The purpose of review is the comparison of therapeutical strategies and results in chorioncarcinoma reported in literature with those of the Czechoslovakian Centre for Trophoblastic Disease (CCTD). Authors critically evaluate prognostic criteria, effectivity and toxicity of chemotherapeutic schedules reported in literature and discuss the obsolescence of some prognostic criteria still used. They underline the incomparability of the therapeutical results achieved in various centres when the comparison is based on the percentage of " all answers" and not on the ratio of patients with choriocarcinoma really definitely cured. The excessive toxicity of polychemotherapeutic schedules used in some centres is contrasted with the prognostic criteria, general therapeutic strategy and chemotherapeutic schedules of CCTD. In CCTD a very high therapeutics ratio has been achieved in 73 patients with choriocarcinoma, treated during the period 1975-1987, a high curability - 95% was reached with the hematological toxicity of 3-4 grade (according to the WHO scale) in 3 % of patients only. In spite of these very favorable results, further development of diagnostic and therapeutic strategies is needed as well as the research centered on the etiopathogenesy of the disease.
Chemotherapy of choriocarcinoma in relation to prognostic factors
