Klin Onkol 2011; 24(Suppl 1): 30-33. DOI: 10.14735/amko20111S30.
Summary
Multiple myeloma (MM) is a plasma cell (PC) disorder and associated with immune impairments. Flow cytometry based phenotyping and quantification of regulatory T cells (Tregs) enable to monitor the immune status of myeloma patients. Apart from enumeration of Tregs, functional characterization using proliferation or suppression assay adds key value in demonstrating the functional value of Tregs. Our study revealed that in MM patients Tregs are elevated compared to healthy subjects, which demonstrate the immune deregulation in MM.
