Klin Onkol 1991; 4(4): 114-116.
There are controversies in the treatment of inoperable non-small cell lung cancer because the effectivity of chemotherapy and radiotherapy is low and the patients do not reach long-term.survival. In 1985 Le Chevalier and Arriagada published surprisingly good results of treatment of inoperable nonmetastatic squamous cell lung cancer (Response rate 72%, complete response 55%). They used Cisplatin, Cyclophosphamid, Lomustine and Vindesine and radical radiotherapy to the total dose of 60 Gy. We modified this treatment protocol. We aplicated three courses of induction chemotherapy with Cisplatin, Cyclophosphamid, Lomustine and Vincristine. Radiotherapy were delivered in multifractionation regimen, daily two fractions of 1,5 Gy, 4 hours apart to the total dose of 51 Gy.
Treatmenfcompleted 51 patients. There were 18 patients with I and II stage and 33 patients with III stage. After treatment CR was 21,6%, PR 39,2% and RR 60,8%.
One to four years overall survival of 33 patients with III stage were: 73%, 40%, 26%, 10% respectively. The overall survival of the whole treatment group were significantly better than survival of control group of 65 patients treated by radiotherapy alone.
