Klin Onkol 1992; 5(4): 115-116.
Besides the stimulating factors, the cell growth is also influenced by factors with inhibitory activity. Their properties are for the time being less known and their activity more complex than the activity of the stimulating factors. In this paper the most known inhibitors are descreibed and a survey of cell sources of their production, target cells, chemical properties and their functions. Interesting is the heterogeneity of effects of the inhibitors, for example: growth suppresion of hematopoietic cells and induction of their differenciation, stimulation of lipoprotein lipase with subsequent losses of weight, bone resorption, induction of fibrosis etc.
In therapy it will be possible to use inhibitors suppressing the tumor cell growth presuming, that the normal cells will not be susceptible to inhibitors. On the contrary, when the tumor cells are not susceptible to inhibitors and the normal cells sensitive to them, it will be possible to use inhibitors in protection of the hematopoietic stem cells durting an aggressive cytotoxic therapy.
