Klin Onkol 2013; 26(Suppl): 22-28. DOI: 10.14735/amko2013S22.
Summary
Gastric carcinoma is a common malignant disease associated with an unfavorable prognosis in the case of late diagnosis. The most significant precancerous condition is chronic atrophic gastritis and intestinal metaplasia caused by Helicobacter pylori infection. These long-lasting changes may lead to formation of dysplastic precancerous lesions. Upper endoscopy and histologic examination of forceps biopsy specimens play a key role in the diagnosis of gastric precancerous conditions and lesions. Helicobacter pylori eradication therapy and endoscopic surveillance are main therapeutic modalities of gastric precancerous conditions. Localized precancerous lesions and early gastric neoplasia without the risk of lymphatic spread could be cured by means of endoscopic resection techniques.
