In the review author has stressed the dosage as a critical factor in antineoplastic chemotherapy that therefore has to be managed radically and aggressivelly. He has referred to the significance of the term dose intensity and dose rate respectively (mg/m2/week and mg/m2/min.). Chemotherapy is then frequently accompanied by relevant acute and late toxicity. Author has pointed out on three possibilities of toxicity amelioration (mcnitoring of toxici-ty/synthesis of less toxic analogues/use of protective drugs and antidotes). He has analyzed mechanisms of organ-site toxicities in details (cardiotoxicity, nephrotoxicity, liver toxicity, lung toxicity, CŇS toxicity, vascular toxicity, bone marrow toxicity, nausea and vomiting). He has stressed the present-day tendency of an effort directed on increasing of therapeutic ratio by toxicity reduction.
Undesirable side effects of cytostatics and the prospect of their suppresion
