Klin Onkol 1990; 3(6): 177-180.
Summary:
The authors have reported on preliminary results of hypoxiradiotherapy in the course of external irradiation in patients with uterine cervix cancer from a viewpoint of the occurrence of acute reactions and treatment complications. A mixture of nitrogen and oxygen containing 8,0 — 8,5 % of 02 was used to provoke acute hypoxia during irradiation. The applied dosis of external irradiation was simultaneously increased by 40 %. On the basis of a randomized study with 120 patients, acute hypoxia was found to protect healthy tissues against post-radiation damage. When the dosis of 96 Gy in the para-cervical space and that of 75 Gy in the pelvic wall were applied, acute side-effects decreased significantly if compared with a conventional radiotherapeutic procedure (p 0,01). Radiological preconditions for using acute hypoxia in radiotherapy are discussed.
