Summary: The aggressive non-Hodgkin´s lymphomas are characterized by the rapidly progressive clinical course with a trend to the widespread progression of disease. The change of the previously ominous prognosis was the consequence of radical combination chemotherapy, which is able to cure the significant proportion of patients with the diffuse large cell lymphomas, immunoblastic lymphomas, Burkitt´s lymphoma, lymphoblastic lymphomas, and probably also with nodular large cell lymphoma, and rarely also with other high and intermediate grade lymphomas. Radical chemotherapy is possible only if careful monitoring of patients and a good supportive therapy is available. The part of relapsed patients is possible to salvage with the combination of some newer cytostatic agents.
Chemotherapy of agressive non-hodgkin lymphoma
