2010 52nd ASH Annual Meeting – účast ČR

Acute Lymphoblastic Leukemia

Silencing of TEL/AML1 In Definitive Leukemic Cells Does Not Impair Cell Survival

Autoři: MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Mgr. Jozef Madžo, Ph.D.; MD Gunnar Cario; Prof.MUDr. Jan Trka, Ph.D.
Číslo abstraktu: 3229
Kategorie: Maligní lymfomy a leukémie

Acute Myeloid Leukemia

Excellent Outcome In Infants below One Year of Age with AML – Results of Studies AML-BFM -98 and -2004

Autoři: MD Ursula Creutzig, PhD; Martin Zimmermann, Ph.D.; Prof. MD Michael Dworzak; MD Jean-Pierre Bourquin, PhD; MD Christine von Neuhoff; MD Annette Sander; prof. MUDr. Jan Starý, DrSc.; MD Dirk Reinhardt, PhD
Číslo abstraktu: 17
Kategorie: Maligní lymfomy a leukémie

Study AML-BFM 2004: Improved Survival In Childhood Acute Myeloid Leukemia without Increased Toxicity

Autoři: MD Ursula Creutzig, PhD; Martin Zimmermann, Ph.D.; Prof. MD Michael Dworzak; MD Jean-Pierre Bourquin, PhD; MD Christine von Neuhoff; MD Annette Sander; prof. MUDr. Jan Starý, DrSc.; MD Dirk Reinhardt, PhD
Číslo abstraktu: 181
Kategorie: Maligní lymfomy a leukémie

Central Nervous System (CNS) Involvement In Pediatric Relapsed Acute Myeloid Leukemia: Results and Lessons From Study Relapsed AML 2001/01

Autoři: MD Gertjan (J.L.) Kaspers, PhD; Martin Zimmermann, Ph.D.; MD Dirk Reinhardt, PhD; Brenda Gibson; Rienk Tamminga; Prof. M.D. Olga Aleinikova; Hortensia Armendariz; Prof. MD Michael Dworzak; Ha S.; Prof. Liisa Hovi; Alexei Maschan; MD Andre Baruchel, PhD; M.D. Yves Bertrand; Bassem Razzouk; Carmelo Rizzari; MUDr. Petr Smíšek
Číslo abstraktu: 184
Kategorie: Maligní lymfomy a leukémie; zhoubné nádory mozku a CNS

Clinical Care

Incidence and Risk Factors for Secondary Autoimmune Diseases (AD) After Hematopoietic Stem Cell Transplantation (HSCT) for a Severe Autoimmune Disease-A Retrospective EBMT WP AD Study

Autoři: MD Thomas Daikeler; MD Myriam Labopin, MS; Massimo di Gioia; Mario Abinun; Dr. Tobias Alexander; Irene Miniati; Francesca Gualandi; Athanasios Fassas; Martin Thierry; Carl-Philipp Schwarze; Nico Wulffraat; Maya Buch; Antonia Sampol; Enric Carreras; Benedict Dubois
Číslo abstraktu: 2322
Kategorie: Ostatní

Incidence and Risk Factors for Secondary Autoimmune Diseases (AD) After Cord Blood Transplantation (CBT). Retrospective Analysis on Behalf of Eurocord and the EBMT Autoimmune Diseases Working Party

Autoři: MD Thomas Daikeler; MD Myriam Labopin, MS; MD Gerard Socié, Ph.D.; MD Maura Faraci; Fawzi Abdel-Rahman; Prof. MD M. Akif Yesilipek; MD William Arcese; MD Anne OMeara; MD Anne Sirvent; MD Jan Voswinkel; MD Amparo Verdeguer; MD Virginie Gandemer; MD Helene Schoemans; MD Andrew J. Cant; MD Chiara Messina; prof. MUDr. Petr Sedláček, CSc.; prof. MUDr. Ajay J. Vora, MD, FRCP, FRCPath; MD Valerie Mialou; MD Jose Louis Díez; MD Federica Sorà; MD Charlotte Jubert; MD Andrée-Laure Herr; MD Annalisa Ruggeri; MD Alessandro Crotta; MD Eliane Gluckman; MD Dominique Farge; MD Vanderson Rocha, PhD.
Číslo abstraktu: 3460
Kategorie: Ostatní

Gene-Expression Profile of Steroid-Refractory Acute Graft-Versus-Host Disease

Autoři: Ing. Jan Verner, Ph.D.; RNDr. Jitka Kabáthová; Doc. RNDr. Zbyněk Zdráhal, Dr.; Alexandra Tomancova; MUDr. Jana Volejníková; MUDr. Yvona Brychtová, Ph.D.; prof. RNDr. Šárka Pospíšilová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 4549
Kategorie: Ostatní

Randomized Controlled Trial of Two Different Dosing Regimens of Palifermin to Prevent Mucositis In Multiple Myeloma Patients Receiving One-Day Administration of High-Dose Melphalan

Autoři: Nicole M.A. Blijlevens; Maarten E de Chateau; MD Gergely Krivan, PhD; Dr. Werner Rabitsch, M.D.; Arpad Szomor; MUDr. Robert Pytlík, Ph.D.; Agneta Lissmats; Prof. Hans Erik Johnsen; Tapani Ruutu; MD Hermann Einsele; MD Dietger W Niederwieser
Číslo abstraktu: 904
Kategorie: Mnohočetný myelom

Clinical Results

Sufficient and Timely Autologous Stem Cell Harvest After Chemoimmunotherapy with Alemtuzumab In Combination with Bi-Weekly CHOP as First Line Treatment In Systemic Peripheral T-Cell Lymphomas (PTCL): a Feasibility Analysis From the First Randomized T

Autoři: Francesco dAmore; M.D. Maria Gomes da Silva, Ph.D.; prof. Sirpa Leppä; Antonio Pezzutto; Thomas Relander; Grete Fossum Lauritzsen; Eckhart Weidmann; Michel Van Gelder; MD Jeanette K Doorduijn, PhD; Johanna C. Kluin-Nelemans; Marinus van Marwijk Kooy; Rob Fijnheer; Okke de Weerdt; Peter de Nully Brown
Číslo abstraktu: 2395
Kategorie: Maligní lymfomy a leukémie

DMSO Reduction Strategies Reduce DMSO Induced Post Autologous Transplant Morbidity In Patients with Lymphoma and Myeloma –Results from an EBMT Non Interventional Prospective Study

Autoři: MD Curly TCM Morris; Marijke Scholten; Liesbeth C. de Wreede, Ph.D.; Anja van Biezen; Ebbe Dickmeiss; Prof. MUDr. Marek Trněný, CSc.; Prof. Jane F. Apperley, MBChB, MD, FRCP, FRCPath; Patrizia Chiusolo; Gustaaf Van Imhoff; MD Stig Lenhoff, PhD; Lutz Uharek; Prof.MD Giovanni Martinelli; Marcus Hentrich; Anna Sureda, MD; Theo M. de Vite; Tapani Ruutu
Číslo abstraktu: 2397
Kategorie: Maligní lymfomy a leukémie

Rituximab Purging and Maintenance Improves Progression Free Survival but Not Overall Survival In Patients with Relapsed or Resistant Follicular Lymphoma Prior Receiving An Autologous Transplant

Autoři: Ruth Pettengel, MBchB, FRACP, PhD; MD Norbert Schmitz; MD Christian Gisselbrecht; Graeme Smith; William N Patton; Bernd Metzner; MD Dolores Caballero; MD Herve Tilly; MD Jan Andrzej Walewski, Ph.D.; Isabelle Bence-Bruckler; To Bik; MD Christian H. Geisler, PhD; Rik Schots; MD Eva Kimby, PhD; Christian J. Tavern
Číslo abstraktu: 3567
Kategorie: Maligní lymfomy a leukémie

Disordered Gene Expression in Hematologic Malignancy

High IGSF4 expression In Pediatric Acute Monoblastic Leukemia with t(9;11)

Autoři: MD Eva A Coenen; Jenny Kuipers; Brian V Balgobind; prof. MUDr. Jan Starý, DrSc.; MD Andre Baruchel, PhD; MD Valerie de Haas, Ph.D.; MD Eveline S.J.M. de Bont, PhD; MD Dirk Reinhardt, PhD; MD Gertjan (J.L.) Kaspers, PhD; Jacqueline Cloos, Ph.D.; Astrid A Danen-van Oorschot, PhD; Monique L. den Boer, PhD, MSc; Rolf Marschalek; Claus Meyer; Prof. MD Rob Pieters, PhD
Číslo abstraktu: 3614
Kategorie: Maligní lymfomy a leukémie

Epor Over-Expression In TEL-AML1 Positive ALL: Critical Roles for DNA Methylation, GATA-2 or MicroRNAs?

Autoři: Marie Breen; Vivien Hodges; MUDr. Markéta Kubričanová-Žaliová, Ph.D.; Prof.MUDr. Jan Trka, Ph.D.; Terence R.J. Lappin; Prof. Dr. Ken I. Mills, PhD
Číslo abstraktu: 3619
Kategorie: Maligní lymfomy a leukémie

Gene Expression Changes In Patients with 5q- Syndrome Treated with Lenalidomide

Autoři: Mgr. Monika Běličková; prof. MUDr. Jaroslav Čermák, CSc.; Kamila Fejglova; Ing. Michaela Dostálová-Merkerová, Ph.D.; doc. MUDr. Radana Neuwirtová, CSc.; MUDr. Miroslav Čaniga; MUDr. Magda Šišková, CSc.; MUDr. Libor Červinek, Ph.D.; doc. MUDr. Anna Jonášová, Ph.D.
Číslo abstraktu: 4641
Kategorie: Maligní lymfomy a leukémie

Disorders of Coagulation or Fibrinolysis

SeveN BleeP Registry – 5 Years Later: An Update

Autoři: MUDr. Jan Blatný, Ph.D.; Prasad Mathew; John Puetz; Mgr. Petra Ovesná, Ph.D.; Ing. Petr Brabec
Číslo abstraktu: 3651
Kategorie: Ostatní

Experimental Transplantation

Transplantation Window Created by Bone Marrow Irradiation and Its Closure

Autoři: Katarina Forgacova; RNDr. Luděk Šefc, CSc.; Jana Michalova; Bc. Filipp Savvulidi; Ko-Tung Chang; Prof. MUDr. Emanuel Nečas, DrSc.
Číslo abstraktu: 3713
Kategorie: Ostatní

Hematopoietic Stem Cells Survive Warm Ischemia and the Bone Marrow Upregulates a Significant Number of Genes

Autoři: Jana Michalova; RNDr. Luděk Šefc, CSc.; Bc. Filipp Savvulidi; Katarina Forgacova; Katerina Faltusova; Ko-Tung Chang; Prof. MUDr. Emanuel Nečas, DrSc.
Číslo abstraktu: 4694
Kategorie: Ostatní

Granulocytes, Monocytes and Macrophages

The Oncogenic Mir-17-92 MicroRNA Cluster Is Inhibited by EGR2 During Macrophage Differentiation Via JARID1b-Mediated Histone 3 Lysine 4 Demethylation

Autoři: Mgr. Vít Pospíšil; Mgr. Karina Vargová, Ph.D.; Mgr. Juraj Kokavec; Jana Rybářová; Bc. Filipp Savvulidi; Prof. MUDr. Emanuel Nečas, DrSc.; Peter Laslo; Jiri Zavadil, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 390
Kategorie: Maligní lymfomy a leukémie

Hematopoiesis

Selective Persistence of Distinct Stem/B Leukaemic Stem Cells In Childhood Acute Lymphoblastic Leukaemia In Clinical Remission

Autoři: Christoph Lutz; Petter Woll; Anders Castor; Helen Ferry; Christina Jensen; Joanne Green; Helene Dreau; Michael Lutteropp; M.D. Anna Schuh, Ph.D.; Georgina Hall; Chris Mitchell; prof. MUDr. Jan Zuna, Ph.D.; Veronica Buckle; Sten Eirik W Jacobsen; Tariq Enver
Číslo abstraktu: 1585
Kategorie: Maligní lymfomy a leukémie

Hematopoietic Stem and Progenitor Biology

Mobilization with Cyclophosphamide Shifts Hematopoiesis From the Bone Marrow to the Spleen In Mouse

Autoři: RNDr. Luděk Šefc, CSc.; Ko-Tung Chang; Mgr. Viktor Sýkora; Prof. MUDr. Emanuel Nečas, DrSc.
Číslo abstraktu: 1590
Kategorie: Maligní lymfomy a leukémie

Chronic Lymphocytic Leukemia

Clonal Evolution of Malignant Populations In Potentially Biclonal Chronic Lymphocytic Leukemia Patients

Autoři: Mgr. Karla Plevová, Ph.D.; Mgr. Hana Skuhrová Francová; MvDr. Boris Tichý, Ph.D.; RNDr. Jitka Malčíková, Ph.D.; Mgr. Šárka Pavlová, PhD; Mgr. Ondřej Horký; Ing. Olga Stehliková; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. RNDr. Šárka Pospíšilová, Ph.D.
Číslo abstraktu: 2412
Kategorie: Maligní lymfomy a leukémie

Low-Dose Fludarabine and Cyclophosphamide Combined with Rituximab In the Treatment of Elderly/Comorbid Patients with chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): Preliminary Results of Project Q-Lite by Czech CLL Study Group

Autoři: MUDr. Lukáš Smolej, Ph.D.; MUDr. Martin Špaček; MUDr. Yvona Brychtová, Ph.D.; MUDr. David Belada, Ph.D.; MUDr. Jiří Schwarz, CSc.; prof. MUDr. Michael Doubek, Ph.D.; MUDr. Monika Motyčková; MUDr. Eduard Cmunt, CSc.; MUDr. Peter Rohoň; Ing. Kateřina Klásková; doc. MUDr. Tomáš Kozák, Ph.D., MBA
Číslo abstraktu: 2466
Kategorie: Maligní lymfomy a leukémie

Active Chromatin Structure near MYB Occupancy at the Mir-155 Host Gene Promoter Coincides with Increased Mir-155 and MYB Levels In Chronic Lymphocytic Leukemia

Autoři: Doc. MUDr. Tomáš Stopka, Ph.D.; Mgr. Karina Vargová, Ph.D.; Mgr. Nikola Čuřík, Ph.D.; Mgr. Pavel Burda, Ph.D.; Mgr. Petra Vlčková (Bašová); Mgr. Vít Pospíšil; Mgr. Vojtěch Kulvait; Bc. Filipp Savvulidi; Prof. MUDr. Emanuel Nečas, DrSc.; MUDr. Adéla Berková; MUDr. Petra Obrtlíková, Ph.D.; MUDr. Josef Karban, CSc.; Prof. MUDr. Marek Trněný, CSc.; Jiri Zavadil, Ph.D.
Číslo abstraktu: 3589
Kategorie: Maligní lymfomy a leukémie

The Composition of the B Cell Receptor Repertoire In 7428 Cases of Chronic Lymphocytic Leukemia: One Third Stereotyped, Two Thirds Heterogeneous - What Does This Mean?

Autoři: Andreas Agathaggelidis; Dr. Nikos Darzentas, PhD; Anastasia Hadzidimitriou; Xavier Brochet; Fiona Murray; M.D. Xiao-Jie Yan, Ph.D.; Zadie Davis; Ellen van Gastel; Cristina Tresoldi; Charles Chiyuan Chu, Ph.D.; Nicola Cahill; Veronique Giudicelli; MvDr. Boris Tichý, Ph.D.; Lone Bredo Pedersen; MD Letizia Foroni, PhD; Paola Francia di Celle; Agnieszka Janus; M.D. Karin Ekström Smedby, Ph.D.; Dr. Achilles Anagnostopoulos; MD Helene Merle-Béral, PhD; Nikolaos Laoutaris; Prof. MD Gunnar Juliusson, PhD; prof. RNDr. Šárka Pospíšilová, Ph.D.; MD Jesper Jurlander, PhD; Athanasios Tsaftaris; Prof. Marie-Paule Lefranc; Dr. Anton W. (Ton) Langerak ; Prof. David Graham Oscier; MD Nicholas Chiorazzi; MD Chrysoula Belessi; MD Frederic Davi, PhD; Prof. MD Richard Rosenquist (Brandell), PhD; M.D. Paolo Ghia, Ph.D.; MD Kostas Stamatopoulos
Číslo abstraktu: 43
Kategorie: Maligní lymfomy a leukémie

Cyclin D1 mRNA Expression In CLL: a Pilot Study

Autoři: MUDr. Heidi Móciková, Ph.D.; MUDr. Soňa Peková, Ph.D.; Lenka Zejsková; MUDr. Martin Špaček; doc. MUDr. Tomáš Kozák, Ph.D., MBA
Číslo abstraktu: 4619
Kategorie: Maligní lymfomy a leukémie

Rituximab In Combination with High-Dose Dexamethasone: An Effective Treatment Option for Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia

Autoři: prof. MUDr. Michael Doubek, Ph.D.; MUDr. Martin Šimkovič; MUDr. Anna Panovská; MUDr. Monika Hrudková; MUDr. David Belada, Ph.D.; MUDr. Yvona Brychtová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; MUDr. Lukáš Smolej, Ph.D.
Číslo abstraktu: 4629
Kategorie: Maligní lymfomy a leukémie

Final Analysis From the International Trial of Single-Agent Ofatumumab In Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia

Autoři: MD William G. Wierda, PhD; MD Thomas J. Kipps, PhD; prof. MUDr. Jiří Mayer, CSc.; MD Tadeusz Robak, PhD.; Prof. M.D. Martin John Swinnerton Dyer; Richard R. Furman; Peter Hillmen, M.B. ChB, Ph.D.; MD Stephan Stilgenbauer; Catherine D. Williams, MBBS, MRCP, FRCPath; Prof. MUDr. Marek Trněný, CSc.; Guillaume Cartron; MD Francisco J. Hernandez-Ilizaliturri; MBBS, MD Swaminathan Padmanabhan
Číslo abstraktu: 921
Kategorie: Maligní lymfomy a leukémie

Chronic Myeloid Leukemia

Interferon Alpha Treated Patients with Chronic Myeloid Leukemia (CML) In Prolonged Complete Remission Have Increased Numbers of NK-Cells and Clonal Gamma-Delta T-Cells, and a Distinct Plasma Cytokine Profile

Autoři: Anna Kreutzman, PhD; MUDr. Peter Rohoň; prof. MUDr. Edgar Faber, CSc.; prof. MUDr. Karel Indrák, DrSc.; Vesa Juvonen; MD Veli Kairisto, PhD; MUDr. Jaroslava Voglová; Marjatta Sinisalo; MUDr. Emilia Flochová; MD Petteri Arstila, PhD; MD Kimmo Porkka, PhD; MD Satu Mustjoki, PhD
Číslo abstraktu: 1201
Kategorie: Maligní lymfomy a leukémie

The Outcome of Unselected Patients with Chronic Myeloid Leukemia (CML) In Chronic Phase (CP) Treated with Imatinib In the First Line and the Prognostic Value of ELN Defined Responses – Population Based Analysis of 458 Patients Treated Between 2003–20

Autoři: MUDr. Hana Klamová, CSc.; MUDr. Daniela Žáčková, Ph.D.; prof. MUDr. Edgar Faber, CSc.; MUDr. Kateřina Steinerová; MUDr. Michal Karas; MUDr. Eva Demečková; MUDr. Jaroslava Voglová; MUDr. Ľudmila Demitrovičová; prof. MUDr. Elena Tóthová, CSc.; MUDr. Juraj Chudej, Ph.D.; MUDr. Imrich Markuljak; doc. MUDr. Tomáš Kozák, Ph.D., MBA; MUDr. Eduard Cmunt, CSc.; Prof. RNDr. Mgr. Marie Jarošová, CSc.; Mgr. Kateřina Machová (Poláková), Ph.D.
Číslo abstraktu: 1239
Kategorie: Maligní lymfomy a leukémie

Minimal Residual Resistance In CML: Stable BCR-ABL Gene Expression at Levels 0.01–0.1% (IS) In the Consecutive Samples May Be Associated with BCR-ABL Mutation Development and MMoR Lost In a Small Number of Tyrosine Kinase Inhibitor Responders

Autoři: Mgr. Kateřina Machová (Poláková), Ph.D.; Mgr. Sylvie Nádvorniková; Mgr. Karla Zemanová, Ph.D.; MUDr. Hana Klamová, CSc.; Mgr. Tomáš Jurček; Ing. Dana Dvořáková, CSc.; MUDr. Daniela Žáčková, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; Prof. MUDr. Marek Trněný, CSc.; RNDr. Jana Moravcová, CSc.
Číslo abstraktu: 3419
Kategorie: Maligní lymfomy a leukémie

Dasatinib Promotes BIM Dependent Apoptosis Via MEK/ERK without Need for Permanent BCR-ABL Inhibition

Autoři: Mgr. Pavel Šimara, Ph.D.; Mgr. Stanislav Stejskal; Martina Peterkova; RNDr. Irena Koutná, Ph.D.; Prof. MUDr. Zdeněk Ráčil, Ph.D.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 4472
Kategorie: Maligní lymfomy a leukémie

Stability of Conversion Factors for BCR-ABL Monitoring -– Implications for the Frequency of Validation Rounds

Autoři: Prof. Dr. med. Martin C. Müller; Umang Munjal; Philipp Erben; Prof. MD Thomas Lion, PhD; Gerlinde Mitterbauer-Hohendanner, MD; Dr. Hakim El Housni, Sc.; Prof. Dr. Nancy Boeckx; MD Renata Zadro, PhD.; prof. MUDr. Jiří Mayer, CSc.; MUDr. Peter Rohoň; Mgr. Jana Karavdič (Rulcová); Lykke Grubach; MD Kadri Raudsepp; MD Veli Kairisto, PhD; M.D. Francois-Xavier Mahon, Ph.D.; Prof. Claude Preudhomme, MD
Číslo abstraktu: 893
Kategorie: Maligní lymfomy a leukémie

Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Autoři: MD Thomas Ernst; Dr. Feng Lin, PhD.; Helen E White, PhD.; MD Paul La Rosée; Prof. MD Thomas Lion, PhD; Gerlinde Mitterbauer-Hohendanner, MD; MD Peter Vandenberghe (Vandenberge), Ph.D.; MD Renata Zadro, PhD.; Mgr. Kateřina Machová (Poláková), Ph.D.; Mgr. Radek Plachý, Ph.D.; M.Sci. Charlotte Guldborg Nyvold, Ph.D.; Tuija Lundán, PhD.; Jean-Michel Cayuela, PhD.; MD Thoralf Lange; Prof. Dr. med. Martin C. Müller; MD Katerina Zoi, Ph.D.; MD Hajnalka Andrikovics, PhD.; MD Tali Tohami, Ph.D.; MD Fabrizio Pane; Simona Soverini; Francesca Arruga, Ph.D.; Lene Eggen, Ph.D.; MD Tomasz Sacha; MD Joana Diamond, PhD.; MD Rodica Talmaci, Ph.D.; MD Tadej Pajic, PhD.; MD Dolors Colomer, PhD.; Monica Hermanson, PhD; Elisabeth Oppliger Leibundgut, PharmD; Peter (J.M.) Valk, PhD.; prof. MD Ugur Ozbek, PhD.; Dr. Gareth Gerrard, PhD.; MD Giuseppe Saglio, PhD.; MD Andreas Hochhaus; Prof. Nicholas Cross, PhD, FRCPath
Číslo abstraktu: 894
Kategorie: Maligní lymfomy a leukémie

Leukemias

Prognostic Impact of Ikaros (IKZF1) Gene Alterations In Childhood ALL Treated with ALL IC-BFM 2002 Protocol: A Comparison of Gene Expression and Genomic-Based Methods

Autoři: MUDr. Jana Volejníková; MUDr. Ester Mejstříková, Ph.D.; MUDr. Karel Švojgr, Ph.D.; prof. MUDr. Jan Starý, DrSc.; Prof.MUDr. Jan Trka, Ph.D.; MUDr. Eva Froňková, Ph.D.
Číslo abstraktu: 1656
Kategorie: Maligní lymfomy a leukémie

WT1 Expression at the Diagnosis of Childhood AML Has No Prognostic Value but Corresponds with the Biological Characteristics of Leukemic Cells - Results From European Multicenter Study

Autoři: Mgr. Karolina Škvárová Kramarzová, Ph.D.; MD Andre Willasch, PhD; Dr. Bernd Gruhn; MUDr. Ludmila Boublíková, Ph.D.; Hermann Kreyenberg; Eva Rettinger; Martin Zimmermann, Ph.D.; prof. MUDr. Jan Starý, DrSc.; MD Dirk Reinhardt, PhD; MD Ursula Creutzig, PhD; Prof. MD Andrea Pession; Giovanni (Gianni) Cazzaniga, PhD; Tiziana Coliva; Peter Bader; Prof.MUDr. Jan Trka, Ph.D.
Číslo abstraktu: 1684
Kategorie: Maligní lymfomy a leukémie

B Precursor ALL Subset with Aberrant CD2 Expression and a Specific Predisposition to Early Monocytic Transdifferentiation

Autoři: MUDr. Ester Mejstříková, Ph.D.; MUDr. Lucie Slámová; MUDr. Eva Froňková, Ph.D.; prof. MUDr. Jan Zuna, Ph.D.; MD Jean-Pierre Bourquin, PhD; MUDr. Elena Vodičková; Ing. Kateřina Mužíková; Doc.RNDr. Zuzana Zemanová, CSc.; Vendula Pelková (Macečková); Frederik Van Delft; prof. MUDr. Tomáš Kalina, Ph.D.; Mgr. Karel Fišer, Ph.D.; MUDr. Petr Smíšek; Prof.MUDr. Jan Trka, Ph.D.; prof. MUDr. Jan Starý, DrSc.; Prof. MUDr. Ondřej Hrušák, Ph.D.
Číslo abstraktu: 1708
Kategorie: Maligní lymfomy a leukémie

C20orf94 deletion Is Strongly Associated with TEL/AML1 Rearrangement and Links Illegitimate V(D)J Recombination with Gender Bias In Childhood Acute Lymphoblastic Leukemia

Autoři: Barbara Meissner; Thies Bartram; Dr. Cornelia Eckert, PhD; Dr. phil. nat. Rolf Koehler, PhD; Prof.MUDr. Jan Trka, Ph.D.; Mgr. Ivana Heřmanová; Petra Breithaupt; Martin Zimmermann, Ph.D.; MD Gunnar Cario; MD André Schrauder; MD Anja Möricke; Giovanni (Gianni) Cazzaniga, PhD; Dr. Geertruy (Gertruuy) Te Kronnie, PhD; Renate Kirschner-Schwabe; Arend von Sta
Číslo abstraktu: 1718
Kategorie: Maligní lymfomy a leukémie

Prognostic Value of Immunophenotype In Infant ALL – Results of the INTERFANT99 Study

Autoři: MD Tomasz Szczepanski, PhD; Lukasz Sedek, PhD; Paola de Lorenzo, PhD; MD Martin Schrappe; MD Richard Ratei; Goran Gustaffson; Prof. Liisa Hovi; prof. MUDr. Ajay J. Vora, MD, FRCP, FRCPath; MD Giuseppe Basso; MD Andrea Biondi; Jorge Gabriel Rossi, Ph.D.; MD Maria Sara Felice, Ph.D.; Elisabeth van Wering; Thierry Leblanc; Gritta Janka; Ester Mej
Číslo abstraktu: 2700
Kategorie: Maligní lymfomy a leukémie

Myeloid Leukemia of Down Syndrome: The Results of An International Retrospective Study

Autoři: Marjolein Blink; MD Marry M. van den Heuvel-Eibrink, PhD; MD Valerie de Haas, Ph.D.; Prof. MD Henrik Hasle; Maureen OBrien; MD Batia Stark; Julie Tandonnet; Prof. MD Andrea Pession; MUDr. Kateřina Toušovská, Ph.D.; Daniel K.L. Cheuk; Kazuko Kudo; MD Takashi Taga; MD Jeffrey Rubnitz, PhD; Irén Haltrich; MD Walentyna Balwierz, PhD
Číslo abstraktu: 2718
Kategorie: Maligní lymfomy a leukémie

In Vitro Sensitivity to Tyrosine Kinase Inhibitors Is One of Possible Predictive Parameters for Therapy Switch In Patients with Chronic Myeloid Leukemia

Autoři: RNDr. Markéta Žáčková, Ph.D.; Mgr. Tereza Lopotová; RNDr. Zuzana Ondráčková; MUDr. Hana Klamová, CSc.; RNDr. Jana Moravcová, CSc.
Číslo abstraktu: 2747
Kategorie: Maligní lymfomy a leukémie

Expression Analysis of WT1 Splicing Variants In CML and AML: –5/+KTS as a Novel Candidate for Early Marker of Relapse

Autoři: Mgr. Tereza Lopotová; Mgr. Jaroslav Polák; MUDr. Hana Klamová, CSc.; MUDr. Jiří Schwarz, CSc.; RNDr. Jana Moravcová, CSc.
Číslo abstraktu: 2749
Kategorie: Maligní lymfomy a leukémie

Clinical Impact of Additional Cytogenetic Aberrations and Complex Karyotype In Pediatric 11q23/MLL-Rearranged AML: Results from an International Retrospective Study

Autoři: MD Eva A Coenen; Susana C. Raimondi; Jochen Harbott; Martin Zimmermann, Ph.D.; Brian V Balgobind; Prof. Todd Allen Alonzo, PhD; MD Anne Auvrignon; H.Berna Beverloo, PhD; Myron Chang; MD Ursula Creutzig, PhD; Prof. MD Michael Dworzak; Erik Forestier; Brenda Gibson; Prof. MD Henrik Hasle; PhD Christine J. Harrison, FRCPath
Číslo abstraktu: 762
Kategorie: Maligní lymfomy a leukémie

Lymphoma

Randomised Intergroup Trial of First line Treatment for young Low-Risk Patients (

Autoři: MD Michael Pfreundschuh; Evelyn Kuhnt; Lorenz Trümper; Anders Osterborg; Prof. MUDr. Marek Trněný, CSc.; MD Lois E. Shepherd; Devinder S Gill, MB ChB, MRCP (UK), FRCPath (Lond); MD Jan Andrzej Walewski, Ph.D.; Ruth Pettengel, MBchB, FRACP, PhD; M.D. Ulrich Jäger; Pier Luigi Zinzani; MD Ofer Shpilberg, MPH; Stein Kvaloy; Dr.Med Mads Hansen; Rolf A. Stahel; MD Noel-Jean Milpied, Ph.D.
Číslo abstraktu: 111
Kategorie: Maligní lymfomy a leukémie

Updated Results of the PRIMA Study Confirms the Benefit of 2-Years Rituximab Maintenance In Follicular Lymphoma Patients Responding to Immunochemotherapy

Autoři: MD Gilles Andre Salles, PhD; MBBS John V. Catalano, FRACP FRCPA; MD Pierre Feugier, PhD; MD Fritz C. Offner, PhD; MD Reda Bouabdallah; MD Dolores Caballero; MD Pauline Brice; MD Lars Moller Pedersen, PhD; Corinne Haioun; MUDr. David Belada, Ph.D.; Alain Delmer; M.D. David Simpson, FRACP, FRCPA, MBChB; MD Herve Tilly; prof. Sirpa Leppä; Pierre Soubeyran; Anton Hagenbeek
Číslo abstraktu: 1788
Kategorie: Maligní lymfomy a leukémie

The Role of the Rituximab Partner Chemotherapy Regimen In Young Patients with Good-Prognosis Diffuse Large B-Cell Lymphoma (DLBCL): Results of the 6-Year Follow-up of the Mint Study of the Mabthera International Trial (MInT) Group

Autoři: Niels Murawski; Evelyn Kuhnt; Sandra Grass; MD Wolfgang Hiddemann; Eva Cavallin-Stahl; MD Georg Hess; MD Mathias Witzens-Harig; MUDr. Ingrid Vášová; M.D. Ulrich Jäger; Michal Osowiecki; Scott North; Ruth Pettengel, MBchB, FRACP, PhD; Viola Pöschel; Markus Löffler; MD Michael Pfreundschuh
Číslo abstraktu: 2826
Kategorie: Maligní lymfomy a leukémie

Median Absolute Lymphocyte Count Independently Predicts Survival of Elderly Patients with Diffuse Large B-Cell Lymphoma Treated with R-Chemotherapy: Analysis of 651 Patients Included In the Czech Lymphoma Project

Autoři: MUDr. Vít Procházka, Ph.D.; Prof. MUDr. Marek Trněný, CSc.; MUDr. David Šálek, Ph.D.; MUDr. David Belada, Ph.D.; doc. MUDr. Tomáš Kozák, Ph.D., MBA; doc. MUDr. Tomáš Papajík, CSc.; MUDr. Robert Pytlík, Ph.D.; MUDr. Ingrid Vášová; MUDr. Alice Sýkorová, Ph.D.; MUDr. Milada Jankovská; MUDr. Kateřina Kubáčková; MUDr. Martin Brejcha; MUDr. Milan Matuška, Ph.D.; MUDr. Katarína Petráková, Ph.D.; MUDr. Jan Pirnos; MUDr. Jana Nepomucká, CSc.; MUDr. David Starostka; MUDr. Milan Lysý; MUDr. Vít Campr, Ph.D.; Doc. MUDr. Ludmila Boudová, Ph.D.; Mgr. Marie Trnková; ing. Markéta Petrová, 1. LF UK a VFN
Číslo abstraktu: 2882
Kategorie: Maligní lymfomy a leukémie

Assessment of Residual Bulky Tumor Using FDG-PET In Patients with Advanced-Stage Hodgkin Lymphoma After Completion of Chemotherapy: Final Report of the GHSG HD15 Trial

Autoři: Prof. MD Andreas Engert; MD Carsten Kobe; MUDr. Jana Marková; Heinz Haverkamp; MD Peter Borchmann, PhD; Felicitas Hitz; Jose Zijlstra, MD; Hans Eich; Rolf Peter Mueller; MD Markus Dietlein; MD Volker Diehl
Číslo abstraktu: 764
Kategorie: Maligní lymfomy a leukémie

Dose-Escalation with BEACOPP Escalated Is Superior to ABVD In the Combined-Modality Treatment of Early Unfavorable Hodgkin Lymphoma: Final Analysis of the German Hodgkin Study Group (GHSG) HD14 Trial

Autoři: Prof. MD Andreas Engert; MD Peter Borchmann, PhD; Annette Pluetschow; MD Bastian von Tresckow; MUDr. Jana Marková; Felicitas Hitz; MUDr. Zdeněk Král, Ph.D.; MD Richard Greil, Ph.D.; Prof. Dr. Max S Topp; Matthias Villalobos; Jose Zijlstra, MD; M.D. Martin Soekler (Sökler); Prof. Harald Stein; MD Hans Theodor Eich; Rolf-Peter Muell
Číslo abstraktu: 765
Kategorie: Maligní lymfomy a leukémie

Result of FDG PET-CT Imaging After Immunochemotherapy Induction Is a Powerful and Independent Prognostic Indicator of Outcome for Patients with Follicular Lymphoma: An Analysis From the PRIMA Study

Autoři: Judith Trotman; Marion Fournier; MD Thierry Lamy; Dr. Jane A Estell, MBBS, FRCPA, FRACP; M.D. Anne Sonet, Ph.D.; MD Herve Tilly; Didier Decaudin; Jean Gabarre; Prof. John Francis Seymour, MD, PhD, MBBS, FRACP; Etienne Garin; Cecily Forsyth; Michael Fulham; Thierry Vander Borght; MD Ofer Shpilberg, MPH; MD Gilles Andre Salles, PhD
Číslo abstraktu: 855
Kategorie: Maligní lymfomy a leukémie

A Phase 3 Trial Comparing Bortezomib Plus Rituximab with Rituximab Alone In Patients with Relapsed, Rituximab-Naive or -Sensitive, Follicular Lymphoma

Autoři: MD Bertrand Coiffier; Evgenii Osmanov; Xiaonan Hong; Adriana Scheliga; prof. MUDr. Jiří Mayer, CSc.; MD Fritz C. Offner, PhD; prof. Simon A. Rule; Adriana Teixeira; MD Jan Andrzej Walewski, Ph.D.; MD Michael Crump, FRCPC; MD Ofer Shpilberg, MPH; Robert Hermann; Sudha Parasuraman; Eugene Zhu; Christopher Enny; T. Panteli
Číslo abstraktu: 857
Kategorie: Maligní lymfomy a leukémie

Molecular Pharmacology

Roscovitine Sensitizes Leukemia and Lymphoma Cells to TRAIL-Induced Apoptosis and Enhances Cell-Mediated Cytotoxicity

Autoři: MUDr. Jan Molinský; MUDr. Marie Marková, CSc.; MUDr. Magdalena Klánová; Michal Koc; Lenka Beranova; RNDr. Ladislav Anděra, CSc.; Zdenka Ludvikova; Martina Bohmova; Zdenka Gasova; Prof. MUDr. Marek Trněný, CSc.; Prof. MUDr. Emanuel Nečas, DrSc.; Doc.MUDr. Jan Živný, Ph.D.; prof. MUDr. Pavel Klener, DrSc.
Číslo abstraktu: 596
Kategorie: Maligní lymfomy a leukémie

Myelodysplastic Syndromes

5-Azacytidine and G-CSF Derepressed Chromatin Structure of PU.1 and Its Targets Cebpa and Cbfb In Myelodysplastic Syndrome (MDS)

Autoři: Doc. MUDr. Tomáš Stopka, Ph.D.; Mgr. Pavel Burda, Ph.D.; Mgr. Petra Vlčková (Bašová); Mgr. Karina Vargová, Ph.D.; Mgr. Nikola Čuřík, Ph.D.; doc. MUDr. Anna Jonášová, Ph.D.; Prof. MUDr. Marek Trněný, CSc.
Číslo abstraktu: 124
Kategorie: Myelodysplastický syndrom

The Population-Based "real world" of Low Risk Myelodysplastic Syndromes; Second Interim Analysis of the European LeukemiaNet MDS Registry at 800 Registered New Patients

Autoři: MD David Bowen, Ph.D.; Alexandra Smith; Jackie Droste; MD Pierre Fenaux, PhD; Dr. Argyris Symeonidis, Ph.D.; MD Eva Hellström-Lindberg; MD Guillermo F Sanz, PhD; prof. MUDr. Jaroslav Čermák, CSc.; Otilia Georgescu; MD Ulrich Germing; Marius MacKenzie; MD Reinhard Stauder; MD Odile Beyne Rauzy, PhD; MD Luca Malcovati; MD Theo de Witte, PhD
Číslo abstraktu: 1867
Kategorie: Myelodysplastický syndrom

Disease-Management of Low- and Intermediate-1 Risk Myelodysplastic Syndromes: Report on 800 Newly Diagnosed MDS Patients From the European LeukemiaNet MDS Registry

Autoři: MD Louise de Swart; Alexandra Smith; MD Pierre Fenaux, PhD; Dr. Argyris Symeonidis, Ph.D.; MD Eva Hellström-Lindberg; MD Guillermo F Sanz, PhD; prof. MUDr. Jaroslav Čermák, CSc.; Otilia Georgescu; MD Ulrich Germing; Marius MacKenzie; Odile Beyne-Rauzy; MD Luca Malcovati; MD Reinhard Stauder; Jackie Droste; David Bow
Číslo abstraktu: 2917
Kategorie: Myelodysplastický syndrom

Health-Related Quality of Life In Newly Diagnosed Low Risk and Intermediate-1 Risk MDS: Report on the First 683 Patients From the European LeukemiaNet Registry

Autoři: MD Reinhard Stauder; Alexandra Smith; MD Theo M. de Witte; Jackie Droste; MD Pierre Fenaux, PhD; Dr. Argyris Symeonidis, Ph.D.; MD Eva Hellström-Lindberg; MD Guillermo F Sanz, PhD; prof. MUDr. Jaroslav Čermák, CSc.; Otilia Georgescu; MD Ulrich Germing; Marius MacKenzie; Odile Beyne-Rauzy; MD Luca Malcovati; David Bow
Číslo abstraktu: 3999
Kategorie: Myelodysplastický syndrom

Refractory Cytopenia In Childhood (RCC) with Normal Karyotype Is Unlikely to Progress to Advanced MDS Under a Watch and Wait Strategy

Autoři: MD Shinsuke Hirabayashi; MD Brigitte Strahm; Stephan Schwarz; MD Marco Zecca; MD Markus Schmugge (Schmugge-Liner); Prof. MD Michael Dworzak; MD Marry M. van den Heuvel-Eibrink, PhD; Prof. MD Henrik Hasle; MD Barbara De Moerloose; prof. MUDr. Jan Starý, DrSc.; Dorota Wojcik; Ingrid Furlan; Prof. MD Franco Locatelli, PhD; MD Irith Baumann; Prof. MD Charlotte M. Niemeyer, PhD
Číslo abstraktu: 4007
Kategorie: Myelodysplastický syndrom

Combination Chemotherapy Leading In Advanced MDS Patients to a Rapid Clearence of Bone Marrow Blasts Prior Stem Cell transplantation (SCT) Is Superior to up-Front SCT Even with Intensified Conditioning for Long-Term Survival

Autoři: prof. MUDr. Jaroslav Čermák, CSc.; MUDr. Antonín Vítek; MUDr. Markéta Marková-Šťastná, CSc.; prof. MUDr. Petr Cetkovský, Ph.D.
Číslo abstraktu: 4020
Kategorie: Myelodysplastický syndrom

Myeloma

Post-Approval Safety Study (PASS) of Lenalidomide Compared with Other Treatments In Patients with Relapsed or Refractory Multiple Myeloma: Evaluation of Peripheral Neuropathy In the First 1,011 Patients

Autoři: MD Michel Delforge, PhD; MD Igor W. Blau, Ph.D.; Miguel T. Hernandez; prof. MUDr. Roman Hájek, CSc.; Luciano Masini; MD Henk Lokhorst, PhD; Giacinto La Verde; MD Laurence Sanhes; Javier De La Rubia; Janine Collins; Barbara Rosettani; Nancy A Brandenburg; Renato Zambello
Číslo abstraktu: 1939
Kategorie: Mnohočetný myelom

Vorinostat Combined with Bortezomib In Patients with Relapsed or Relapsed and Refractory Multiple Myeloma: Update on the Vantage Study Program

Autoři: MD David Samuel diCapua Siegel, PhD; Sundar Jagannath; prof. MUDr. Roman Hájek, CSc.; Meletios Athanasios Dimopoulos, MD; MD Sung-Soo Yoon, PhD; Prof. MD Sagar Lonial; M.D. Jacob P. Laubach; MD Thorsten Graef, PhD; Dina Pietrangelo; Lisa Lupinacci; David Reiser; MD Kenneth C. Anderson
Číslo abstraktu: 1952
Kategorie: Mnohočetný myelom

Flow Cytometric Phenotyping and Analysis of CD8 Regulatory and Suppressor Cells In Multiple Myeloma

Autoři: Mgr. Karthick Raja Muthu Raja; Mgr. Lucie Říhová, PhD.; RNDr. Ivana Burešová; prof. MUDr. Roman Hájek, CSc.; Prof. MUDr. Jaroslav Michálek, Ph.D.
Číslo abstraktu: 2947
Kategorie: Mnohočetný myelom

Association Study of Ploidy Category with Mitotic Disruption In Multiple Myeloma

Autoři: MUDr. Elena Dementyeva; MUDr. Fedor Kryukov; doc. RNDr. Sabina Ševčíková, Ph.D.; Mgr. Pavel Němec; Mgr. Jan Smetana; RNDr. Henrieta Grešliková; Mgr. Romana Zaoralová; RNDr. Ivana Burešová; prof. MUDr. Miroslav Penka, CSc.; Prof.RNDr. Petr Kuglík, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 2952
Kategorie: Mnohočetný myelom

Occurrence of Chromosomal Abnormalities In Bone Marrow CD14+ monocytes of Multiple Myeloma Patients

Autoři: Mgr. Hana Šváchová; RNDr. Henrieta Grešliková; Mgr. Aneta Mikulášová; Mgr. Kristina Beránková; Mgr. Pavel Němec; prof. MUDr. Jiří Mayer, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 2968
Kategorie: Mnohočetný myelom

Bortezomib(Velcade®)-Thalidomide-Dexamethasone (VTD) Is Superior to Thalidomide-Dexamethasone (TD) In Patients with Multiple Myeloma (MM) Progressing or Relapsing After Autologous Transplantation

Autoři: MD Laurent Garderet; Simona Iacobelli, Ph.D.; Prof. MD Philippe Moreau; MD Mamoun Dib; MD Denis Caillot; MD Dietger W Niederwieser; MD Tamas Masszi, PhD; MD Jean Fontan; MD Mauricette Michallet, Ph.D.; Alois Gratwohl; Dr. Giuseppe Milone; MD Chantal Doyen; Brigitte Pegourie; prof. MUDr. Roman Hájek, CSc.; Philippe Casassus
Číslo abstraktu: 3043
Kategorie: Mnohočetný myelom

Phenotypic Analysis of CD19+ Subsets In Monoclonal Gammopathy Patients

Autoři: Mgr. Lucie Říhová, PhD.; Mgr. Pavla Všianská; Ing. Tamara Varmužová; RNDr. Ivana Burešová; Mgr. Karthick Raja Muthu Raja; prof. MUDr. Miroslav Penka, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 4998
Kategorie: Mnohočetný myelom

Similar Efficacy of Thalidomide-Based and Bortezomib-Based Regimens In the First Relapse of 209 Multiple Myeloma Patients Previously Untreated with Novel Drugs

Autoři: Prof. MUDr. Marta Krejčí, Ph.D.; MUDr. Evžen Gregora; Prof.MUDr. Ivan Špička, PhD; MUDr. Jan Straub; MUDr. Jiří Minařík, Ph.D. ; prof. MUDr. Zdeněk Adam, CSc.; MUDr. Andrea Křivanová, Ph.D.; prof. MUDr. Luděk Pour, Ph.D.; MUDr. Lenka Zahradová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.; prof. MUDr. Roman Hájek, CSc.
Číslo abstraktu: 5027
Kategorie: Mnohočetný myelom

A Phase 3 Study Evaluating the Efficacy and Safety of Lenalidomide Combined with Melphalan and Prednisone In Patients ≥ 65 Years with Newly Diagnosed Multiple Myeloma (NDMM): Continuous Use of Lenalidomide Vs Fixed-Duration Regimens

Autoři: MD Antonio P. Palumbo; MD Michel Delforge, PhD; MBBS John V. Catalano, FRACP FRCPA; prof. MUDr. Roman Hájek, CSc.; MD Martin (H.) Kropff; MD Maria Teresa Petrucci; Zhinuan Yu, PhD; Lindsey Herbein; MD Jay M. Mei, PhD; Christian J. Jacques; Meletios Athanasios Dimopoulos, MD
Číslo abstraktu: 622
Kategorie: Mnohočetný myelom

Myeloproliferative Syndromes

Characterization of Chromosome 20q Deletions In Myeloproliferative Neoplasms Using Microarray Karyotyping and Next-Generation Sequencing

Autoři: Roland Jäger; Tiina Berg; Ashot Harutyunyan; Thorsten Klampfl; Francesco Passamonti; Elisa Rumi; Daniela Pietra, Ph.D.; Bettina Gisslinger; Damla Olcaydu; prof. MUDr. Miroslav Penka, CSc.; MD Heinz Gisslinger; M.D. Mario Cazzola; Robert Kralovics, PhD
Číslo abstraktu: 4099
Kategorie: Maligní lymfomy a leukémie

Outcome of Refractory Anemia with Ringed Sideroblasts Associated with Marked Thrombocytosis (RARS-T) In a Large Cohort of Patients

Autoři: MD Francois Girodon, PhD; Julien Broseus; Lourdes Florensa; Esther Zipperer; Prof. Dr. Susanne Schnittger, PhD; MD Luca Malcovati; Steven Richebourg; MD Eric Lippert, PhD; prof. MUDr. Jaroslav Čermák, CSc.; Dr. Jyoti Nangalia; Morgane Mounier; Jose Maria Raya; MD Norbert Gattermann; MD Torsten Haferlach; M.D. Mario Cazzola
Číslo abstraktu: 4113
Kategorie: Maligní lymfomy a leukémie

Long-Term Experience with Anagrelide (Thromboreductin®) In the Treatment of Essential Thrombocythemia: Data from an International Registry

Autoři: MD Michael Steurer; MD Heinz Gisslinger; prof. MUDr. Miroslav Penka, CSc.; Siegfried Sormann; MUDr. Jiří Schwarz, CSc.; prof. MUDr. Elena Tóthová, CSc.; Prof. MUDr. Mikuláš Hrubiško, Ph.D.; MD Andrzej Hellmann, Ph.D.; Maria Podolak-Dawidziak; Petro E. Petrides
Číslo abstraktu: 5064
Kategorie: Maligní lymfomy a leukémie

Non-Hodgkin Lymphoma

Interactions with the Microenvironment Protect Lymphoma B-Cells From Rituximab Induced Apoptosis and Could Represent a Therapeutic Target

Autoři: MUDr. Mgr. Marek Mráz, Ph.D.; Clive S. Zent; Amy K Church; Nisar A Baig; Dr. Diane F. Jelinek, Ph.D.; Wu Xiaosheng; prof. RNDr. Šárka Pospíšilová, Ph.D.; M.D. Stephen M. Ansell, Ph.D.; Anne J. Novak; Thomas E. Witzig; Grzegorz S. Nowakowski
Číslo abstraktu: 3115
Kategorie: Maligní lymfomy a leukémie

The Mystery of FDG-PET Avidity In Follicular Lymphoma. Does Microenvironment Play the Key Role?

Autoři: MvDr. Boris Tichý, Ph.D.; Mgr. Jana Šupíková; MUDr. Pavel Fabián, Ph.D.; Leos Kren; MUDr. Karol Bolčák; MUDr. David Šálek, Ph.D.; MUDr. Jozef Michalka; prof. RNDr. Šárka Pospíšilová, Ph.D.; prof. MUDr. Jiří Mayer, CSc.
Číslo abstraktu: 4138
Kategorie: Maligní lymfomy a leukémie

Platelet Activation and Biochemistry

Carbon Nanotubes Activate Store Operated Calcium Entry (SOCE) In Human Platelets Manifested by STIM1 Capping

Autoři: Silvia H. Lacerda; Jana Semberova; Dr. Ing. Karel Holada, Ph.D.; Olga Simakova; Jan Simak
Číslo abstraktu: 3190
Kategorie: Ostatní

Red Cells and Erythropoiesis, Structure and Function, Metabolism and Survival, Excluding Iron

Impairment of Erythropoiesis In Inbred Cellular Prion Protein Deficient Mice

Autoři: Hana Glierova; Martin Panigaj; Jana Semberova; Olga Janouskova; Eva Dvorakova; Doc.MUDr. Jan Živný, Ph.D.; Dr. Ing. Karel Holada, Ph.D.
Číslo abstraktu: 2032
Kategorie: Ostatní

Deletion of the Prion Protein Does not Affect Erythropoiesis in a Mouse Model of Beta-Thalassemia

Autoři: Monique Gelderman-Fuhrmann; John Farrell; Martin Panigaj; Dr. Ing. Karel Holada, Ph.D.; Jaroslav Vostal
Číslo abstraktu: 3213
Kategorie: Ostatní

Thalassemia and Globin Gene Regulation

ISWI Chromatin Remodeling ATPase Smarca5 (Snf2h) Is Required for Murine Erythroid Development and Globin Gene Regulation

Autoři: Mgr. Juraj Kokavec; Romit Majumdar; Mgr. Martina Kapalová; Mgr. Nikola Čuřík, Ph.D.; Bc. Filipp Savvulidi; Prof. MUDr. Emanuel Nečas, DrSc.; Arthur I. Skoultchi, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 2062
Kategorie: Ostatní

Decreased Rate of beta-GlobinL1 Allele Transcription Due to Intronic LINE-1 Insertion In the beta-Globin gene Is Associated with beta-globinL1 Promoter and Enhancer Hypermethylation Which Is Not Reverted by Decitabine

Autoři: Ing. Lucie Piterková; Mgr. Jana Kučerová; prof. MUDr. Karel Indrák, DrSc.; Doc.RNDr. Vladimír Divoký, Ph.D.
Číslo abstraktu: 2073
Kategorie: Ostatní

Smarca5 Regulates Ctcf Recruitment to Chromatin, Including to Regulatory Loci Involved In Control of Globin Gene Expression In Erythroleukemia

Autoři: Mgr. Martina Kapalová; Mgr. Juraj Kokavec; Mgr. Nikola Čuřík, Ph.D.; Mgr. Pavel Burda, Ph.D.; Arthur I. Skoultchi, Ph.D.; Doc. MUDr. Tomáš Stopka, Ph.D.
Číslo abstraktu: 5159
Kategorie: Maligní lymfomy a leukémie