Klin Onkol 1992; 5(5): 141-146.
A total of 250 pts with germ cell testicular cancer were treated by PVB chemotherapy between 1982 to 1992. Mean age of patients was 28,9 years (range, 15-52). Thirty four pts in clinical stage I and II underwent primary RPLA with subsequent chemotherapy for pathological stage II (11pts - II.A, 13 pts - II.B, 10 pts - II.C). They were followed-up by mean of 106,3 months (range, 85-125). CR was achieved in 30 (88,2%) pts. Three pts have relapsed. Twenty seven (79,4%) pts are alive with no evidence of disease minimum 5 years since the onset of therapy. One hundred and twenty four pts underwent primary chemotherapy for clinical stage I.M (15pts), II.A (32pts), II.B (49pts) and II.C (28pts) with RPLA in cases with residual mass in the retroperitoneum. They were followed-up by mean of 47,7 months (range, 6-122). CR was achieved in 115 (92,7) pts (75 of them received chemotherapy alone, 40 pts achieved CR following combined cytostatic-surgical treatment). Eleven pts have relapsed. One hundred and eleven (89,5%) pts survive with no evidence of disease. Ninety four pts in stage III and IV (8 pts - III, 86 pts - IV) underwent primary chemotherapy with subsequent surgical removal of residual metastases. They were followed-up by mean of 50,5 months (range, 6-125). CR was achieved in 65 (69,1%) pts (32 of them received chemotherapy alone, 33 pts achieved CR following combined cytostatic-surgical treatment). Twelve pts have relapsed. Fifty seven (60,6%) pts survive with no evidence of disease.
There were 11 pts with advanced germ cell testicular cancer (stage II.C and IV) who underwent initial PVB chemotherapy without previous orchiectomy. Delayed orchiectomy was performed simultaneously with surgical removal of residual mass in the retroperitoneum or in the lungs or at complection of chemotherapy alone.
The toxicity of chemotherapy has been moderate. The pts (4,89%) died due to an acute complication of chemotherapy.
