Klin Onkol 2008; 21(2): 45-52.
Head and neck squamous cell cancer (HNSCC) management is evolving rapidly. Approaches under exploration include induction chemotherapy, altered fractionation radiation with chemotherapy, intensity modulated radiation therapy (IMRT) and the use of biologically targeted drugs to enhance radiation. The goal of the new methods is improving the effectivity without increasing the toxicity. This article will focus maily on locally advanced HNSCC, which frequently remains a clinical challenge, review state-ofthe-art therapy and introduce promising novel terapies. For the future the incorporation of new agents, the use of novel biomarkers to accurately assess and individualize therapy, and expanded supportive care approaches will play an increasingly important role.
