Klin Onkol 1998; 11(3): 67-72.
Summary: Results in the treatment of advanced cervical carcinoma are still not satisfactory. Efforts for improvement lead to combining chemotherapy with standard surgical or radiation therapy. The most effective drug in the treatment of cervical carcinoma is cisplatin, and a combination with other cytostatics does not improve the effect. Many clinical studies tested chemotherapy in adjuvant, neoadjuvant and concomitant regimens. Adjuvant and neoadjuvant chemotherapy in addition to radical radiotherapy seems not to be effective. A more promissing treatment is chemotherapy before radical surgery in the bulky IB stage of disease and as concomitant chemoradiotherapy in more advanced stages of cervical carcinomas.
