Summary: In 93 multiple cyst fluid samples aspirated simultaneously or consequently in 33 women with gross cystic disease of the breast selected biochemical parameters (ions, metabolites, and tumor markers) were analyzed. It was found that 72 % of repeated cyst fluid samples withdrawn sequentionally in the same woman have the Na+ and K+ ratio of risky type (Na+/K+ is less or equal to 4,0, this ratio being considered as a measure of subsequent risk of carcinoma development). Recurrent filling of breast cysts was proved as the additional parameter of cancer risk; we found that there is a relation between the aspiration sequence and Na+/K+ ratio and also the level of tissue polypeptide antigen, lactate dehydrogenase, albumin, and glucose in cyst fluid. The data given can be used together with the conclusions of clinical examinations (mammography, sonography, cytology of cells from cyst fluid) for the determination of the probable high risk group of women with this disease.
The analysis of multiple cyst fluid samples in women with gross cystic disease of the breast
