The advanced Hodgkin´s disease is the example of malignant neoplasm in which the aggressive effective chemotherapy considerably changed the prognosis of previously uncurable malignancy. Several combinations of cytostatic agents induce 70-90% of complete remission. The majority of complete responders do not relapse. Despite of the opinion of a great number of clinical oncologists that MOPP combination (nitrogen mustard, vincristine, procarbazin, and prednisone) is the satisfactory effective therapy, there in the accumulation of evidence that alternation of two or three non-cross resistant combinations is able to achieve even the better results. Radical chemotherapy necessitates the careful monitoring and treatment of toxicity. Radiotherapy administered on the areas with originally bulky lymph nodes diminish the relapse rate. Relapses are curable in a large proportion of patients with a salvage chemotherapy regiments and/or radiotherapy. It is necessary to look for the development of secondary malignancy during the follow-up period of several years after the treatment.
Chemotherapy of Hodgkin´s disease
