Klin Onkol 2007; 20(3): 260-263.
Cutaneous lymphomas co-expressing CD56 and CD30 are very rare. They share a clinicopathological overlap with natural killer (NK)/T-cell lymphomas and anaplastic large cell lymphomas, two entities with widely disparate clinical behavior. A case of an immunocompetent 57-year-old Czech woman with a rapidly growing, angiodestructive and neuroinvasive primary cutaneous anaplastic large cell lymphoma is described. The neoplastic population of large anaplastic CD30+ and CD56+ T-cells was masked by a massive admixture of histiocytes and neutrophils. The partially ulcerated and pus-secreting tumor involved the forehead and scalp and infiltrated the bone (clinical stage IAE). The treatment consisted of chemotherapy and autologous peripheral blood stem cell transplantation as a consolidation of complete remission in which the patient has remained for 6 years. This represents the first CD30+ and CD56+
primary skin lymphoma to be reported on the head. The presented case carries a remarkable combination of clinicopathological features of primary cutaneous anaplastic large cell lymphoma and NK/T-cell lymphoma.
