Klin Onkol 1999; 12(5): 145-152.
Summary: The vast majority of non small-cell lung cancer cases is in an advanced stage of disease (III,IV) at the time of diagnosis. Prognosis of the disease has improved due to newly applied therapeutic regimens. These regimens include application of new antitumor drugs, eventually in combination with radiotherapy and lung resection. This is a review of the current therapy of advanced non small-cell lung cancer combined with surgery. Surgical procedure follows after induction (neoadjuvant) chemotherapy in the majority of cases. Accurate staging is not only the key point of the appropriate therapy, but also allows correct evaluation of therapeutic results. Confirmation of the superiority of the new therapeutic regimen by large randornized studies is still lacking. Invasive bioptic staging of advanced disease is currently irreplaceable. Clinical trials in the therapy of advanced lung cancer are necessary.
