Klin Onkol 2000; 13(2): 48-51.
Summary: The spectrum of adult renal neoplasms arising from renal tubular epithelium includes papillary adenoma, oncocytoma, metanephric adenoma, conventional clear cell, papillary, chromophobe and collecting duct carcinoma. Sarcomatoid carcinoma is not viewed as a type per se, but rather represents a transformation noted in virtually all types of renal cell carcinoma. Application of common prognostic factors, such as TNM staging, nuclear grading system, histologic typing and their impact in prognostication is reviewed. Evidence exists that tumour stage is significantly associated with outcome. Numerous studies indicate an association of tumour grade based on nuclear characteristics with patient survival for renal cell carcinoma. Of biomolecular prognostic parameters, only assessment of tumour proliferation markers (Ki-67, PCNA) demonstrated good correlation with patients survival. The usefulness of additional prognostic information of other biomolecular factors like DNA content, tumor suppresor genes and neoangiogenesis remains uncertain.
