Summary: The treatment of the hairy cell leukaemia (HCL) remains still a gross therapeutic problem. Even after introduction of the alpha-interferon and deoxycoformycin treatment in HCL a part of patients relapses. Several years lasting remissions were shown after treatment with deoxyadenosin (Cladribin) (2-CdA). We found in our seven patients with HCL after giving one course of 2-CdA in the dose 0.1mg per kg per day during 7 days complete normalisation of the blood cell count in five patients, a mild leucopenia remains in two patients 10 moths after treatment, in the patients with severe abdominal lymphadenopathy was seen a complete regression of the enlarged lymph nodes. No infectious complications were seen during the leucopenic period. Three months after finishing treatment we found normal haematopoesis without hairy cell presence in the control trepanobiopsy and a minimal infiltration in two patients, in two patients we not able to obtain the results till now, the seventh patient died one month after treatment course on myocardial infarction, so the control examination could not be done. We propose that in the HCL the 2-CdA treatment would become a first choice treatment in the patients without severe pancytopenia.
Experience with 2-chlorodeoxyadenosine i n 7 patients with hairy cell leukemia
