2012 48th ASCO Annual Meeting - účast ČR

Breast Cancer - HER2/ER

Everolimus for postmenopausal women with advanced breast cancer: Updated results of the BOLERO-2 phase III trial.

Autoři: Martine J. Piccart-Gebhart; Prof. Shinzaburo Noguchi; Prof. Kathleen I. Pritchard, MD, FRCP; Howard A. Burris; Hope S. Rugo; Prof. Dr. Michael Gnant; Gabriel N. Hortobagyi, MD, FACP; prof. MUDr. Bohuslav Melichar, Ph.D.; MUDr. Katarína Petráková, Ph.D.; MD Francis P. Arena, FACP; Cindy Xu; Ayelet Cahana; Tanya Taran; Tarek Sahmoud; David Edward Lebwohl; Mario Campone; MD José Baselga, PhD
Číslo abstraktu: 559
Kategorie: Zhoubné nádory prsu

Reasons for changing hormonal therapy of advanced breast cancer.

Autoři: MUDr. Katarína Petráková, Ph.D.; prof. MUDr. Luboš Petruželka, CSc.; MUDr. Vít Kandrnál
Číslo abstraktu: e11047
Kategorie: Zhoubné nádory prsu

Lapatinib efficacy according to metastatic sites in trastuzumab pretreated patients with HER2-positive metastatic breast cancer: An analysis form IntERB registry in the Czech Republic.

Autoři: MUDr. Peter Grell, Ph.D.; MUDr. Vít Kandrnál; Mgr. Zbyněk Bortlíček; prof. MUDr. Rostislav Vyzula, CSc.
Číslo abstraktu: e11072
Kategorie: Zhoubné nádory prsu

Breast Cancer - Triple-Negative/Cytotoxics/Local Therapy

BCL2 protein in prediction of relapse in triple-negative breast cancer (TNBC) treated with adjuvant anthracycline-based chemotherapy.

Autoři: MUDr. Kateřina Bouchalová (Špačková), Ph.D.; prof. MUDr. Marek Svoboda, Ph.D.; MUDr. Gvantsa Kharaishvili, Ph.D.; Mgr. Lenka Radová, Ph.D.; doc. Mgr. Jan Bouchal, Ph.D.; RNDr. Radek Trojanec, Ph.D.; doc. MUDr. Marián Hajdúch, Ph.D.; MUDr. Karel Cwiertka, Ph.D.; prof. MUDr. Zdeněk Kolář, CSc.
Číslo abstraktu: 1087

Developmental Therapeutics - Experimental Therapeutics

Phase I/II study of the investigational aurora A kinase (AAK) inhibitor MLN8237 (alisertib) in patients (pts) with non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), breast cancer (BrC), head/neck cancer (H&N), and gastroesophageal (G

Autoři: Peter Lee; Ricardo H. Alvarez; prof. MUDr. Bohuslav Melichar, Ph.D.; Pr. Antoine Adenis; Dr. Jaafar Bennouna; Claudia Schusterbauer; Bin Zhang, DSc; Ely Benaim, MD; Peter J. Rosen
Číslo abstraktu: 3010
Kategorie: Gastrointestinální nádory; Nádory hlavy a krku; Zhoubné nádory plic a průdušek; Zhoubné nádory prsu

Gastrointestinal (Colorectal) Cancer

Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: A phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen.

Autoři: Carmen Joseph Allegra; doc. MUDr. Radek Lakomý, Ph.D.; Josep Tabernero, MD; Doc. MUDr. Jana Prausová, Ph.D., MBA; Prof. M.D. Paul Ruff; Dr. Guy van Hazel; Vladimir Mikhailovich Moiseyenko; Prof. M.D. David R. Ferry, Ph.D.; Prof. Joseph McKendrick; Eric Van Cutsem
Číslo abstraktu: 3505
Kategorie: Kolorektální karcinom

Phase I study of EMD 525797 (DI17E6), an antibody targeting ανβ integrins, in combination with cetuximab and irinotecan, as a second-line treatment for patients with k-ras wild-type metastatic colorectal cancer.

Autoři: Elena Élez; doc. MUDr. Ilona Kocáková, Ph.D.; Thomas Hoehler; M.D. Uwe Marc Martens; Prof. Dr. med. Carsten Bokemeyer; Eric Van Cutsem; Robert J. Fram; Laurence Bernard; Josep Tabernero, MD
Číslo abstraktu: 3539
Kategorie: Gastrointestinální nádory

Meta-analysis of anti-VEGF class adverse events from three double-blind (db), placebo (pbo)-controlled phase III trials with IV aflibercept (Afl).

Autoři: Josep Tabernero, MD; Carmen Joseph Allegra; Philippe R. Rougier; Giorgio Scagliotti; Philip Agop Philip; doc. MUDr. Radek Lakomý, Ph.D.; Rodryg Ramlau; Sylvie Assadourian; Soazig Chevalier; Eric Van Cutsem
Číslo abstraktu: 3579
Kategorie: Gastrointestinální nádory

Gastrointestinal (Noncolorectal) Cancer

Occult tumor cells in peritoneal lavage in pancreatic carcinoma patients.

Autoři: MUDr. Josef Srovnal, Ph.D.; Mgr. Andrea Benedíková; doc. MUDr. Roman Havlík, Ph.D.; MUDr. JUDr. Dušan Klos, Ph.D., LL.M.; MUDr. Martin Loveček, Ph.D.; Bc. Dana Cahová; prof. MUDr. Bohuslav Melichar, Ph.D.; doc. MUDr. Marián Hajdúch, Ph.D.
Číslo abstraktu: e14556
Kategorie: Gastrointestinální nádory

Perioperative management of patients with distal esophagus and gastroesophageal junction tumors: Three years of results.

Autoři: Doc. MUDr. Milada Zemanová, Ph.D.; MUDr. Zdeňka Pechačová, Ph.D.; MUDr. Tomáš Haruštiak, Ph.D.; MUDr. Pavel Fencl, CSc.; MUDr. Pavel Vítek, PhD.; prof. MUDr. Luboš Petruželka, CSc.
Číslo abstraktu: e14631
Kategorie: Gastrointestinální nádory

Genitourinary Cancer

Axitinib for first-line metastatic renal cell carcinoma (mRCC): Overall efficacy and pharmacokinetic (PK) analyses from a randomized phase II study.

Autoři: MD Brian I. Rini; PD Dr. Viktor Grünwald (Gruenwald); MD Mayer N. Fishman, Ph.D.; prof. MUDr. Bohuslav Melichar, Ph.D.; MD Takeshi Ueda, Ph.D.; Petr A. Karlov; Angel H. Bair; Ying Chen; Sinil Kim; Dr. Eric Jonasch
Číslo abstraktu: 4503
Kategorie: Genitourinární nádory

Radium-223 chloride (Ra-223) impact on skeletal-related events (SREs) and ECOG performance status (PS) in patients with castration-resistant prostate cancer (CRPC) with bone metastases: Interim results of a phase III trial (ALSYMPCA).

Autoři: MD A. Oliver Sartor; Daniel Heinrich; Joe M. O'Sullivan; Sophie D. Fossa; MUDr. Aleš Chodacki; Pawel J. Wiechno ; John P. Logue; Mihalj Seke; Anders Widmark; Dag Clement Johannessen; Sten Nilsson ; Peter Hoskin ; David Bottomley; M.D. Robert Edward Coleman; Nicholas J. Vogelzang; C. Gillies O'Bryan-Tear; Jose E. Garcia-Vargas; Minghua Shan; Chris Parker
Číslo abstraktu: 4551
Kategorie: Genitourinární nádory

Updated analysis of the phase III, double-blind, randomized, multinational study of radium-223 chloride in castration-resistant prostate cancer (CRPC) patients with bone metastases (ALSYMPCA).

Autoři: Chris Parker ; Sten Nilsson ; Daniel Heinrich; Joe M. O'Sullivan; Sophie D. Fossa; MUDr. Aleš Chodacki; Pawel J. Wiechno ; John P. Logue; Mihalj Seke; Anders Widmark; Dag Clement Johannessen; Peter Hoskin ; David Bottomley; M.D. Robert Edward Coleman; Nicholas J. Vogelzang; C. Gillies O'Bryan-Tear; Jose E. Garcia-Vargas; Minghua Shan; MD A. Oliver Sartor
Číslo abstraktu: LBA4512
Kategorie: Genitourinární nádory

First-line use of cabazitaxel in chemotherapy-naive patients with metastatic castration-resistant prostate cancer (mCRPC): A three-arm study in comparison with docetaxel.

Autoři: Dr. Stephane Oudard; Lisa Sengelov; Paul N. Mainwaring; Antoine Thiery- Vuillemin; Christine Theodore; Evgeny Kulikov; Jeffrey Yachnin; MUDr. Ivo Kocák, Ph.D.; Vesa V Kataja; Marjaana Luukkaa; Alexander Nosov; Marie Hjelm-Eriksson; Jeffrey Bubis; Liji Shen; Marie-Laure Risse; MD A. Oliver Sartor
Číslo abstraktu: TPS4696
Kategorie: Genitourinární nádory

Gynecologic Cancer

Olaparib plus paclitaxel plus carboplatin (P/C) followed by olaparib maintenance treatment in patients (pts) with platinum-sensitive recurrent serous ovarian cancer (PSR SOC): A randomized, open-label phase II study.

Autoři: Amit M. Oza; prof. MUDr. David Cibula, CSc.; Ana Oaknin; Christopher John Poole; Prof. M.D. Ron H.J. Mathijssen, Ph.D.; Gabe S. Sonke; Prof. Dr. Nicoletta Colombo, PhD; Prof. MUDr. Jiří Špaček, Ph.D., IFEPAG; Peter Vuylsteke; Dr. Hal W. Hirte; Prof. Dr. Swen Mahner; Marie Plante; Barbara Schmalfeldt; Helen J. Mackay; Jacqui Rowbottom; Ilian Tchakov; Michael Friedlander
Číslo abstraktu: 5001
Kategorie: Zhoubné gynekologické nádory

Leukemia, Myelodysplasia, and Transplantation

Post hoc analysis of relationship between baseline white blood cell count and survival outcome in a randomized phase III trial of decitabine in older patients with newly diagnosed acute myeloid leukemia.

Autoři: MD Christopher Arthur; prof. MUDr. Jaroslav Čermák, CSc.; MD Jacques Delaunay; prof. MUDr. Jiří Mayer, CSc.; MD Grzegorz Mazur, PhD; MD Xavier G. Thomas; MD Agnieszka Wierzbowska, PhD; MD Mark M. Jones; Peter G. Tarassoff; M.D. Hagop M. Kantarjian
Číslo abstraktu: 6559
Kategorie: Maligní lymfomy a leukémie

Ofatumumab retreatment and maintenance in patients with fludarabine-refractory CLL.

Autoři: MD Anders Österborg, PhD; Prof. M.D. Martin John Swinnerton Dyer; prof. MUDr. Jiří Mayer, CSc.; MD Georg Hess; Peter Hillmen, M.B. ChB, Ph.D.; MD Johannes Schetelig, MSC; M.D. Anna Schuh, Ph.D.; MUDr. Lukáš Smolej, Ph.D.; Christian Beck; Brigitte Dreyfus; MD Andrzej Hellmann, Ph.D.; Piotr Kozlowski; MD Michael Pfreundschuh; Ritta Rizzi; MUDr. Martin Špaček; MD Geoffrey (W.) Chan; MD Ira (V.) Gupta; Jennifer Phillips; MD Steen Lisby, DMSc; MD William G. Wierda, PhD
Číslo abstraktu: 6584
Kategorie: Maligní lymfomy a leukémie

Post hoc analysis of association between treatment response and various indicators of efficacy and safety in a randomized phase III trial of decitabine in older patients with acute myeloid leukemia.

Autoři: MD Mark D. Minden, PhD, FRCPC; MD Christopher Arthur; prof. MUDr. Jiří Mayer, CSc.; MD Mark M. Jones; Peter G. Tarassoff; M.D. Hagop M. Kantarjian
Číslo abstraktu: 6627
Kategorie: Maligní lymfomy a leukémie

Lung Cancer - Non-small Cell Metastatic

Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous NSCLC.

Autoři: Prof. Suresh S. Ramalingam, MD; Mikhail Shtivelband; Ross A. Soo; Prof. MD Carlos Henrique Barrios; Anatoly Makhson; J.G.M. Segalla; Kenneth B. Pittman; MUDr. Petr Kolman; Jose Rodrigues Pereira; Gordan Srkalovic; Chandra Prakash Belani; Rita Axelrod; Taofeek Kunle Owonikoko; Jiang Qian; Mark D. McKee; Justin L. Ricker; Dawn M. Carlson; Vera A. Gorbunova
Číslo abstraktu: 7512
Kategorie: Zhoubné nádory plic a průdušek

Prospective randomized phase II trial of oral vinorelbine (NVBo) and cisplatin (P) or pemetrexed (Pem) and P in first-line metastatic or locally advanced non-small cell lung cancer (M or LA NSCLC) patients (pts) with nonsquamous (non SCC) histologic

Autoři: Dr. Jaafar Bennouna; prof. MUDr. Petr Zatloukal (1955-2012), CSc.; Maciej Jerzy Krzakowski; Jens Kollmeier; Alain Riviere; Eric Dansin; Monika Serke; Adolfo G. Favaretto; MUDr. Libor Havel; Stephanie Malasse; Fabienne Biville-Hedouin; Eng Huat Tan
Číslo abstraktu: 7575
Kategorie: Zhoubné nádory plic a průdušek

Characteristics of advanced NSCLC patients with at least 6 months erlotinib treatment duration in Czech Republic.

Autoři: MUDr. Helena Čoupková; prof. MUDr. Jana Skřičková, CSc.; PhDr. Karel Hejduk; Mgr. Zbyněk Bortlíček; MUDr. Bohdan Kadlec; Doc. MUDr. František Salajka, CSc.; prof. MUDr. Miloš Pešek, CSc.; prof. MUDr. Vítězslav Kolek, DrSc.; MUDr. Leona Koubková; MUDr. Dimka Sixtová; prof. MUDr. Petr Zatloukal (1955-2012), CSc.; MUDr. Jaromír Roubec, Ph.D.; Doc. MUDr. Milada Zemanová, Ph.D.; prof. MUDr. Rostislav Vyzula, CSc.; MUDr. Stanislav Špelda
Číslo abstraktu: e18062
Kategorie: Zhoubné nádory plic a průdušek

Lymphoma and Plasma Cell Disorders

Phase II, randomized, double blind, placebo-controlled study comparing siltuximab plus bortezomib versus bortezomib alone in pts with relapsed/refractory multiple myeloma.

Autoři: M.D. Robert Z. Orlowski, Ph.D., M.P.H.; M.D. Liana Gercheva; Catherine D. Williams, MBBS, MRCP, FRCPath; MD Heather J. Sutherland, PhD, FRACP; MD Tadeusz Robak, PhD.; MD Tamas Masszi, PhD; MD Vesselina Goranova-Marinova, PhD; Meletios Athanasios Dimopoulos, MD; Prof. MD James D. Cavenagh; Prof.MUDr. Ivan Špička, PhD; Angelo Maiolino; M.D. Alexander Suvorov; Prof. Dr. Joan Bladé, PhD; MD Olga S Samoilova; MD Helgi van de Velde, PhD; Rajesh Bandekar; Britte Kranenburg; Hong Xie; Jean-Francois Rossi
Číslo abstraktu: 8018
Kategorie: Mnohočetný myelom

Regional differences in the treatment approaches for relapsed multiple myeloma: An IMF study.

Autoři: Brian G.M. Durie; Prof. MD Philippe Moreau; MD Pieter Sonneveld, PhD.; Prof. M.D. Gareth J. Morgan, FRCP, FRCPath, Ph.D.; Juan José Lahuerta; prof. MD Meral Beksac; Evangelos Terpos; prof. MUDr. Roman Hájek, CSc.; Vânia Tietsche de Moraes Hungria; Angelo Maiolino; Wee Joo Chng; Jae Hoon Lee; Hou Jian; MD Paul Gerard Guy Richardson; Wenming Chen; Stefan Knop; Antje Hoerring; MD Xavier Leleu, PhD; Prof. M.D. Jesús San Miguel, Ph.D.; M.D. Shaji Kumar
Číslo abstraktu: 8095
Kategorie: Mnohočetný myelom

Evaluation of MLN4924, an investigational NEDD8-activating enzyme (NAE) inhibitor, as a novel targeted agent with single-agent antitumor activity in mantle cell lymphoma (MCL) and Hodgkin lymphoma preclinical models.

Autoři: Richa Dawar; MD Matthew John Barth; BSc Cory Mavis, MSc; Jospeh J. Skitzki; MD Myron Stefan Czuczman; prof. MUDr. Pavel Klener, DrSc.; MD Francisco J. Hernandez-Ilizaliturri
Číslo abstraktu: e18539
Kategorie: Maligní lymfomy a leukémie

Melanoma/Skin Cancers

Analysis of BRAF mutation status in high-risk malignant melanoma patients having received HD IFNa therapy in adjuvant setting.

Autoři: MUDr. Zuzana Hlavatá; MUDr. Tomáš Šálek, Ph.D.; MUDr. Iveta Andrezálová Vochyanová; MUDr. Jozef Dolinský; Veronika Švábová; MUDr. Štefan Pörsök; Mgr. Jitka Berkovcová, Ph.D.; Doc.RNDr. Iveta Waczulíková, Ph.D.
Číslo abstraktu: e19020
Kategorie: Maligní melanom a nádory kůže

Tumor Biology

Determining the metastatic potential of circulating tumor cells.

Autoři: Rhiana Menen; Emmett Pinney; Mgr. Katarína Kološtová, Ph.D.; Prof. MUDr. Vladimír Bobek, Ph.D.; Atsushi Suetsugu; Nan Zhang; Robert M. Hoffman
Číslo abstraktu: e21051
Kategorie: Nádorová biologie/imunologie/genetika a buněčná terapie