Summary: The hematopoietic system in all its components is characterized by a multifrequency time structure with prominent rhythms in cell proliferation, cell function and appearance in the peripheral blood in different chronobiological frequencies. The.circulating elements in the peripheral blood show highly reproducible circadian rhythms. The timing and the extent of these rhythms were established in a clinically healthy human population. Not only the number blit also the reactivity of circulating blood cells varies predictably as a function of time. The circadian rhythm of cell proliferation in the hone marrow may allow timed treatment with cell cycle specific and nonspecific agents in an attempt to maximize the desired and to minimize tor) has also been shown in mice which, if confirmed, might reduce the cytotoxic effect of cytostatic drugs as well as improve the stimulation of peripheral stem cells for high dose chemotherapy regiments followed by transplantation of these cells. Chronotherapy by growth factors might lead to improvement of the situation in oncology - survival and quality of life.
Circadian rhythms of white blood cells and chronomodulatory effect of granulocyte colony stimulating factor (G-CSF)
