Klin Onkol 2002; 15(5): 189-191.
Abstract:
Backgrounds: Positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) is non-invasive imaging modality of great importance in oncology. No paper evaluates this method at breast cancer in condition of the Czech Republic.
Design and Subject: During the first 1.5 years of operation of PET Centre Prague, 105 investigations of breast cancer were carried out. Questionnaires were sent to all referring physicians; 62 questionnaires came back and were retrospectively evaluated.
Methods and Results: FDG-PET was acquired in 2D-mode with attenuation correction on dedicated scanner. 51 cases were referred for suspicious cancer recurrence. In this group FDG-PET changed therapy in 60 %; in remaining patients significantly less (12.5 %). When suspicious recurrence was coupled with growing levels of onco-markers, FDG-PET changed therapy in 72.7 %; in case of suspicious metastasis in 54.5 %. There was no significant difference in levels of CA 15-3 between groups of PET negative and positive results. Nevertheless, growing levels of CA 15-3 were coupled with significantly more frequent positive PET findings and changes of therapy in comparison to non-growing levels.
Conclusions: Involvement of FDG-PET in routine diagnostics at breast cancer seems to be very helpful at growing levels of CA 15-3 as well as at suspicious recurrence.
