Klin Onkol 2001; 14(4): 119-121.
Summary: Background: Neoplastic changes of the urinary tract lined by urothelium occur in multiple locations synchronously or metachronously. Multifocal occurrence of tumours in urthelium may influence the choice of treatment. The aim of the study is to find out occurrence and prognosis of transitional cell carcinoma of the prostate in the own clinical material. Design and subjects: In the retrospective study of 329 patients with superficial bladder tumours we were looking for patients with tumours localised in prostatic urethra. Prostatic involvement was defined as transitional cell carcinoma affecting mucosa of prostatic urethra and prostatic ducts. Methods and Results: Biopsy were obtained by transurethral resection from bladder tumours and patologically changed mucosa. Transitional cell carcinoma of the prostate was found in 9 of 329 (2.7 %) patients; in three of them synchronously with superficial bladder tumours and in six as the sole finding in prostatic urethra. Grade of differentiation of carcinoma cells: Grade 1: three time, Grade 2: four, and Grade 3: twice. Stage of invasion: Basement membrane of prostatic urethra was intact in five patients, four patients had an invasion of prostatic stroma. All patients with intact basement membrane, were treated by transurethral resection of tumour, four of them survived. All patients with infiltration of prostatic stroma regardless of the treatment option had died within one year. Conclusions: The presence of the transitional cell carcinoma in prostatic urethra influences the choice of treatment of patients with superficial bladder tumours. Infiltration of the prostatic stroma indicates bad prognosis.
