In a group of 38 patients treated with Adriamycin and cisplatin, ECG-gated nuclear angiocardiography was proved to be a sufficiently snsitive method for the detection of myocardial function changes even in cases where they are not manifested clinically. It was assessed by evaluation of global functional parameters that both, significant heart dilatation and increase in heart beat frequency develop after the administration of both drugs and persist up to two years after the end of chemotherapy. On the other hand, no significant changes of the left ventricle ejection fraction were detected. Increase in stroke volume in combination with higher beat fequency compensate the dilated heart function so that the resulting cardiac output stays the same or is increasad and no clinical signes of myocardial functional changes occur in a healthy heart.
The sense of the radionuclid ventriculography by the value of the cardiotoxicity of the anticancer chemotherapy
