Klin Onkol 2007; 20(5): 357-360.
Authors analyzed results of cytogenetic examinations with attention on detection of Philadelphia chromosome performed in patients with CML in the Prešov region in 1995-2004. Material and methods: Authors analyzed results of cytogenetic examinations perfor¬med in 72 samples of bone marrow cells in pacients with suspected diagnosis of CML. Results: Philadelphia chromosome in bone marrow cells of patients with suspected diagnosis CML in the Prešov region (1995-2004) was detected in 94,4% of cases . In one pati¬ent a complex translocation involing chromosomes 8, 9 and 22 was identified. One patient has showed extra numerical and structural chromosomal aberrations. Mosaic karyotype of the Ph chromosome was found in 5,9% of cases. Conclusion: The results of cytogenetic analyses confirm diagnostic and prognostic significance of Philadelphia chromosome in patients with clinical diagnosis CML. Conventional cytogenetic analysis remain the standard method for purposes of diagnosis, monitoring of the therapeutic response and minimal residual disease in patients with chronic myeloid leukemia.
