Implication of Bone Marrow Microenvironment in Pathogenesis of Multiple Myeloma

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Klin Onkol 2012; 25(4): 234-240. DOI: 10.14735/amko2012234.

Summary
Multiple myeloma is a hematooncological disease characterized by malignant proliferation of plasma cells. These cells accumulate in the bone marrow where they suppress physiological hematopoiesis; at the same time, these cells interact with a wide variety of cytokines, growth factors and adhesion molecules. It is obvious that the bone marrow microenvironment plays an important role in disease pathogenesis as well as treatment resistance.

http://dx.doi.org/10.14735/amko2012234

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