Summary: The malignant transformation of cell is caused by the accumulation of genetic defects. The characteristic feature of malignantly transformed cells is their inability today by apoptosis. Bcl-2 protein which is localized on intracellular membranes of cell is able to block the process of apoptosis via either heterodimers formation with another members of Bcl-2 protein family or its ability to bind to the principle adaptor proteins of apoptosis such as Apaf-1, FADD and TRADD. Bcl-2 protein is physiologically expressed in long-living cells. It is overexpressed with various intensity in malignant cells of hematopoietic origin and its presence is pathognomic for folicullar B-NHL lymphomas. Malignant clones with the overexpression of Bcl-2 are more aggressive and treatment resistant. Bcl-2 is thought to be involved in multiple drug resistance of cancer cells.
Bcl-2 protein and its role in the malignant transformation of cell
