Klin Onkol 1999; 12(6): 196-199.
Abstract: The aim of the FASAY is to determine the effects of p53 mutations on the function and activity of the p53 protein. The method was successfully used for mutation analysis of p53 in various cell lines, somatic tumor cells and in blood cells for analysis of germ-line mutations. In addition, the method was also found effective in tests measuring affinity of mutant p53 proteins to promoters of target genes.
