Klin Onkol 2002; 15(4): 148-152.
Summary: MALT lymphomas, described by Isaacson and Wright in 1983 for the first time, was recognized by the REAL classification in 1994 as an independent low grade NHL lymphoma unit originating by malignant transformation of B-cells from the marginal zone of MALT system of peripheral extranodal tissue. At present lymphoma is defined on the base of specific morphological, phenotypic, genotypic and clinical symptoms. Its pulmonary localization is less frequent and two cases have been diagnosed in the course of the last ten years in the Teaching Hospital in Hradec Králové, one of them has remained still a diagnostic puzzle. A case of a 62 year-old patient suffering from progressing breathlessness, cough, weight loss, and night perspiration. CT lung examination verified affliction of all three lobes with exudate induction on the right.There was a suspicion of TBC or carcinoma. In the end pulmonary MALT lymphoma was diagnosed by explorative thoracotomy. At the beginning anaemia, increased LD level, beta2-microglobuline were revealed in laboratory finding. In disease staging dissemination was not proved. The basic schema of chemotherapy was applied. Complete disease restaging was carried out to reach complete remission. Conservation immunotherapy by interferon alpha started due to initial extends of the disease.
