. Red Cells and Erythropoiesis, Structure and Function, Metabolism and Survival, Excluding Iron: Poster II

Novel Homozygous VHL Mutation in Exon 2 (413C>T:P138L) Is Associated with Congenital Polycythemia, Elevated Level of RUNX1/AML1 Transcript, but Not with the Cancer

Autoři: Ing. Lucie Piterková; MD Felipe R. Lorenzo V, PhD; MPharm. Hari Vankalayapati, PhD; MD Richard A. Drachtman; MD Josef T. Prchal
Číslo abstraktu: 2081
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

102. Regulation of Iron Metabolism: Poster I

Divalent Metal Transporter 1 (DMT1) Regulates EPO Receptor Gene Expression Via GATA-1

Autoři: Mgr. Pavel Burda, Ph.D.; Mgr. Nikola Čuřík, Ph.D.; Mgr. Monika Horváthová, Ph.D.; Doc.RNDr. Vladimír Divoký, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 0991
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

201. Granulocytes, Monocytes and Macrophages: Myeloid Cell Development and Function

Skewing of the T Cell Receptor Gene Repertoire and Public Clonotypes in Cytotoxic T Cells of Patients with Chronic Idiopathic Neutropenia: A Role for Antigen Selection in Disease Development

Autoři: Evangelia Stalika; Nichalis Spanoudakis; Dr. Nikos Darzentas, PhD; Maria Karypidou; Dr. Achilles Anagnostopoulos; Semeli Mastrodimou; MD Kostas Stamatopoulos; Prof. MD Helen A. Papadaki, PhD
Číslo abstraktu: 0831
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

311. Disorders of Platelet Number or Function: Poster III

Romiplostim for the Treatment of Adults with Primary Immune Thrombocytopenia (ITP) in Routine Clinical Practice – Interim Results From a Large, European, Observational Study

Autoři: MD Dominik Selleslag; MD Ann Janssens; Prof. MD Hans Wadenvik; MD Michael Steurer; Dr. Philippe Quittet; Georgia Kaiafa; doc. MUDr. Tomáš Kozák, Ph.D., MBA; Prof. MD Helen A. Papadaki, PhD; MD Jean-François Viallard, PhD; Kerry Dillingham, MSc; Georg Kreuzbauer
Číslo abstraktu: 3316
Kategorie: Myeloproliferativní nemoci

603. Oncogenes and Tumor Suppressors III

PU.1 and p53 Double Mutant Mice Develop Aggressive AML with Dysplastic Features

Autoři: Mgr. Petra Vlčková (Bašová); RNDr. Ing. Bc. Libor Staněk, PCTM; Mgr. Pavel Burda, Ph.D.; Mgr. Karina Vargová, Ph.D.; Bc. Filipp Savvulidi; Mgr. Martina Kapalová; MD Ulrich Steidl, PhD; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 0769
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

603. Oncogenes and Tumor Suppressors: Poster I

Dynamics and Evolution of the Preleukemic Clone in Slow Onset Leukemias

Autoři: MUDr. Olga Zimmermannová; Prof. MUDr. Ondřej Hrušák, Ph.D.; MUDr. Eva Froňková, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; MUDr. Ester Mejstříková, Ph.D.; Ing. Kateřina Mužíková; Doc.RNDr. Zuzana Zemanová, CSc.; Mgr. Eva Malinová; prof. MUDr. Jan Starý, DrSc.; prof. MUDr. Jan Zuna, Ph.D.
Číslo abstraktu: 1306
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

604. Molecular Pharmacology, Drug Resistance

Ultra-Deep Sequencing of the Bcr-Abl Kinase Domain Allows Earlier Detection and More Accurate Characterization of Resistant Subclones in Philadelphia-Positive Acute Lymphoblastic Leukemia Patients Receiving Tyrosine Kinase Inhibitor-Based Therapies

Autoři: Simona Soverini; Caterina De Benedittis; Mgr. Kateřina Machová (Poláková), Ph.D.; Ing. Adéla Benešová (Broučková), Ph.D.; M.D. Cristina Papayannidis; Paola Bresciani; Valeria Coluccio; Ilaria Iacobucci, PhD; Claudia Venturi; Mario Luppi; Emanuela Ottaviani; Federica Cattina; Robert (Robin) Foa (Foà); MD Antonella Vitale; Prof. Domenico Russo; MD Michele Baccarani; Prof.MD Giovanni Martinelli
Číslo abstraktu: 0284

L-Asparaginase Strongly Affects Bioenergetics in Leukemic Cells

Autoři: Mgr. Ivana Heřmanová; Mgr. Karel Vališ, Ph.D.; Mgr. Karel Fišer, Ph.D.; Mgr. Hana Nůsková; Prof.MUDr. Jan Trka, Ph.D.; Mgr. Júlia Starková, Ph.D.
Číslo abstraktu: 0779
Kategorie: Maligní lymfomy a leukémie

Inhibition of Chk1 Kinase Sensitizes Leukemia and Lymphoma Cell Lines with TP53 Mutations to Chemotherapy

Autoři: Mgr. Jana Zemanová; RNDr. Ludmila Šebejová; Mgr. Ondřej Hylse; Mgr. Kamil Paruch, Ph.D.; Mgr. Šárka Pavlová, PhD; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.; Doc. MUDr. Martin Trbušek, PhD
Číslo abstraktu: 2460
Kategorie: Maligní lymfomy a leukémie; Nádorová biologie/imunologie/genetika a buněčná terapie

611. Leukemias - Biology, Cytogenetics and Molecular Markers in Diagnosis and Prognosis

NUP98/JARID1A Is a New Recurrent Genetic Abnormality in Pediatric Acute Megakaryoblastic Leukemia with a Distinct HOX-Gene Expression Pattern

Autoři: MD Jasmijn D.E. de Rooij; MD Marry M. van den Heuvel-Eibrink, PhD; MD Iris H.I.M. Hollink, PhD; Susan T.C.J.M. Arentsen-Peters; H.Berna Beverloo, PhD; Janneke F. van Galen; MD Andre Baruchel, PhD; Prof.MUDr. Jan Trka, Ph.D.; MD Dirk Reinhardt, PhD; Edwin Sonneveld, PhD; Martin Zimmermann, Ph.D.; Prof. Todd Allen Alonzo, PhD; Prof. MD Rob Pieters, PhD; MD Soheil Meshinchi, PhD; MD Christian Michel Zwaan, PhD
Číslo abstraktu: 0537
Kategorie: Maligní lymfomy a leukémie

Epigenetic Changes in CEBPα Gene and Xenotransplantation Model of B Cell Precursor Acute Lymphoblastic Leukemia Switching to Monocytoid Lineage During the Early Phase of the Treatment

Autoři: MUDr. Lucie Slámová; Mgr. Júlia Starková, Ph.D.; Beat C. Bornhauser, PhD; MUDr. Eva Froňková, Ph.D.; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Bc. Leona Rezková Řezníčková; MUDr. Jana Volejníková; MUDr. Elena Vodičková; MD Frederik W van Delft, PhD; Doc.RNDr. Zuzana Zemanová, CSc.; MD Gunnar Cario; prof. MUDr. Tomáš Kalina, Ph.D.; Mgr. Karel Fišer, Ph.D.; MD Maria E. Figueroa; Prof. MD Michael Dworzak; prof. MUDr. Jan Zuna, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Starý, DrSc.; Prof. MUDr. Ondřej Hrušák, Ph.D.; MD Jean-Pierre Bourquin, PhD; MUDr. Ester Mejstříková, Ph.D.
Číslo abstraktu: 0876
Kategorie: Maligní lymfomy a leukémie

Ultradeep-Amplicon Pyrosequencing for Mutation Detection in the Kinase Domain of BCR-ABL Revealed Artificial Low-Level Variants That Need to Be Avoided for Relevant Mutational Data Interpretation

Autoři: Ing. Adéla Benešová (Broučková), Ph.D.; Simona Soverini; Caterina De Benedittis; MUDr. Hana Klamová, CSc.; MUDr. Mgr. Cyril Šálek, Ph.D.; Prof. MUDr. Marek Trněný, CSc.; MD Michele Baccarani; Prof.MD Giovanni Martinelli; Mgr. Kateřina Machová (Poláková), Ph.D.
Číslo abstraktu: 1396
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

The Interlaboratory Robustness of Next-Generation Sequencing (IRON) Study Phase II: Deep-Sequencing Analyses of Hematological Malignancies Performed by an International Network Involving 26 Laboratories

Autoři: Dr. Alexander Kohlmann, PhD; Prof.MD Giovanni Martinelli; Wolf-Karsten Hofmann; Dr. Geertruy (Gertruuy) Te Kronnie, PhD; MD Sabina Chiaretti, PhD; Prof. Claude Preudhomme, MD; MD Enrico Tagliafico; MD Jesus Hernandez; MD Christian Gabriel; Prof. MD Thomas Lion, PhD; MD Peter Vandenberghe (Vandenberge), Ph.D.; Mgr. Kateřina Machová (Poláková), Ph.D.; Marie - Christine Béné; MD Monika Brüggemann (Bruegemann), PhD; Giovanni (Gianni) Cazzaniga, PhD; M.D. Allen Eng Juh Yeoh; MD Soren Lehmann, PhD; MD Thomas Ernst; Elisabeth Oppliger Leibundgut, PharmD; prof. MD Ugur Ozbek, PhD.; Prof. Dr. Ken I. Mills, PhD; MD Martin Dugas; M.D. Christian Thiede; Dr. ssa Orietta Spinelli, PhD, BiolSC; MD Letizia Foroni, PhD; Joop H. Jansen, PhD; MD Andreas Hochhaus; MD Torsten Haferlach
Číslo abstraktu: 1399
Kategorie: Maligní lymfomy a leukémie

Proteomic Exploration of the Cell Surface Landscape Reveals New Leukemia Associated Features

Autoři: MD Jean-Pierre Bourquin, PhD; MSc Paulina Mirkowska; MUDr. Ester Mejstříková, Ph.D.; MUDr. Lucie Slámová; MD Tomasz Szczepanski, PhD; Lukasz Sedek, PhD; Maike Schmitz, PhD; Vincent H.J. Van der Velden, PhD; Andreas Hofmann, PhD; MD Gunnar Cario; MD Martin Stanulla, MSc; Beat C. Bornhauser, PhD; Bernd Wollscheid, PhD
Číslo abstraktu: 2506
Kategorie: Maligní lymfomy a leukémie

Low Levels of Mir-151-5p and Mir-451 Predict Relapse in Pediatric B-Lineage Acute Lymphoblastic Leukemia

Autoři: Smadar Avigad, PhD; Iedan R.N. Verly; MD Gertjan (J.L.) Kaspers, PhD; Jacqueline Cloos, Ph.D.; Anat Ohali, PhD; Michal Hameiri-Grossman; MUDr. Eva Froňková, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Drorit Luria, PhD; Yona Kodman; Hadar Mirsky; Dafna Gaash; Marta Jeison, PhD; MD Galia Avrahami; MD Sarah Elitzur; MD Gil Gilad; MD Batia Stark; Prof. M.D. Isaac Yaniv
Číslo abstraktu: 2507
Kategorie: Maligní lymfomy a leukémie

Pediatric Acute Myeloid Leukemia with t(8;16)(p11;p13): A Distinct Clinical and Biological Entity. Results of a Collaborative Study by the International Berlin-Frankfurt-Münster AML Study Group

Autoři: MD Eva A Coenen; MD Christian Michel Zwaan, PhD; PhD Christine J. Harrison, FRCPath; Prof. Dr. Oskar A. Haas; MD Valerie de Haas, Ph.D.; prof. MUDr. Vladimír Mihál, CSc.; MD Barbara De Moerloose; Marta Jeison, PhD; MD Jeffrey Rubnitz, PhD; MD Daisuke Tomizawa; MD Donna Johnston, FRCP; Prof. Todd Allen Alonzo, PhD; Prof. MD Henrik Hasle; MD Dirk Reinhardt, PhD; MD Anne Auvrignon; Prof. MD Michael Dworzak; Prof. MD Andrea Pession; Vincent H.J. Van der Velden, PhD; John Swansburry; MD Kit Fai Wong; MD Kiminori Terui; MD Sureyya Savasan; M. Winstanley; G. Vaitkeviciene; Prof. MD Rob Pieters, PhD; Martin Zimmermann, Ph.D.; MD Marry M. van den Heuvel-Eibrink, PhD
Číslo abstraktu: 2516
Kategorie: Maligní lymfomy a leukémie

The Musashi 2 mRNA Expression in the Course of CML

Autoři: Mgr. Sylvie Nádvorniková; RNDr. Markéta Žáčková, Ph.D.; Mgr. Tereza Lopotová; MUDr. Hana Klamová, CSc.; RNDr. Jana Moravcová, CSc.
Číslo abstraktu: 2552
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

612. Acute Lymphoblastic Leukemia - Pathophysiology & Clinical Studies

Role of MRD in Ph+ Pediatric Acute Lymphoblastic Leukemia Patients Treated with and without Tirosine Kinase Inhibitor in the Esphall Study

Autoři: Giovanni (Gianni) Cazzaniga, PhD; MD Martin Schrappe; Paola de Lorenzo, PhD; Anders Castor; Giovanna Lucchini; MD Virginie Gandemer; Prof. MD Rob Pieters, PhD; prof. MUDr. Jan Starý, DrSc.; MD Gabriele Escherich; Dr. Jeremy Hancock, Ph.D.; Maurizio Arico; Silja Röttgers; Prof. Vaskar Saha, PhD, FRCP, FRCPath; MD Andrea Biondi; Prof. Maria Grazia Valsecchi, PhD
Číslo abstraktu: 1467
Kategorie: Maligní lymfomy a leukémie

613. Acute Myeloid Leukemia - Pathophysiology & Clinical Studies

Clinical Impact of Additional Cytogenetic Aberrations and Treatment in Pediatric t(8;21)-Positive AML: Results from an International Retrospective I-BFM-SG Study

Autoři: Ardine Reedijk, MSc; MD Gertjan (J.L.) Kaspers, PhD; Marta Fiocco, PhD; Prof. MD Andrea Pession; MD Dirk Reinhardt, PhD; Martin Zimmermann, Ph.D.; Prof. MD Michael Dworzak; Prof. Todd Allen Alonzo, PhD; MD Donna Johnston, FRCP; MUDr. Michal Zápotocký; MD Barbara De Moerloose; Fynn Finita; MD Vincent Lee, PhD; MD Takashi Taga; MD Akio Tawa, PhD; MD Anne Auvrignon; Bernward Zeller; MD Carmen Salgado, PhD; MD Walentyna Balwierz, PhD; Alexander Popa; MD Jeffrey Rubnitz, PhD; H.Berna Beverloo, PhD; PhD Christine J. Harrison, FRCPath; Brenda Gibson
Číslo abstraktu: 0884
Kategorie: Maligní lymfomy a leukémie

High Frequency of GATA1 Mutations in Childhood Non-Down Syndrome Acute Megakaryoblastic Leukemia

Autoři: Katarina Reinhardt, PhD; MD Christian Michel Zwaan, PhD; Prof. MD Michael Dworzak; MD Jasmijn D.E. de Rooij; MD Gertjan (J.L.) Kaspers, PhD; Thomas Lehrnbecher; Prof. MD Henrik Hasle; Toralf Bernig; Jean-Michel Cavuela; MUDr. Alexandra Kolenová, Ph.D.; Jochen Harbott; MD Jean-Pierre Bourquin, PhD; prof. MUDr. Jan Starý, DrSc.; MD Ursula Creutzig, PhD; MD Dirk Reinhardt, PhD
Číslo abstraktu: 0888
Kategorie: Maligní lymfomy a leukémie

Acute Erythroleukemia Morphology Does Not Confer an Unfavourable Prognosis in Itself. Results of a Subgroup Analysis of the Prospective Randomized AML96-, AML2003 and AML60+ Studies of the Study Alliance Leukemia (SAL)

Autoři: MD Stefani Parmentier; Michael Kramer; Katharina Koch; Brigitte Mohr, PhD; Christian Klesse; M.D. Christian Thiede; MD Christoph Röllig; MD Mathias Hänel; MD Norbert Schmitz; Dr. Kerstin Schäfer-Eckart; Walter E. Aulitzky; MD Wolfgang E. Berdel; Prof. MD Hubert Serve; Stefan W. Krause; prof. MUDr. Jiří Mayer, CSc.; Prof. Dr. Martin Bornhaeuser (Bornhäuser); MD Gerhard Ehninger; MD Marcus Schaich
Číslo abstraktu: 1481
Kategorie: Maligní lymfomy a leukémie

Telomere Length and Telomerase Complex Mutations in Pediatric Acute Myeloid Leukemia

Autoři: Anna M. Aalbers; Rodrigo T. Calado; Neal S. Young; MD Christian Michel Zwaan, PhD; Colin O. Wu; Sachiko Kajigaya, PhD; MD Eva A Coenen; MD Andre Baruchel, PhD; Karin Geleijns; MD Valerie de Haas, Ph.D.; MD Gertjan (J.L.) Kaspers, PhD; Taco W. Kuijpers; MD Dirk Reinhardt, PhD; Prof.MUDr. Jan Trka, Ph.D.; Martin Zimmermann, Ph.D.; Prof. MD Rob Pieters, PhD; Vincent H.J. Van der Velden, PhD; MD Marry M. van den Heuvel-Eibrink, PhD
Číslo abstraktu: 1482
Kategorie: Maligní lymfomy a leukémie

615. Acute Myeloid Leukemia - Therapy, excluding Transplantation

Tracking the Extramedullary PML-RARα-Positive Cell Reservoirs in a Preclinical Model of APL: Biomarker of Long-Term Drug Efficacy

Autoři: Kateřina Pokorná, PhD; BSc Carole Le Pogam; Martine Chopin; PharmD Bruno Cassinat, PhD; MD Pierre Fenaux, PhD; MD Christine Chomienne, PhD; Rose Ann Padua, PhD; Marika Pla, PhD
Číslo abstraktu: 1510
Kategorie: Maligní lymfomy a leukémie

Lithium Treatment Potentiates Both in Vitro and in Vivo Retinoic Acid Efficacy in APL

Autoři: Fabien Zassadowski, PhD; Kateřina Pokorná, PhD; Nicolas Ferre; PharmDr. Laura Llopis; Oussama Chourbagi, PhD; PharmDr. Joel Poupon; Martine Chopin; MD Pierre Fenaux, PhD; Rose Ann Padua, PhD; Marika Pla, PhD; MD Christine Chomienne, PhD; PharmD Bruno Cassinat, PhD
Číslo abstraktu: 2614
Kategorie: Maligní lymfomy a leukémie

Additional Prognostic Impact of Specific Sites of Extramedullary Leukemia in Pediatric AML with MLL-Rearrangements but Not in Core-Binding Factor (CBF) AML

Autoři: MD Ursula Creutzig, PhD; Martin Zimmermann, Ph.D.; Prof. MD Michael Dworzak; MD Jean-Pierre Bourquin, PhD; MD Christine von Neuhoff; MD Annette Sander; prof. MUDr. Jan Starý, DrSc.; MD Dirk Reinhardt, PhD
Číslo abstraktu: 2621
Kategorie: Maligní lymfomy a leukémie

Multivariate and Subgroup Analyses of a Multinational Phase III Trial of Decitabine in Older Patients with Newly Diagnosed Acute Myeloid Leukemia

Autoři: prof. MUDr. Jiří Mayer, CSc.; MD Christopher Arthur; MD Jacques Delaunay; MD Grzegorz Mazur, PhD; MD Xavier G. Thomas; MD Agnieszka Wierzbowska, PhD; MD Mark M. Jones; MD Erhan Berrak; M.D. Hagop M. Kantarjian
Číslo abstraktu: 3618
Kategorie: Maligní lymfomy a leukémie

622. Non-Hodgkin Lymphoma - Biology, excluding Therapy

High Expression of Activation-Induced Cytidine Deaminase and in Vivo Class Switch Recombination in Mantle Cell Lymphoma: Further Support for Antigen Involvement in Lymphomagenesis

Autoři: Aliki Xochelli; Fotini Marantidou; Evangelia Stalika; Laurent Sutton; Alba Navarro (Lopez), Ph.D.; Mgr. Jana Šupíková; Kyriakos Karypidis; Maria Chatzouli; Myriam Boudjogra; Christer Sundstrom; Mgr. Hana Skuhrová Francová; Dr. Achilles Anagnostopoulos; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Theodora Papadaki, Ph.D.; Dr. Christianne Pott, PhD; MD Frederic Davi, PhD; M.D. Elias Campo, Ph.D.; Prof. MD Richard Rosenquist (Brandell), PhD; MD Chrysoula Belessi; MD Kostas Stamatopoulos
Číslo abstraktu: 1538
Kategorie: Maligní lymfomy a leukémie

Prognostic Impact of Fc Gamma-Receptor Polymorphisms and Efficacy of Rituximab in Children and Adolescents with Mature Aggressive B-NHL

Autoři: MD Birgit Burkhardt, PhD; Deniz Yavuz; Martin Zimmermann, Ph.D.; Jutta Schieferstein; as.MUDr. Edita Kabíčková, Ph.D.; MD Andische Attarbaschi, PhD; MD Jasmin Lisfeld; Bettina R. Bonn, PhD; MD Alfred Reiter; Christine Damm-Welk, PhD
Číslo abstraktu: 1547
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Clonal Selection in the Ontogeny and Evolution of Splenic Marginal Zone Lymphoma Confirming the Existence of Distinct Molecular Subtypes

Autoři: Vasilis Bikos; Evangelia Stalika; Maria Karypidou; Panagiotis Baliakas; Zadie Davis; Patricia Algara; George Kanellis; Antonis Dagklis; Alexandra Traverse-Glehen; Sarah Hockley; MD Manuela Mollejo, Ph.D.; Athanasios Tsaftaris; Dr. Achilles Anagnostopoulos; MD Maurilio Ponzoni; MD Francoise Berger; Pascale Felman; David Gonzalez, PhD; Estella Matutes; MD Miguel Angel Piris; MD Theodora Papadaki, Ph.D.; M.D. Paolo Ghia, Ph.D.; Prof. David Graham Oscier; MD Chrysoula Belessi; Dr. Nikos Darzentas, PhD; MD Kostas Stamatopoulos
Číslo abstraktu: 1556
Kategorie: Maligní lymfomy a leukémie

Absence of Prognostic Impact Associated with the Use of Statins in Patients with Follicular Lymphoma in the Rituximab Era: An Exploratory Analysis From the PRIMA Study

Autoři: MD Emmanuel Bachy; Prof. John Francis Seymour, MD, PhD, MBBS, FRACP; MD Pierre Feugier, PhD; MD Fritz C. Offner, PhD; MD Dolores Caballero; MD Reda Bouabdallah; MD Lars Moller Pedersen, PhD; MD Pauline Brice; MUDr. David Belada, Ph.D.; MD Luc Xerri, PhD; MD Gilles Andre Salles, PhD
Číslo abstraktu: 2649
Kategorie: Maligní lymfomy a leukémie

Number of PD-1+/CD8+ Cells in Peripheral Blood of Patients with Lymphoma Reflects Tumor Burden, Lymphoma Subtype, Disease Phase and Is Significantly Higher Compared to Healthy Volunteers

Autoři: MUDr. Vít Procházka, Ph.D.; RNDr. Martin Novák; RNDr. Zuzana Pikalová; doc. MUDr. Tomáš Papajík, CSc.; prof. MUDr. Karel Indrák, DrSc.; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 2670
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Programmed Death-1 Ligand Is Uniformly Expressed On Primary Mediastinal Diffuse Large B-Cell Lymphoma Cells with No Influence On Patient Survival

Autoři: MUDr. Vít Procházka, Ph.D.; doc. MUDr. Tomáš Papajík, CSc.; MUDr. Patrik Flodr; MUDr. Pavla Látalová; as. MUDr. Zuzana Prouzová; Mgr. Radka Nedomová; Prof. RNDr. Mgr. Marie Jarošová, CSc.; Doc.RNDr. Vladimír Divoký, Ph.D.; prof. MUDr. Karel Indrák, DrSc.
Číslo abstraktu: 2671
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

CD31/PECAM-1 Is Overexpressed On Mantle-Cell Lymphoma (MCL) Primary Cells and Positively Regulates Engraftment and Growth of MCL Cell Lines in Immunodeficient Mice

Autoři: MUDr. Jan Molinský; MUDr. Magdalena Klánová; MUDr. Bokang Calvin Maswabi; MUDr. Josef Karban, CSc.; MUDr. Martin Špaček, Ph.D.; Prof. MUDr. Marek Trněný, CSc.; Prof. MUDr. Emanuel Nečas, DrSc.; Doc.MUDr. Jan Živný, Ph.D.; MUDr. Pavel Klener jr, Ph.D.
Číslo abstraktu: 2681
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

623. Lymphoma - Chemotherapy, excluding Pre-Clinical Models

Treatment of Stage I-II A Non-Bulky Hodgkin’s Lymphoma (HL): An Individual Patient-Data Comparison of German Hodgkin Study Group (GHSG) HD10 and HD11 Combined-Modality Therapy (CMT) and NCIC Clinical Trials Group (NCIC CTG) HD.6 ABVD Alone

Autoři: Annette E. Hay, MBChB; MD Beate Klimm; Bingshu E. Chen, PhD; Helen Goergen; MD Lois E. Shepherd; MD Michael Fuchs; MD Mary Gospodarowicz; MD Peter Borchmann, PhD; MD Joseph M. Connors; MUDr. Jana Marková; MD Michael Crump, FRCPC; MD Andreas Lohri; MD Jane N. Winter, Northwestern University Feinberg School of Medicine; Bernd Dörken (Doerken); MD Robert G. Pearcey; MD Volker Diehl; MD Sandra J. Horning; MD Hans Theodor Eich; Prof. MD Andreas Engert; MD Ralph M. Meyer
Číslo abstraktu: 0548
Kategorie: Maligní lymfomy a leukémie

Prognostic Relevance of Dose-Density of DHAP-Reinduction Therapy in Relapsed HL: An Analysis of the German Hodgkin-Study Group (GHSG)

Autoři: MD Stephanie Sasse; Medical Student Magdalena Alram; Horst Mueller, PhD; MUDr. Lenka Volková; Bernd Metzner; Prof. Dr. med. Hartmut Döhner (Doehner); MD Thomas Fischer; Vladan Vucinic; MD Norbert Schmitz; Dr. Kerstin Schäfer-Eckart; MD John M. Raemaekers, PhD; MD Oliver Schmalz; MD Bastian von Tresckow; Prof. MD Andreas Engert; MD Peter Borchmann, PhD
Číslo abstraktu: 0552
Kategorie: Maligní lymfomy a leukémie

Primary Mediastinal B Cell Lymphoma Treated with CHOP-Like Chemotherapy with or without Rituximab: 5-Year Results of the Mabthera International Trial Group (MInT) Study

Autoři: MD Mathias Witzens-Harig; Prof.MD Anthony D. Ho, PhD, FRCP; Evelyn Kuhnt; Prof. MUDr. Marek Trněný, CSc.; MD Michael Rieger; MD Anders Österborg, PhD; Ruth Pettengel, MBchB, FRACP, PhD; MD Robert Stevens; Devinder S Gill, MB ChB, MRCP (UK), FRCPath (Lond); MD Jan Andrzej Walewski, Ph.D.; Markus Loeffler; MD Michael Pfreundschuh
Číslo abstraktu: 1612
Kategorie: Maligní lymfomy a leukémie

624. Lymphoma - Therapy with Biologic Agents, excluding Pre-Clinical Models

First Interim Efficacy and Safety Analysis of an International Phase III Randomized Trial in Newly Diagnosed Systemic Peripheral T-Cell Lymphoma Treated with Chemotherapy with or without Alemtuzumab and Consolidated by High Dose Therapy

Autoři: MD Francesco Annibale d'Amore, SMSci; prof. Sirpa Leppä; M.D. Maria Gomes da Silva, Ph.D.; Thomas Relander; Peter de Nully Brown; Eckhart Weidmann; Grete Fossum Lauritzsen; Antonio Pezzutto; Achiel Van Hoof; Michel Van Gelder; MD Jeanette K Doorduijn, PhD; MD Ka Lung Wu, PhD; Johanna C. Kluin-Nelemans; Pieternella J. Lugtenburg; MUDr. Milada Jankovská; Mats Merup; Unn-Merete Fagerli; MD Jan Andrzej Walewski, Ph.D.; Hans Hagberg; Jose Mario Mariz; Per Boye Hansen; M.D. Thomas Nösslinger; MD Ann Janssens; Lena Brandefors; Hilde Demuynck; Martyn Ronald Schaafsma; Ilse Christiansen; MUDr. David Šálek, Ph.D.; Sirkku Jyrkkiö; MUDr. Vít Procházka, Ph.D.; Jose Zijlstra, MD; L. Böhmer; MD Richard Greil, Ph.D.; Wendy Stevens; Rob Fijnheer; Marinus van Marwijk Kooy; Matthias Grube; Georg Hopfinger; M.D. Eric Van den Neste, Ph.D.; Esa Jantunen; Lorenz Trümper; Gerald Wulf; Bettina Altmann; Marita Ziepert; Markus Loeffler; Helle Toldbod
Číslo abstraktu: 0057
Kategorie: Maligní lymfomy a leukémie

The Addition of Bevacizumab to Standard Therapy with R-CHOP in Patients with Previously Untreated Diffuse Large B-Cell Lymphoma Is Associated with an Increased Rate of Cardiac Adverse Events: Final Analysis of Safety and Efficacy Outcomes From the...

Autoři: Prof. John Francis Seymour, MD, PhD, MBBS, FRACP; MD Michael Pfreundschuh; MD Bertrand Coiffier; Prof. MUDr. Marek Trněný, CSc.; Laurie H. Sehn; Eva Csinady
Číslo abstraktu: 0058
Kategorie: Maligní lymfomy a leukémie

Ofatumumab (OFA) in Combination with CHOP for Previously Untreated Follicular Lymphoma: Follow-up Results

Autoři: MD Myron Stefan Czuczman; MD Georg Hess; Ole Gadeberg; MD Lars Moller Pedersen, PhD; Per Hansen; MUDr. David Belada, Ph.D.; MD Stephanie A. Gregory; MD Brad Pohlman; prof. MUDr. Jiří Mayer, CSc.; MUDr. Robert Pytlík, Ph.D.; Lorenz Trümper; MD Andreas Viardot; MD Ira (V.) Gupta; MD Thomas S. Lin, PhD; Paul D. Winter; Nancy Goldstein; Roxanne C Jewell, PhD; MD Steen Lisby, DMSc
Číslo abstraktu: 1632
Kategorie: Maligní lymfomy a leukémie

Final Results of the BP22333 Study Demonstrate Non-Inferior Pharmacokinetics (PK) and Safety of Subcutaneous (SC) Administration of Rituximab Compared with Intravenous (IV) Administration As Maintenance Therapy in Patients with Follicular Lymphoma (F

Autoři: MD Antonio Salar; MD Irit Avivi; MD Jean-Francois Larouche; Doc.MUDr. Andrea Janíková, Ph.D.; Juliana Pereira, PhD; Mike Brewster; Olivier Catalani; Christine McIntyre; Pakeeza Sayyed; Andrew Haynes
Číslo abstraktu: 1641
Kategorie: Maligní lymfomy a leukémie

Relative Reduction of Residual Tumor Improves Outcome Prediction of PET After Effective Chemotherapy for Patients with Advanced Stage Hodgkin Lymphoma

Autoři: Prof. MD Andreas Engert; MD Carsten Kobe; Heinz Haverkamp; Georg Kuhnert; MUDr. Jana Marková; MD Andreas Lohri; MD Susanne Klutmann; Prof. Dr. med. Holger Amthauer; MD Volker Diehl; MD Peter Borchmann, PhD; MD Markus Dietlein
Číslo abstraktu: 3684
Kategorie: Maligní lymfomy a leukémie

625. Lymphoma - Pre-Clinical - Chemotherapy and Biologic Agents

Ublituximab (TGTX-1101), A Novel Anti-CD20 Monoclonal Antibody (mAb), Demonstrates Activity in Rituximab-Sensitive and Rituximab–resistant B Non-Hodgkin Lymphoma (B-NHL) Pre-Clinical In vitro and in Vivo models

Autoři: John Miller; MD Matthew John Barth; BSc Cory Mavis, MSc; Ping-Chiao Tsai, PhD; MUDr. Pavel Klener jr, Ph.D.; MD Francisco J. Hernandez-Ilizaliturri; MD Myron Stefan Czuczman
Číslo abstraktu: 2756
Kategorie: Maligní lymfomy a leukémie

Ofatumumab (OFA) Is a Novel Anti-CD20 Monoclonal Antibody (mAb) with Improved Anti-Tumor Activity in Vitro and in Vivo in Mantle Cell Lymphoma (MCL) Pre-Clinical Models

Autoři: MD Matthew John Barth; MD Gopichand Pendurti; Ping-Chiao Tsai, PhD; BSc Cory Mavis, MSc; MUDr. Pavel Klener jr, Ph.D.; MD Myron Stefan Czuczman; MD Francisco J. Hernandez-Ilizaliturri
Číslo abstraktu: 2757
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Mouse Models of Human Mantle Cell Lymphoma for the Study of Disease Biology and for Pre-Clinical Assessment of Experimental Treatment Approaches

Autoři: MUDr. Pavel Klener jr, Ph.D.; MUDr. Magdalena Klánová; MUDr. Tomáš Soukup (1980-), Ph.D.; MUDr. Jan Molinský; Doc.MUDr. Jan Živný, Ph.D.; Prof. MUDr. Marek Trněný, CSc.; MD Francisco J. Hernandez-Ilizaliturri; MD Myron Stefan Czuczman; Prof. MUDr. Emanuel Nečas, DrSc.
Číslo abstraktu: 2759
Kategorie: Maligní lymfomy a leukémie

Evaluation of the Anti-Tumor Activity of MLN4924, A Novel NEDD8 Activating Enzyme Inhibitor, in Pre-Clinical Models of Rituximab Chemotherapy-Sensitive or -Resistant B-Cell Lymphoma

Autoři: Natalie M. Czuczman; MD Matthew John Barth; Richa Dwar; BSc Cory Mavis, MSc; MUDr. Pavel Klener jr, Ph.D.; MD Myron Stefan Czuczman; MD Francisco J. Hernandez-Ilizaliturri
Číslo abstraktu: 2761
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

631. Chronic Myeloid Leukemia - Biology and Pathophysiology, excluding Therapy

Apoptosis in Chronic Myeloid Leukemia Cells Transiently Treated with Imatinib or Dasatinib Is Caused by Residual BCR-ABL Kinase Inhibition

Autoři: Mgr. Pavel Šimara, Ph.D.; Mgr. Stanislav Stejskal; RNDr. Irena Koutná, Ph.D.; Mgr. David Potěšil; Mgr. Lenka Tesařová, PhD; Mgr. Michaela Potěšilová; Doc. RNDr. Zbyněk Zdráhal, Dr.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 1668
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

632. Chronic Myeloid Leukemia - Therapy

Early Response (Molecular and Cytogenetic) and Long-Term Outcomes in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CML-CP): Exploratory Analysis of DASISION 3-Year Data

Autoři: MD Giuseppe Saglio, PhD.; M.D. Hagop M. Kantarjian; MD Neil Shah, PhD; MD Elias J. Jabbour; MD Alfonso Quintas-Cardama; MD Juan Luis Steegmann, PhD; MD Concepción Boqué; MD Charles Chuah; MD Carolina Pavlovsky; prof. MUDr. Jiří Mayer, CSc.; Jon Ukropec, PhD; Mark Wildgust, PhD; MD Andreas Hochhaus
Číslo abstraktu: 1675
Kategorie: Maligní lymfomy a leukémie

Functional Characterization of T- and NK-Cells in Chronic Myeloid Leukemia Patients Treated with Interferon-α Monotherapy

Autoři: MSc Mette Matilda Ilander; Anna Kreutzman, PhD; MUDr. Peter Rohoň; MD Teresa Melo; prof. MUDr. Edgar Faber, CSc.; MD Kimmo Porkka, PhD; MD Jukka Vakkila, PhD; MD Satu Mustjoki, PhD
Číslo abstraktu: 2782
Kategorie: Maligní lymfomy a leukémie

The International Registry for Chronic Myeloid Leukemia (CML) in Children and Adolescents (I-CML-Ped-Study): Objectives and Preliminary Results

Autoři: Frédéric Millot; Prof. MD Meinolf Suttorp, PhD; Joelle Guilhot (Guillhot), PhD; prof. MUDr. Petr Sedláček, CSc.; MD Eveline S.J.M. de Bont, PhD; MD Chi Kong Li, MBBS; Krzysztof Kalwak; Birgitte Lausen; Srdjana Culic; Marie-Françoise Dresse; MD Andrea Biondi; MD Andre Baruchel, PhD
Číslo abstraktu: 3741
Kategorie: Maligní lymfomy a leukémie

Prognostic Factors Identified Via a Cox Proportional Hazard Cure Model Explain Survival Differences After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) in Chronic Myeloid Leukemia (CML) Between Two Consecutive Patient Cohorts

Autoři: Dr. rer. biol. hum. Markus Pfirrmann, M.Sc.; MD Susanne Saussele; MD Andreas Hochhaus; Prof. Dr. Andreas Reiter, M.D.; Ute Berger; Prof. Dr. Dieter K. Hossfeld; Prof. Christoph Nerl; Prof. MD Christof Scheid, Ph.D.; Prof. Dr. Karsten Spiekermann; prof. MUDr. Jiří Mayer, CSc.; Christiane Falge; Dr. Herbert G. Sayer, Ph.D.; Prof. Dr. med. Arnold Ganser; M.D. Dietrich W. Beelen; Helene Baldomero; Urs Schanz; Hermann Heimpel; MD Joerg Hasford; Hans-Jochem Kolb; Alois Gratwohl; Prof. Dr. Rüdiger Hehlmann; The German CML Study Group
Číslo abstraktu: 3748
Kategorie: Maligní lymfomy a leukémie

EUTOS Score Is Also Valid in CML Patients Not Involved in Clinical Studies

Autoři: Dr. rer. biol. hum. Verena Sophia Hoffmann, BSc, M.A.; prof. MUDr. Jiří Mayer, CSc.; MD Anna Turkina, PhD; MD Andrzej Hellmann, Ph.D.; prof. MUDr. Karel Indrák, DrSc.; MD Juan Luis Steegmann, PhD; MD Andrey Zaritsky (Zaritskey); Dr. Adriana Colita; Dipl. Inf. Doris Lindörfer (Lindoerfer); MD Michele Baccarani
Číslo abstraktu: 3759
Kategorie: Maligní lymfomy a leukémie

Dissecting the Complexity of Philadelphia-Positive Mutated Populations by Ultra-Deep Sequencing of the Bcr-Abl Kinase Domain: Biological and Clinical Implications

Autoři: Simona Soverini; Caterina De Benedittis; Mgr. Kateřina Machová (Poláková), Ph.D.; Ing. Adéla Benešová (Broučková), Ph.D.; MD Fausto Castagnetti; M.D. Cristina Papayannidis; Gabriele Gugliotta; Francesca Palandri; MUDr. Hana Klamová, CSc.; Ilaria Iacobucci, PhD; Claudia Venturi; Federica Cattina; Paola Bresciani; Valeria Coluccio; MD Marzia Salvucci; Mario Tiribelli; MD Gianni Binotto; Tamara Intermesoli; Mario Luppi; Maria Teresa Bochicchio; Emanuela Ottaviani; Prof. Domenico Russo; Prof. MD Gianantonio Rosti; MD Michele Baccarani; Prof.MD Giovanni Martinelli
Číslo abstraktu: 692
Kategorie: Maligní lymfomy a leukémie

633. Myelodysplastic Syndromes

Prognostic Relevance of the Kinetics of Worsening of Cytopenias in Lower-Risk MDS: A Substudy From the European Leukemianet Low Risk MDS (EUMDS) Registry

Autoři: Raphael Itzykson; Alexandra Smith; MD Theo de Witte, PhD; Jackie Droste; MD Reinhard Stauder; Dr. Argyris Symeonidis, Ph.D.; MD Eva Hellström-Lindberg; MD Guillermo F Sanz, PhD; prof. MUDr. Jaroslav Čermák, CSc.; Otilia Georgescu; MD Mette Skov-Holm, PhD; MD Ulrich Germing; Marius MacKenzie; MD Odile Beyne Rauzy, PhD; MD Luca Malcovati; MD David Bowen, Ph.D.; MD Pierre Fenaux, PhD
Číslo abstraktu: 0700

Unexpected High Frequency of GATA2 Mutations in Children with Non-Familial MDS and Monosomy 7

Autoři: MD Shinsuke Hirabayashi; MD Brigitte Strahm; Sandra Urbaniak; Axel Karow; Annamaria Cseh; MD Marry M. van den Heuvel-Eibrink, PhD; Selin Aytag; Claudia Wehr; MUDr. Aleš Janda, MSc; prof. MUDr. Jan Starý, DrSc.; Prof. MD Henrik Hasle; Prof. MD Michael Dworzak; MD Markus Schmugge (Schmugge-Liner); Prof. MD Franco Locatelli, PhD; MD Barbara De Moerloose; Albert Catala; Owen Smith; MD Irith Baumann; MD Gudrun Göhring; Prof. MD Brigitte M. Schlegelberger; Prof. MD Charlotte M. Niemeyer, PhD; MD Marcin W. Wlodarski
Číslo abstraktu: 1699
Kategorie: Myelodysplastický syndrom

Molecular Aberrations in 107 Children with Myelodysplastic Syndrome (MDS)

Autoři: MD Andrica de Vries; MD Christian Michel Zwaan, PhD; Joop H. Jansen, PhD; Prof. MD Michael Dworzak; Prof. MD Henrik Hasle; Prof. MD Franco Locatelli, PhD; MD Barbara De Moerloose; Susan T.C.J.M. Arentsen-Peters; MD Valerie de Haas, Ph.D.; MD Sophia Polychronopoulou, Ph.D.; prof. MUDr. Jan Starý, DrSc.; MD Markus Schmugge (Schmugge-Liner); MD Marco Zecca; Owen Smith; Albert Catala; Prof. MD Brigitte M. Schlegelberger; H.Berna Beverloo, PhD; Prof. MD Rob Pieters, PhD; Prof. MD Charlotte M. Niemeyer, PhD; MD Marry M. van den Heuvel-Eibrink, PhD
Číslo abstraktu: 2802

Early Mortality in 1000 Newly Diagnosed MDS Patients with Low- and Intermediate-1 Risk MDS in the European Leukemianet MDS (EUMDS) Registry

Autoři: MD Louise de Swart; Alexandra Smith; MD Pierre Fenaux, PhD; MD Guillermo F Sanz, PhD; MD Eva Hellström-Lindberg; Dr. Argyris Symeonidis, Ph.D.; prof. MUDr. Jaroslav Čermák, CSc.; MD Ulrich Germing; MD Reinhard Stauder; Otilia Georgescu; Marius MacKenzie; MD Luca Malcovati; MD Mette Skov-Holm, PhD; MD Krzysztof Madry, PhD; Sophie Park; Odile Beyne-Rauzy; Jackie Droste; MD David Bowen, Ph.D.; MD Theo de Witte, PhD
Číslo abstraktu: 3830

Transcription Factor CTCF Inhibits Effects of 5-Azacitidine in MDS/AML Cells

Autoři: Mgr. Martina Kapalová; Mgr. Pavel Burda, Ph.D.; Mgr. Karina Vargová, Ph.D.; Bc. Filipp Savvulidi; Mgr. Tomáš Zikmund; Mgr. Nikola Čuřík, Ph.D.; doc. MUDr. Anna Jonášová, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 3848
Kategorie: Myelodysplastický syndrom

635. Myeloproliferative Syndromes - Basic Science

Whole Exome Sequencing of Polycythemia Vera Reveals Novel Recurrent Somatic and Germline Variation

Autoři: Linghua Wang, PhD; Sabina Swierczek, PhD; Ing. Lucie Piterková; Kimberly Hickman; David A. Wheeler, PhD; MD Josef T. Prchal
Číslo abstraktu: 0705
Kategorie: Myeloproliferativní nemoci

Whole Genome Sequencing of Four CD34+-Derived iPSC Polycythemia Vera Clones From a Single Female

Autoři: Lifeng Tian, PhD; Ing. Lucie Piterková; Linghua Wang, PhD; Zhaohui Ye, PhD; Linzhao Cheng; David A. Wheeler, PhD; MD Hakon Hakonarson, PhD; MD Josef T. Prchal
Číslo abstraktu: 1755
Kategorie: Myeloproliferativní nemoci

641. CLL - Biology and Pathophysiology, excluding Therapy

Distinct Profiles of in Vivo Class Switch Recombination in Chronic Lymphocytic Leukemia Subsets with Stereotyped B Cell Receptors, Suggestive of Distinct Modes of Activation by Antigen

Autoři: Aliki Xochelli; Evangelia Stalika; Lesley-Ann Sutton; Vassiliki Douka; Maria Karypidou; Michalis Iskas; Maria Chatzouli; Antonis Dagklis; Dr. Achilles Anagnostopoulos; M.D. Paolo Ghia, Ph.D.; Prof. MD Richard Rosenquist (Brandell), PhD; Dr. Nikos Darzentas, PhD; MD Chrysoula Belessi; MD Kostas Stamatopoulos
Číslo abstraktu: 1777
Kategorie: Maligní lymfomy a leukémie

Assessment of p53 Functionality in Chronic Lymphocytic Leukemia by Different Assays; An Eric-Wide Approach

Autoři: MD Doreen te Raa; RNDr. Jitka Malčíková, Ph.D.; MUDr. Mgr. Marek Mráz, Ph.D.; prof. RNDr. Šárka Pospíšilová, Ph.D.; Magali Le Garff-Tavernier; MD Helene Merle-Béral, PhD; MD Tatjana Stankovic, PhD; MD Marinus H.J. Van Oers, PhD; Eric Eldering, PhD; MD Stephan Stilgenbauer; Prof. Dr. med. Thorsten Zenz; MD Arnon P. Kater, PhD
Číslo abstraktu: 2872
Kategorie: Maligní lymfomy a leukémie

Active Crosstalk with the Microenvironment Leading to Clonal Evolution in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors

Autoři: Lesley-Ann Sutton; Efterpi Kostareli; Evangelia Stalika; Athanasios Tsaftaris; Dr. Achilles Anagnostopoulos; Dr. Nikos Darzentas, PhD; Prof. MD Richard Rosenquist (Brandell), PhD; MD Kostas Stamatopoulos
Číslo abstraktu: 2878
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

The Target Genes and Prognostic Significance of Mir-150 in Chronic Lymphocytic Leukemia

Autoři: MUDr. Mgr. Marek Mráz, Ph.D.; Laura Z. Rassenti, PhD; Emanuela M. Ghia, PhD; MD Liguang Chen, PhD; Jessie-Farah Fecteau, PhD; prof. RNDr. Šárka Pospíšilová, Ph.D.; Hongying Li, PhD; Karen Messer, PhD; MD Thomas J. Kipps, PhD
Číslo abstraktu: 3859
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Microrna-34a As a Marker for Fludarabine Resistance and Impairment of p53-Pathway in Chronic Lymphocytic Leukemia

Autoři: MUDr. Mgr. Marek Mráz, Ph.D.; Kateřina Černá; Bc. Veronika Mayerová; Mgr. Kateřina Musilová; Mgr. Karla Plevová, Ph.D.; Mgr. Šárka Pavlová, PhD; MvDr. Boris Tichý, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; RNDr. Jitka Malčíková, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; Doc. MUDr. Martin Trbušek, PhD; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 3883
Kategorie: Maligní lymfomy a leukémie

Sequence Variations in miRNA Genes Are Common and May Affect Their Expression in Patients with Chronic Lymphocytic Leukemia

Autoři: PharmDr. Jana Kmínková; MUDr. Mgr. Marek Mráz, Ph.D.; Mgr. Veronika Navrkalová, Ph.D.; MvDr. Boris Tichý, Ph.D.; RNDr. Jitka Malčíková, Ph.D.; Mgr. Karla Plevová, Ph.D.; Vladimir Benes; Dr. Tobias Rausch; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Michael Doubek, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 3895
Kategorie: Maligní lymfomy a leukémie

Defects of ATM Gene Involving Mutation Lead to Complete Elimination of ATM Function in Chronic Lymphocytic Leukemia

Autoři: Mgr. Veronika Navrkalová, Ph.D.; RNDr. Ludmila Šebejová; Mgr. Jana Zemanová; PharmDr. Jana Kmínková; Mgr. Bc. Blanka Kubešová; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. RNDr. Jana Šmardová, CSc.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.; Doc. MUDr. Martin Trbušek, PhD
Číslo abstraktu: 3902
Kategorie: Maligní lymfomy a leukémie

T Cell Receptor Gene Repertoire Restriction in Chronic Lymphocytic Leukemia with Stereotyped IGHV4-34/IGKV2-30 Antigen Receptors

Autoři: MD Anna Vardi, MSc.; Andreas Agathaggelidis; Evangelia Stalika; Millaray Marincevic; Maria Karypidou; Dr. Achilles Anagnostopoulos; MD Chrysoula Belessi; Dr. Nikos Darzentas, PhD; Prof. MD Richard Rosenquist (Brandell), PhD; MD Kostas Stamatopoulos
Číslo abstraktu: 3908
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

Mutational Analysis of TP53 Gene in Chronic Lymphocytic Leukemia: Comparison of Different Methodological Approaches

Autoři: Mgr. Barbara Kantorová; RNDr. Jitka Malčíková, Ph.D.; PharmDr. Jana Kmínková; Mgr. Veronika Navrkalová, Ph.D.; Mgr. Barbora Dvořáková; MvDr. Boris Tichý, Ph.D.; prof. RNDr. Jana Šmardová, CSc.; Doc. MUDr. Martin Trbušek, PhD; Sim Truong; Mgr. Kateřina Staňo Kozubík; Mgr. Nikola Tom; Mgr. Karol Pál; RNDr. Ludmila Šebejová; Nancy Patten, PhD; Lin Wu, PhD; prof. MUDr. Michael Doubek, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 3911
Kategorie: Maligní lymfomy a leukémie

A Reappraisal of the Biological and Clinical Implications of Chromosomal Translocations in Chronic Lymphocytic Leukemia

Autoři: Panagiotis Baliakas; Michalis Iskas; Anne Gardiner; Zadie Davis; Mgr. Karla Plevová, Ph.D.; RNDr. Jitka Malčíková, Ph.D.; Dr. Achilles Anagnostopoulos; Sharron Glide; Sarah Mould; MvDr. Gabriela Vaňková; prof. RNDr. Šárka Pospíšilová, Ph.D.; Anastasia Athanasiadou; MD Kostas Stamatopoulos; Prof. David Graham Oscier
Číslo abstraktu: 3915
Kategorie: Maligní lymfomy a leukémie

642. CLL - Therapy, excluding Transplantation

Extended Follow up of the CLL8 Protocol, a Randomized Phase-III Trial of the German CLL Study Group (GCLLSG) Comparing Fludarabine and Cyclophosphamide (FC) to FC Plus Rituximab (FCR) for Previously Untreated Patients with Chronic Lymphocytic Leukemi

Autoři: M.D. Kirsten Fischer; Jasmin Bahlo; MD Anna-Maria Fink; Dipl.Math. Raymonde Busch, Ph.D.; MD Sebastian Böttcher; prof. MUDr. Jiří Mayer, CSc.; Prof. Dr.med. Peter Dreger; Christian Maurer; Anja Engelke; MD Michael Kneba, PhD; Prof. Dr. med. Hartmut Döhner (Doehner); MD Barbara Eichhorst; MD Clement Martin Wendtner; MD Stephan Stilgenbauer; Prof. MD Michael Hallek
Číslo abstraktu: 0435
Kategorie: Maligní lymfomy a leukémie

Fludarabine, Cyclophosphamide and Rituximab (FCR) Related Prolonged Cytopenia Is Frequent and Adverse Factor Affecting Survival of Patients with Chronic Lymphocytic Leukemia (CLL)

Autoři: MUDr. Petra Obrtlíková, Ph.D.; doc. MUDr. Anna Jonášová, Ph.D.; MUDr. Magda Šišková, CSc.; MUDr. Eduard Cmunt, CSc.; MUDr. Adéla Berková; MUDr. Josef Karban, CSc.; Bc. Kateřina Šváčková; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 1790
Kategorie: Maligní lymfomy a leukémie

651. Myeloma - Biology and Pathophysiology, excluding Therapy

Extramedullary Relapse of Multiple Myeloma - Plasma Cells Characteristics

Autoři: prof. MUDr. Luděk Pour, Ph.D.; doc. RNDr. Sabina Ševčíková, Ph.D.; Mgr. Lucie Říhová, PhD.; Mgr. Lenka Bešše (Kubiczková); RNDr. Henrieta Grešliková; Renata Kupská; MUDr. Fedor Kryukov; MUDr. Elena Dementyeva; Mgr. Aneta Mikulášová; MUDr. Lenka Zahradová, Ph.D.; prof. MUDr. Zdeněk Adam, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 2953
Kategorie: Mnohočetný myelom

84. Evaluation of Immune Suppression in Multiple Myeloma Patients Treated with Lenalidomide Plus Prednisone and Lenalidomide Alone

Autoři: Mgr. Karthick Raja Muthu Raja; Mgr. Lucie Říhová, PhD.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 3969
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie

653. Myeloma - Therapy, excluding Transplantation

Treatment with Bendamustine-Bortezomib-Dexamethasone (BBD) in Relapsed/Refractory Multiple Myeloma Shows Significant Activity and Is Well Tolerated

Autoři: Prof. MD Heinz Ludwig; MD Hedwig Kasparu; MD Richard Greil, Ph.D.; MD Clemens Leitgeb; MD Ercan Müldür; Elisabeth Rauch; Dr. Niklas Zojer; MD Eva-Maria Autzinger; Univ.-Prof. Dr.med.univ. Werner Linkesch; Thomas Kuhr; prof. MUDr. Luděk Pour, Ph.D.; prof. MUDr. Zdeněk Adam, CSc.
Číslo abstraktu: 0943
Kategorie: Mnohočetný myelom

Bortezomib (Velcade) in the Treatment of Relapsed or Refractory Multiple Myeloma: Analysis of Safety and Efficacy of Bortezomib From Registry of Monoclonal Gammopathy of Czech Myeloma Group

Autoři: MUDr. Viera Sandecká, Ph.D.; Prof.MUDr. Ivan Špička, PhD; Doc. MUDr. Vladimír Maisnar, Ph.D.; MUDr. Tomáš Pika; MUDr. Evžen Gregora; MUDr. David Starostka; MUDr. Lenka Walterová; MUDr. Jaromír Gumulec; MUDr. Dagmar Adamová; MUDr. Marek Wróbel; MD Ivan Vonke; MUDr. Lenka Zahradová, Ph.D.; MUDr. Jan Straub; MUDr. Jakub Radocha; MUDr. Jiří Minařík, Ph.D. ; MUDr. Petr Pavlíček; MUDr. Petr Kessler; prof. MUDr. Luděk Pour, Ph.D.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 1872
Kategorie: Mnohočetný myelom

Significant Activity of Lenalidomide-Dexamethasone in Multiple Myeloma (MM) Patients with Light Chain Induced Acute Renal Failure (LC-ARF)

Autoři: Prof. MD Heinz Ludwig; Elisabeth Rauch; Thomas Kuhr; Dr. Adalbert Weissmann (Weißmann); Daniel Heintel; Dr. Niklas Zojer; MD Hedwig Kasparu; MD Richard Greil, Ph.D.; prof. MUDr. Zdeněk Adam, CSc.
Číslo abstraktu: 4031
Kategorie: Mnohočetný myelom

721. Clinical Allogeneic Transplantation - Conditioning Regimens, Engraftment and Acute Transplant Toxicities

JMML Revisited: Role Und Outcome of Hematopoietic Stem Cell Transplantation in Subtypes of Juvenile Myelomonocytic Leukemia (JMML)

Autoři: Prof. MD Charlotte M. Niemeyer, PhD; MD Brigitte Strahm; Prof. MD Michael Dworzak; MD Barbara De Moerloose; Prof. MD Henrik Hasle; prof. MUDr. Jan Starý, DrSc.; MD Markus Schmugge (Schmugge-Liner); Marek Ussowicz; MD Marry M. van den Heuvel-Eibrink, PhD; MD Marco Zecca; Jonas Abrahamsson; MD Marc Bierings; Victoria Bordon; Susanne Matthes-Martin; prof. MUDr. Petr Sedláček, CSc.; Thomas Gorr; Alexandra Fischer, R.N.; Peter Noellke; prof. MD Christian M. Flotho; Prof. MD Franco Locatelli, PhD
Číslo abstraktu: 0955
Kategorie: Maligní lymfomy a leukémie

723. Clinical Allogeneic and Autologous Transplantation - Late Complications and Approaches to Disease Recurrence

Factors Affecting Quality of Life During and After Stem Cell Transplantation in Long Term Survivors – Comparison of Autologous and Allogeneic Stem Cell Transplantation

Autoři: MUDr. Kateřina Benešová, CSc.; Mgr. Marie Trnková; MUDr. Miriam Lánská; MUDr. Veronika Válková, CSc.; MUDr. Kateřina Steinerová; MUDr. Zdeněk Kořístek; MD Jan Novák, Ph.D.; MUDr. Luděk Raida, Ph.D.; MUDr. Petra Keslová; MUDr. Blanka Vacková; Ing. Klára Kruntorádová; MUDr. Tomáš Doležal; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 0590
Kategorie: Maligní lymfomy a leukémie

731. Clinical Allogeneic and Autologous Transplantation - Results: Autologous or Allogeneic Transplantation

Early Allogeneic Hematopoietic Cell Transplantation in Patients with High Risk AML - Final Results From the Randomized AML 2003 Trial

Autoři: MD Johannes Schetelig, MSC; MD Marcus Schaich; MD Christoph Röllig; Dr. Kerstin Schäfer-Eckart; MD Mathias Hänel; Walter E. Aulitzky; MD Hermann Einsele; Prof. MD Hubert Serve; MD Norbert Schmitz; MD Wolfgang E. Berdel; MD Matthias Stelljes; Wolf Rösler; prof. MUDr. Jiří Mayer, CSc.; Albrecht Reichle; Claudia D. Baldus; Prof.MD Anthony D. Ho, PhD, FRCP; Michael Kramer; MD Uwe Platzbecker; M.D. Christian Thiede; Prof. Dr. Martin Bornhaeuser (Bornhäuser); MD Gerhard Ehninger
Číslo abstraktu: 0229
Kategorie: Maligní lymfomy a leukémie

Outcome and Prognostic Factors in Patients with Mantle Cell Lymphoma Relapsing After Autologous Stem Cell Transplantation: A Retrospective Study of the EBMT

Autoři: MD Sascha Dietrich; Herve Finel; Ariane Boumendil, Ph.D.; MD Irit Avivi; MD Liisa Volin, Ph.D.; MD Jan Cornelissen, PhD; MD Jan Andrzej Walewski, Ph.D.; Dr. Christoph Schmid; MD Theo M. de Witte; MD Harry C. Schouten, PhD; MD Martin Kaufmann; MD Catherine Sebban; Prof. MUDr. Marek Trněný, CSc.; MD Guido Kobbe; Philippe Guardiola; MD Johannes Schetelig, MSC; MD Michael Pfreundschuh; MD Jose L. Diez-Martin, PhD; MD Dominique Bordessoule , PhD; Stephen Robinson, MBBS, MRCP, FRCPath, PhD; Prof. Dr.med. Peter Dreger
Číslo abstraktu: 0474
Kategorie: Maligní lymfomy a leukémie

Equivalent Outcome Between Older Siblings and Unrelated Donors After Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for Patients Older Than 50 Years with Acute Myeloid Leukemia in First Complete Remission: A Report From the ALWP

Autoři: Regis Peffault de Latour; MD Myriam Labopin, MS; MD Jan Cornelissen, PhD; MD Lars Vindelov; Prof. Dr. Didier Blaise; MD Noel-Jean Milpied, Ph.D.; MD Anne Huyn; Prof. MD Charles F. Craddock, BM, MRCP, MRCPath; Prof. MD Nigel H. Russell; MUDr. Vladimír Koza (1954 - 2012); MD Bruno Lioure; Richard Schouten, BSc; MD Dolores Caballero; MD Jean-Yves Cahn, PhD; MD Nathalie Fegueux; MD Mohamad Mohty, PhD
Číslo abstraktu: 0961
Kategorie: Maligní lymfomy a leukémie

Long-Term Outcomes of Autologous Transplantation in Multiple Myeloma: Prognostic Significance of Complete Response

Autoři: Prof. MUDr. Marta Krejčí, Ph.D.; prof. MUDr. Roman Hájek, CSc.; prof. MUDr. Zdeněk Adam, CSc.; prof. MUDr. Luděk Pour, Ph.D.; MUDr. Lenka Zahradová, Ph.D.; Mgr. Jana Pelcová; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 3126
Kategorie: Mnohočetný myelom

901. Health Services and Outcomes Research

Patient-Reported Fatigue, Functional Aspects and Quality of Life in Elderly Patients with High-Risk Myelodysplastic Syndromes. Evidence From a Large Prospective International Study

Autoři: Fabio Efficacce, PhD; MD Gianluca Gaidano, PhD; MD Maria Teresa Voso; MD Giovanni Caocci; Massimo Breccia; MD Reinhard Stauder; MD Dominik Selleslag; Dott.ssa Maria Grazia Sanpaolo; MD Uwe Platzbecker; Marianna Criscuolo; MD Anna Angela Di Tucci; MD Monia (Monica) Lunghi; doc. MUDr. Anna Jonášová, Ph.D.; Dr. Francesco Buccisano; Alessandra Ricco; MD Zhang Huiyong; MD David Bowen, Ph.D.; ChD Giuseppe A. Palumbo, PhD; MD Pasquale Niscola, PhD; Dr. Francesco Cottone; Dr. Marco Vignetti; MD Franco Mandelli
Číslo abstraktu: 3163
Kategorie: Myelodysplastický syndrom