Klin Onkol 2016; 29(2): 133-138. DOI: 10.14735/amko2016133.
Background: Metastatic malignant melanoma belongs to a group of cancers with high mortality. In recent years, advances in our knowledge of the pathogenesis of melanoma and the
discovery of new drugs has resulted in signifi cant progress in the treatment of metastatic malignant melanoma patients. The development of resistance to these drugs, however, remains
a challenge. One way how to avoid resistance, or at least delay it, is to administer combination
therapy. Observation and Conclusion: This case study demonstrates that combination therapy with a BRAF and a MEK inhibitor can be used to successfully treat metastatic malignant melanoma patients and suggests they should be employed in therapeutic algorithms for patients
with metastatic malignant melanoma and BRAF gene mutations.
