Klin Onkol 2006; 19(3): 186-193.
Summary
Backgrounds: Rectal adenocarcinoma is one of the most frequent tumors in the Czech Republic.
Design and Subjects: Retrospective study with the aim of evaluation of the results of treatment in 290 patients irradiated for rectal adenocarcinoma at the Department of Oncology and Radiotherapy, Charles University Medical School and Faculty Hospital in Hradec Kralove, in 1997-2004.
Methods and Results: Evaluated parameters: TNM stage, age, sex, histological grade, anatomic sublocalization of the tumor, pretreatment level of CEA, hemoglobin, leucocytes, thrombocytes, nadir of hemoglobin, nadir of leucocytes, nadir of thrombocytes during treatment, dose of radiation, number of fractions of radiotherapy, type of surgery, toxicity of radiotherapy, completion of planned schedule of treatment, evaluation of overall survival, number and localization of recurrences. In 75 patients were additionally immunohistochemically investigated EGFR, tumor infiltrating T lymphocytes, VEGF and oncoprotein p53.
Conclusions: There was no significant difference in overall survival, number or localization of recurrences when comparing different schedules of preoperative neodjuvant or postoperative adjuvant radiotherapy of locally advanced rectal cancer. Statistically significant worse overall survival was in inoperable patients treated with radiotherapy without surgery. Results of this study show correlations among expression of EGFR, tumor infiltrating T lymphocytes, VEGF and oncoprotein p53, laboratory, clinical-pathological characteristics of patients irradiated for rectal adenocarcinoma, independent prognostic factors for overall survival, disease free survival, and local recurrence.
