Klin Onkol 2002; 15(3): 81-85.
Summary: Hematopoietic stem cells (HSC) are a subject of increasing interest because of their biological properties and potential medical importance. HSC are being increasingly used for treatment of various malignant and nonmalignant disorders. Identification and characterization of HSC is essential in order to achieve new developements in stem cell expansion and HSC transplantation. Identification of HSC is based on their biological, physical, immunole and functional properties. Recently several potent stimulating factors have been discovered e.g. FLT-3 ligand (FL) and Stem cell factor (SCF) that influence HSC fate. Better understanding of regulatory mechanisms in HSC biology may contribute to the developements of new terapeutical approaches of various so far incurable disorders.
