Klin Onkol 1998; 11(5): 144-146.
Abstract: The p53 protein exerts an antiproliferative effect, in response to various types of stress. p53 function is modulated in different ways, including mutations that occur frequently in tumours, as well as by several viral and cellular proteins. The MDM-2 oncoprotein is a potent inhibitor of p53. This protein binds the transcriptional activation domain of p53 and blocks its ability to regulate target genes that arc responsible for control of proliferation. The expression of the mdm2 gene itself is regulated by p53 in an autoregulatory feedback loop, which gives the opportunity to control p53 activity. Keeping p53 under control is most likely the major role of MDM-2. Tato práce byla podporovaná grantovými projekty IGA MZ ČR: 3477-3 a 4256-3
