Klin Onkol 2020; 33(2): 150-151. DOI: 10.14735/amko2020150.
Melatonin is a hormone produced primarily in the pineal gland and secreted in the dark. In addition to the pineal gland, the endometrium, lacrimal glands, kidney, liver, bronchus, retina, adrenal glands, ovary, gastrointestinal system, placenta, testis, thymus, mast cells, natural clays and leukocyte cells also synthesize melatonin. It is involved in the regulation of physiological functions, such as regulation of the endocrine rhythm, stimulation of the immune system, antigonadotropic effects, aging, sleep and heat regulation. It also has a wide range of biological effects due to its antioxidant, anti-inflammatory and anti-tumor activity [1–5].
