Klin Onkol 2004; 17(2): 61-63.
Summary: Radical cystectomy is the gold standard for invasive bladdet cancer, about half of patients develop distant metastases within two years after operation. Objectives of preoperative (neoadjuvant) chemotherapy in muscle invasive bladder cancer are eradication of micrometastasis and subsequent improvement of prognosis. However, response to the preoperative chemotherapy has been found to be an excellent prognostic factor ,and preservation of the bladder (complete preservation or partial cystectomy) is possible in selected cases with complete response.
