Dept. of Clinical Haematology, Prague; Institute of Haematology and Blood Transfusion, Prague, ČSFR
In the healthy organism in the growth regulation of haemopoietic cells exist in balance stimulatory and inhibitory factors. While the growth factors stimulating cell growth are already cloned and recently used in therapy, the spectrum of inhibitors is less complete and only in some of them we know the composition and genetic coding. The mechanism of activity of the inhibitors remains mostly within the working hypotheses. The situation is the more complicated because the inhibitory factors may work under certain conditions as stimulatory. The known inhibitors of cell growth are: lactoferrin, prostaglandines, acid-H-isoferritin, interferons, TGF beta, TNF, SCI (stemm cell inhibitor) and some other proteins. We are presenting our results of the inhibiting effect of acidic-H-isoferritin in vitro and in patients with myelodysplastic syndrome. In the future we are expecting a significant therapeutic effect of the inhibitors for example in the protection of the normal haemopoietic stemm cells during a cytotoxic treatment.
Growth inhibitors
